DDX24 — 130 ClinVar variants
All ClinVar germline DDX24 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
8 Likely benign · 122 Uncertain significance
Full DDX24 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 100
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX24 p.Ala127Val Uncertain significance Single submitter
- DDX24 p.Ala272Thr Uncertain significance Single submitter
- DDX24 p.Ala314Val Uncertain significance Single submitter
- DDX24 p.Ala329Ser Uncertain significance Single submitter
- DDX24 p.Ala378Thr Uncertain significance Single submitter
- DDX24 p.Ala419Val Uncertain significance Single submitter
- DDX24 p.Ala516Val Uncertain significance Single submitter
- DDX24 p.Arg201Met Uncertain significance Single submitter
- DDX24 p.Arg205Gln Uncertain significance Single submitter
- DDX24 p.Arg228His Uncertain significance Single submitter
- DDX24 p.Arg386Cys Uncertain significance Single submitter
- DDX24 p.Arg437Cys Uncertain significance Single submitter
- DDX24 p.Arg447Gln Uncertain significance Single submitter
- DDX24 p.Arg447Trp Uncertain significance Single submitter
- DDX24 p.Arg463Trp Uncertain significance Single submitter
- DDX24 p.Arg555Lys Uncertain significance Single submitter
- DDX24 p.Arg674Gln Uncertain significance Single submitter
- DDX24 p.Arg733Gln Uncertain significance Single submitter
- DDX24 p.Arg793Cys Uncertain significance Single submitter
- DDX24 p.Asn146Lys Uncertain significance Single submitter
- DDX24 p.Asn368Thr Uncertain significance Single submitter
- DDX24 p.Asn37Ser Uncertain significance Single submitter
- DDX24 p.Asn556Ser Uncertain significance Single submitter
- DDX24 p.Asp301Asn Uncertain significance Single submitter
- DDX24 p.Asp335Asn Uncertain significance Single submitter
- DDX24 p.Asp374Asn Uncertain significance Single submitter
- DDX24 p.Asp408Asn Uncertain significance Single submitter
- DDX24 p.Cys467Phe Uncertain significance Single submitter
- DDX24 p.Cys832Arg Uncertain significance Single submitter
- DDX24 p.Gln128Arg Uncertain significance Single submitter
- DDX24 p.Gln128Glu Uncertain significance Single submitter
- DDX24 p.Gln149His Uncertain significance Single submitter
- DDX24 p.Gln328His Uncertain significance Single submitter
- DDX24 p.Gln353Arg Uncertain significance Single submitter
- DDX24 p.Gln365His Uncertain significance Single submitter
- DDX24 p.Gln371Lys Uncertain significance Single submitter
- DDX24 p.Gln812His Uncertain significance Single submitter
- DDX24 p.Glu284Lys Uncertain significance Single submitter
- DDX24 p.Glu292Ala Uncertain significance Single submitter
- DDX24 p.Glu294Val Uncertain significance Single submitter
- DDX24 p.Glu52Val Uncertain significance Single submitter
- DDX24 p.Glu694Lys Uncertain significance Single submitter
- DDX24 p.Glu760Gly Uncertain significance Single submitter
- DDX24 p.Glu827Lys Uncertain significance Single submitter
- DDX24 p.Gly129Glu Uncertain significance Single submitter
- DDX24 p.Gly282Ala Uncertain significance Single submitter
- DDX24 p.Gly282Arg Uncertain significance Single submitter
- DDX24 p.Gly42Ala Uncertain significance Single submitter
- DDX24 p.Ile227Leu Uncertain significance Single submitter
- DDX24 p.Ile345Met Uncertain significance Single submitter
- DDX24 p.Ile345Val Uncertain significance Single submitter
- DDX24 p.Ile420Met Uncertain significance Single submitter
- DDX24 p.Ile420Val Uncertain significance Single submitter
- DDX24 p.Leu330Trp Uncertain significance Single submitter
- DDX24 p.Leu690Phe Uncertain significance Single submitter
- DDX24 p.Leu714Val Uncertain significance Single submitter
- DDX24 p.Leu796Val Uncertain significance Single submitter
- DDX24 p.Lys116Arg Uncertain significance Single submitter
- DDX24 p.Lys172Arg Uncertain significance Single submitter
- DDX24 p.Lys175Arg Uncertain significance Single submitter
- DDX24 p.Lys33Asn Uncertain significance Single submitter
- DDX24 p.Lys363Gln Uncertain significance Single submitter
- DDX24 p.Lys381Glu Uncertain significance Single submitter
- DDX24 p.Lys528Gln Uncertain significance Single submitter
- DDX24 p.Lys63Arg Uncertain significance Single submitter
- DDX24 p.Lys63Asn Uncertain significance Single submitter
- DDX24 p.Lys707Gln Uncertain significance Single submitter
- DDX24 p.Lys720Glu Uncertain significance Single submitter
- DDX24 p.Lys835Arg Uncertain significance Single submitter
- DDX24 p.Lys840Thr Uncertain significance Single submitter
- DDX24 p.Lys91Arg Uncertain significance Single submitter
- DDX24 p.Met132Val Uncertain significance Single submitter
- DDX24 p.Met142Ile Uncertain significance Single submitter
- DDX24 p.Met38Ile Uncertain significance Single submitter
- DDX24 p.Met491Thr Uncertain significance Single submitter
- DDX24 p.Met722Val Uncertain significance Single submitter
- DDX24 p.Phe18Leu Uncertain significance Single submitter
- DDX24 p.Phe332Cys Uncertain significance Single submitter
- DDX24 p.Pro182Leu Uncertain significance Single submitter
- DDX24 p.Pro202Ala Uncertain significance Single submitter
- DDX24 p.Pro816Ser Uncertain significance Single submitter
- DDX24 p.Ser166Phe Uncertain significance Single submitter
- DDX24 p.Ser855Asn Uncertain significance Single submitter
- DDX24 p.Ser92Cys Uncertain significance Single submitter
- DDX24 p.Ser92Phe Uncertain significance Single submitter
- DDX24 p.Thr150Pro Uncertain significance Single submitter
- DDX24 p.Thr179Arg Uncertain significance Single submitter
- DDX24 p.Thr222Ser Uncertain significance Single submitter
- DDX24 p.Thr270Ile Uncertain significance Single submitter
- DDX24 p.Thr321Ser Uncertain significance Single submitter
- DDX24 p.Thr366Ile Uncertain significance Single submitter
- DDX24 p.Thr427Met Uncertain significance Single submitter
- DDX24 p.Thr802Met Uncertain significance Single submitter
- DDX24 p.Thr811Ala Uncertain significance Single submitter
- DDX24 p.Tyr580Asn Uncertain significance Single submitter
- DDX24 p.Val199Ile Uncertain significance Single submitter
- DDX24 p.Val26Leu Uncertain significance Single submitter
- DDX24 p.Val469Ile Uncertain significance Single submitter
- DDX24 p.Val717Met Uncertain significance Single submitter
- DDX24 p.Val787Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- DDX24 p.Arg228Gly Uncertain significance Single submitter
- DDX24 p.Arg666Cys Uncertain significance Single submitter
- DDX24 p.Arg76Ile Uncertain significance Single submitter
- DDX24 p.Asp232Asn Uncertain significance Single submitter
- DDX24 p.Gln464Pro Uncertain significance Single submitter
- DDX24 p.Ile218Val Uncertain significance Single submitter
- DDX24 p.Leu465Phe Uncertain significance Single submitter
- DDX24 p.Lys100Gln Uncertain significance Single submitter
- DDX24 p.Pro202Leu Uncertain significance Single submitter
- DDX24 p.Pro517Ser Uncertain significance Single submitter
- DDX24 p.Ser213Phe Uncertain significance Single submitter
- DDX24 p.Thr222Ile Uncertain significance Single submitter
- DDX24 p.Thr705Lys Uncertain significance Single submitter
- DDX24 p.Val513Ala Uncertain significance Single submitter
- DDX24 p.Val513Glu Uncertain significance Single submitter
All DDX24 variants
Likely benign 8
- p.Arg602His Single submitter
- p.Asn683Ser Single submitter
- p.Glu357Lys Single submitter
- p.Ile313Thr Single submitter
- p.Leu125Pro Single submitter
- p.Met251Val Single submitter
- p.Ser826Gly Single submitter
- p.Tyr383His Single submitter
Uncertain significance 122
- p.Ala127Val Single submitter ⚠
- p.Ala272Thr Single submitter ⚠
- p.Ala314Val Single submitter ⚠
- p.Ala329Ser Single submitter ⚠
- p.Ala378Thr Single submitter ⚠
- p.Ala419Val Single submitter ⚠
- p.Ala516Val Single submitter ⚠
- p.Arg201Met Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg228Gly Single submitter ⚠
- p.Arg228His Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg437Cys Single submitter ⚠
- p.Arg447Gln Single submitter ⚠
- p.Arg447Trp Single submitter ⚠
- p.Arg463Trp Single submitter ⚠
- p.Arg555Lys Single submitter ⚠
- p.Arg589Cys Single submitter
- p.Arg666Cys Single submitter ⚠
- p.Arg674Gln Single submitter ⚠
- p.Arg733Gln Single submitter ⚠
- p.Arg76Ile Single submitter ⚠
- p.Arg793Cys Single submitter ⚠
- p.Asn146Lys Single submitter ⚠
- p.Asn368Thr Single submitter ⚠
- p.Asn37Ser Single submitter ⚠
- p.Asn556Ser Single submitter ⚠
- p.Asp232Asn Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp335Asn Single submitter ⚠
- p.Asp374Asn Single submitter ⚠
- p.Asp408Asn Single submitter ⚠
- p.Cys467Phe Single submitter ⚠
- p.Cys832Arg Single submitter ⚠
- p.Gln128Arg Single submitter ⚠
- p.Gln128Glu Single submitter ⚠
- p.Gln149His Single submitter ⚠
- p.Gln328His Single submitter ⚠
- p.Gln353Arg Single submitter ⚠
- p.Gln365His Single submitter ⚠
- p.Gln371Lys Single submitter ⚠
- p.Gln464Pro Single submitter ⚠
- p.Gln812His Single submitter ⚠
- p.Glu284Lys Single submitter ⚠
- p.Glu292Ala Single submitter ⚠
- p.Glu294Val Single submitter ⚠
- p.Glu52Val Single submitter ⚠
- p.Glu694Lys Single submitter ⚠
- p.Glu760Gly Single submitter ⚠
- p.Glu827Lys Single submitter ⚠
- p.Gly129Glu Single submitter ⚠
- p.Gly282Ala Single submitter ⚠
- p.Gly282Arg Single submitter ⚠
- p.Gly42Ala Single submitter ⚠
- p.Ile218Val Single submitter ⚠
- p.Ile227Leu Single submitter ⚠
- p.Ile252Phe Single submitter
- p.Ile345Met Single submitter ⚠
- p.Ile345Val Single submitter ⚠
- p.Ile420Met Single submitter ⚠
- p.Ile420Val Single submitter ⚠
- p.Leu330Trp Single submitter ⚠
- p.Leu465Phe Single submitter ⚠
- p.Leu485Phe Single submitter
- p.Leu610Val Single submitter
- p.Leu690Phe Single submitter ⚠
- p.Leu714Val Single submitter ⚠
- p.Leu796Val Single submitter ⚠
- p.Lys100Gln Single submitter ⚠
- p.Lys116Arg Single submitter ⚠
- p.Lys172Arg Single submitter ⚠
- p.Lys175Arg Single submitter ⚠
- p.Lys33Asn Single submitter ⚠
- p.Lys363Gln Single submitter ⚠
- p.Lys381Glu Single submitter ⚠
- p.Lys528Gln Single submitter ⚠
- p.Lys63Arg Single submitter ⚠
- p.Lys63Asn Single submitter ⚠
- p.Lys707Gln Single submitter ⚠
- p.Lys720Glu Single submitter ⚠
- p.Lys835Arg Single submitter ⚠
- p.Lys840Thr Single submitter ⚠
- p.Lys91Arg Single submitter ⚠
- p.Met132Val Single submitter ⚠
- p.Met142Ile Single submitter ⚠
- p.Met38Ile Single submitter ⚠
- p.Met491Thr Single submitter ⚠
- p.Met722Val Single submitter ⚠
- p.Phe18Leu Single submitter ⚠
- p.Phe332Cys Single submitter ⚠
- p.Pro182Leu Single submitter ⚠
- p.Pro202Ala Single submitter ⚠
- p.Pro202Leu Single submitter ⚠
- p.Pro517Ser Single submitter ⚠
- p.Pro816Ser Single submitter ⚠
- p.Ser166Phe Single submitter ⚠
- p.Ser213Phe Single submitter ⚠
- p.Ser675Thr Single submitter
- p.Ser855Asn Single submitter ⚠
- p.Ser92Cys Single submitter ⚠
- p.Ser92Phe Single submitter ⚠
- p.Thr150Pro Single submitter ⚠
- p.Thr179Arg Single submitter ⚠
- p.Thr222Ile Single submitter ⚠
- p.Thr222Ser Single submitter ⚠
- p.Thr270Ile Single submitter ⚠
- p.Thr321Ser Single submitter ⚠
- p.Thr366Ile Single submitter ⚠
- p.Thr418Ile Single submitter
- p.Thr427Met Single submitter ⚠
- p.Thr705Lys Single submitter ⚠
- p.Thr802Met Single submitter ⚠
- p.Thr811Ala Single submitter ⚠
- p.Trp258Arg Single submitter
- p.Tyr580Asn Single submitter ⚠
- p.Val199Ile Single submitter ⚠
- p.Val26Leu Single submitter ⚠
- p.Val469Ile Single submitter ⚠
- p.Val513Ala Single submitter ⚠
- p.Val513Glu Single submitter ⚠
- p.Val717Met Single submitter ⚠
- p.Val787Ile Single submitter ⚠