DDX42 — 98 ClinVar variants
All ClinVar germline DDX42 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
3 Likely benign · 95 Uncertain significance
Full DDX42 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX42 p.Ala344Gly Uncertain significance Single submitter
- DDX42 p.Ala41Ser Uncertain significance Single submitter
- DDX42 p.Ala67Val Uncertain significance Single submitter
- DDX42 p.Ala701Thr Uncertain significance Single submitter
- DDX42 p.Ala726Pro Uncertain significance Single submitter
- DDX42 p.Ala920Thr Uncertain significance Single submitter
- DDX42 p.Ala924Val Uncertain significance Single submitter
- DDX42 p.Arg242Gln Uncertain significance Single submitter
- DDX42 p.Arg429His Uncertain significance Single submitter
- DDX42 p.Arg491His Uncertain significance Single submitter
- DDX42 p.Arg814Gln Uncertain significance Single submitter
- DDX42 p.Arg814Trp Uncertain significance Single submitter
- DDX42 p.Arg818Pro Uncertain significance Single submitter
- DDX42 p.Arg892His Uncertain significance Single submitter
- DDX42 p.Asn219Ser Uncertain significance Single submitter
- DDX42 p.Asn226Ser Uncertain significance Single submitter
- DDX42 p.Asn240Ser Uncertain significance Single submitter
- DDX42 p.Asn510Ser Uncertain significance Single submitter
- DDX42 p.Asn608Ser Uncertain significance Single submitter
- DDX42 p.Asn675Ser Uncertain significance Single submitter
- DDX42 p.Asn750Thr Uncertain significance Single submitter
- DDX42 p.Asn771Ser Uncertain significance Single submitter
- DDX42 p.Asn788Ser Uncertain significance Single submitter
- DDX42 p.Asn804Ser Uncertain significance Single submitter
- DDX42 p.Asn826Ser Uncertain significance Single submitter
- DDX42 p.Asn85Ser Uncertain significance Single submitter
- DDX42 p.Asp125Asn Uncertain significance Single submitter
- DDX42 p.Asp82His Uncertain significance Single submitter
- DDX42 p.Asp830Asn Uncertain significance Single submitter
- DDX42 p.Asp87Ala Uncertain significance Single submitter
- DDX42 p.Glu223Lys Uncertain significance Single submitter
- DDX42 p.Glu888Ala Uncertain significance Single submitter
- DDX42 p.Gly47Val Uncertain significance Single submitter
- DDX42 p.Gly783Ala Uncertain significance Single submitter
- DDX42 p.Gly783Arg Uncertain significance Single submitter
- DDX42 p.Gly802Val Uncertain significance Single submitter
- DDX42 p.Gly805Arg Uncertain significance Single submitter
- DDX42 p.Gly837Ser Uncertain significance Single submitter
- DDX42 p.His479Gln Uncertain significance Single submitter
- DDX42 p.His749Arg Uncertain significance Single submitter
- DDX42 p.His819Gln Uncertain significance Single submitter
- DDX42 p.Ile772Met Uncertain significance Single submitter
- DDX42 p.Ile772Val Uncertain significance Single submitter
- DDX42 p.Leu31Phe Uncertain significance Single submitter
- DDX42 p.Leu492Met Uncertain significance Single submitter
- DDX42 p.Lys519Glu Uncertain significance Single submitter
- DDX42 p.Lys605Arg Uncertain significance Single submitter
- DDX42 p.Lys700Arg Uncertain significance Single submitter
- DDX42 p.Lys899Arg Uncertain significance Single submitter
- DDX42 p.Lys908Asn Uncertain significance Single submitter
- DDX42 p.Met633Leu Uncertain significance Single submitter
- DDX42 p.Pro310Ser Uncertain significance Single submitter
- DDX42 p.Pro53Leu Uncertain significance Single submitter
- DDX42 p.Ser22Asn Uncertain significance Single submitter
- DDX42 p.Ser253Ile Uncertain significance Single submitter
- DDX42 p.Ser709Thr Uncertain significance Single submitter
- DDX42 p.Ser736Thr Uncertain significance Single submitter
- DDX42 p.Ser773Thr Uncertain significance Single submitter
- DDX42 p.Ser83Cys Uncertain significance Single submitter
- DDX42 p.Ser850Gly Uncertain significance Single submitter
- DDX42 p.Thr169Ala Uncertain significance Single submitter
- DDX42 p.Thr396Ala Uncertain significance Single submitter
- DDX42 p.Thr434Ser Uncertain significance Single submitter
- DDX42 p.Thr569Ala Uncertain significance Single submitter
- DDX42 p.Thr697Met Uncertain significance Single submitter
- DDX42 p.Thr800Asn Uncertain significance Single submitter
- DDX42 p.Thr916Ile Uncertain significance Single submitter
- DDX42 p.Tyr210Ser Uncertain significance Single submitter
- DDX42 p.Val286Leu Uncertain significance Single submitter
- DDX42 p.Val740Ile Uncertain significance Single submitter
- DDX42 p.Val86Ile Uncertain significance Single submitter
- DDX42 p.Val86Phe Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- DDX42 p.Ala558Val Uncertain significance Single submitter
- DDX42 p.Ala702Val Uncertain significance Single submitter
- DDX42 p.Arg356Gln Uncertain significance Single submitter
- DDX42 p.Arg818Cys Uncertain significance Single submitter
- DDX42 p.Arg833His Uncertain significance Single submitter
- DDX42 p.Arg852His Uncertain significance Single submitter
- DDX42 p.Arg858Trp Uncertain significance Single submitter
- DDX42 p.Arg881Gln Uncertain significance Single submitter
- DDX42 p.Arg892Cys Uncertain significance Single submitter
- DDX42 p.Asn180Lys Uncertain significance Single submitter
- DDX42 p.Asn397Ser Uncertain significance Single submitter
- DDX42 p.Asn862Lys Uncertain significance Single submitter
- DDX42 p.Gly860Arg Uncertain significance Single submitter
- DDX42 p.His523Arg Uncertain significance Single submitter
- DDX42 p.Ile579Val Uncertain significance Single submitter
- DDX42 p.Lys298Arg Uncertain significance Single submitter
- DDX42 p.Lys650Met Uncertain significance Single submitter
- DDX42 p.Lys895Asn Uncertain significance Single submitter
- DDX42 p.Met265Thr Uncertain significance Single submitter
- DDX42 p.Met311Ile Uncertain significance Single submitter
- DDX42 p.Ser535Arg Uncertain significance Single submitter
All DDX42 variants
Likely benign 3
- p.Ala760Thr Single submitter
- p.Asn794Ser Single submitter
- p.His623= Single submitter
Uncertain significance 95
- p.Ala344Gly Single submitter ⚠
- p.Ala41Ser Single submitter ⚠
- p.Ala558Val Single submitter ⚠
- p.Ala67Val Single submitter ⚠
- p.Ala701Thr Single submitter ⚠
- p.Ala702Val Single submitter ⚠
- p.Ala726Pro Single submitter ⚠
- p.Ala920Thr Single submitter ⚠
- p.Ala924Val Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg356Gln Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg491His Single submitter ⚠
- p.Arg814Gln Single submitter ⚠
- p.Arg814Trp Single submitter ⚠
- p.Arg818Cys Single submitter ⚠
- p.Arg818Pro Single submitter ⚠
- p.Arg833His Single submitter ⚠
- p.Arg852His Single submitter ⚠
- p.Arg858Trp Single submitter ⚠
- p.Arg881Gln Single submitter ⚠
- p.Arg892Cys Single submitter ⚠
- p.Arg892His Single submitter ⚠
- p.Asn180Lys Single submitter ⚠
- p.Asn219Ser Single submitter ⚠
- p.Asn226Ser Single submitter ⚠
- p.Asn240Ser Single submitter ⚠
- p.Asn397Ser Single submitter ⚠
- p.Asn510Ser Single submitter ⚠
- p.Asn608Ser Single submitter ⚠
- p.Asn675Ser Single submitter ⚠
- p.Asn750Thr Single submitter ⚠
- p.Asn771Ser Single submitter ⚠
- p.Asn788Ser Single submitter ⚠
- p.Asn804Ser Single submitter ⚠
- p.Asn826Ser Single submitter ⚠
- p.Asn85Ser Single submitter ⚠
- p.Asn862Lys Single submitter ⚠
- p.Asp125Asn Single submitter ⚠
- p.Asp82His Single submitter ⚠
- p.Asp830Asn Single submitter ⚠
- p.Asp87Ala Single submitter ⚠
- p.Glu223Lys Single submitter ⚠
- p.Glu888Ala Single submitter ⚠
- p.Gly47Val Single submitter ⚠
- p.Gly783Ala Single submitter ⚠
- p.Gly783Arg Single submitter ⚠
- p.Gly802Val Single submitter ⚠
- p.Gly805Arg Single submitter ⚠
- p.Gly837Ser Single submitter ⚠
- p.Gly860Arg Single submitter ⚠
- p.His479Gln Single submitter ⚠
- p.His523Arg Single submitter ⚠
- p.His749Arg Single submitter ⚠
- p.His819Gln Single submitter ⚠
- p.Ile579Val Single submitter ⚠
- p.Ile772Met Single submitter ⚠
- p.Ile772Val Single submitter ⚠
- p.Leu31Phe Single submitter ⚠
- p.Leu492Met Single submitter ⚠
- p.Lys298Arg Single submitter ⚠
- p.Lys519Glu Single submitter ⚠
- p.Lys605Arg Single submitter ⚠
- p.Lys650Met Single submitter ⚠
- p.Lys700Arg Single submitter ⚠
- p.Lys895Asn Single submitter ⚠
- p.Lys899Arg Single submitter ⚠
- p.Lys908Asn Single submitter ⚠
- p.Met265fs Single submitter
- p.Met265Thr Single submitter ⚠
- p.Met311Ile Single submitter ⚠
- p.Met633Leu Single submitter ⚠
- p.Met633Val Single submitter
- p.Pro310Ser Single submitter ⚠
- p.Pro53Leu Single submitter ⚠
- p.Ser22Asn Single submitter ⚠
- p.Ser253Ile Single submitter ⚠
- p.Ser535Arg Single submitter ⚠
- p.Ser709Thr Single submitter ⚠
- p.Ser736Thr Single submitter ⚠
- p.Ser773Thr Single submitter ⚠
- p.Ser83Cys Single submitter ⚠
- p.Ser850Gly Single submitter ⚠
- p.Thr169Ala Single submitter ⚠
- p.Thr396Ala Single submitter ⚠
- p.Thr434Ser Single submitter ⚠
- p.Thr569Ala Single submitter ⚠
- p.Thr697Met Single submitter ⚠
- p.Thr800Asn Single submitter ⚠
- p.Thr916Ile Single submitter ⚠
- p.Tyr210Ser Single submitter ⚠
- p.Val286Leu Single submitter ⚠
- p.Val740Ile Single submitter ⚠
- p.Val86Ile Single submitter ⚠
- p.Val86Phe Single submitter ⚠