DDX52 — 79 ClinVar variants
All ClinVar germline DDX52 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
79 Uncertain significance
Full DDX52 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 55
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX52 p.Ala26Ser Uncertain significance Single submitter
- DDX52 p.Ala354Val Uncertain significance Single submitter
- DDX52 p.Ala534Ser Uncertain significance Single submitter
- DDX52 p.Arg19Lys Uncertain significance Single submitter
- DDX52 p.Arg203Trp Uncertain significance Single submitter
- DDX52 p.Arg295Gln Uncertain significance Single submitter
- DDX52 p.Arg446Lys Uncertain significance Single submitter
- DDX52 p.Arg83Ser Uncertain significance Single submitter
- DDX52 p.Asn370Ser Uncertain significance Single submitter
- DDX52 p.Asp326Gly Uncertain significance Single submitter
- DDX52 p.Asp440Tyr Uncertain significance Single submitter
- DDX52 p.Asp452Glu Uncertain significance Single submitter
- DDX52 p.Asp579Glu Uncertain significance Single submitter
- DDX52 p.Cys59Ser Uncertain significance Single submitter
- DDX52 p.Gln532His Uncertain significance Single submitter
- DDX52 p.Gln63Glu Uncertain significance Single submitter
- DDX52 p.Glu431Val Uncertain significance Single submitter
- DDX52 p.Gly130Arg Uncertain significance Single submitter
- DDX52 p.Gly184Asp Uncertain significance Single submitter
- DDX52 p.His150Tyr Uncertain significance Single submitter
- DDX52 p.His269Leu Uncertain significance Single submitter
- DDX52 p.His4Arg Uncertain significance Single submitter
- DDX52 p.Ile160Val Uncertain significance Single submitter
- DDX52 p.Ile221Ser Uncertain significance Single submitter
- DDX52 p.Ile288Thr Uncertain significance Single submitter
- DDX52 p.Ile442Thr Uncertain significance Single submitter
- DDX52 p.Ile467Met Uncertain significance Single submitter
- DDX52 p.Ile531Leu Uncertain significance Single submitter
- DDX52 p.Leu127Pro Uncertain significance Single submitter
- DDX52 p.Leu227Pro Uncertain significance Single submitter
- DDX52 p.Leu254Phe Uncertain significance Single submitter
- DDX52 p.Leu46Val Uncertain significance Single submitter
- DDX52 p.Leu549Val Uncertain significance Single submitter
- DDX52 p.Lys126Arg Uncertain significance Single submitter
- DDX52 p.Lys171Glu Uncertain significance Single submitter
- DDX52 p.Lys590Gln Uncertain significance Single submitter
- DDX52 p.Lys592Asn Uncertain significance Single submitter
- DDX52 p.Met93Ile Uncertain significance Single submitter
- DDX52 p.Pro293Thr Uncertain significance Single submitter
- DDX52 p.Pro56Leu Uncertain significance Single submitter
- DDX52 p.Ser241Pro Uncertain significance Single submitter
- DDX52 p.Ser344Phe Uncertain significance Single submitter
- DDX52 p.Thr128Ala Uncertain significance Single submitter
- DDX52 p.Thr162Ala Uncertain significance Single submitter
- DDX52 p.Thr261Ile Uncertain significance Single submitter
- DDX52 p.Thr343Ala Uncertain significance Single submitter
- DDX52 p.Thr397Ala Uncertain significance Single submitter
- DDX52 p.Thr569Ala Uncertain significance Single submitter
- DDX52 p.Thr94Ile Uncertain significance Single submitter
- DDX52 p.Trp464Cys Uncertain significance Single submitter
- DDX52 p.Val121Leu Uncertain significance Single submitter
- DDX52 p.Val312Ile Uncertain significance Single submitter
- DDX52 p.Val527Ile Uncertain significance Single submitter
- DDX52 p.Val530Ile Uncertain significance Single submitter
- DDX52 p.Val593Ile Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- DDX52 p.Ala247Thr Uncertain significance Single submitter
- DDX52 p.Ala336Pro Uncertain significance Single submitter
- DDX52 p.Arg136Thr Uncertain significance Single submitter
- DDX52 p.Arg144Gln Uncertain significance Single submitter
- DDX52 p.Arg332Gly Uncertain significance Single submitter
- DDX52 p.Asn294Lys Uncertain significance Single submitter
- DDX52 p.Asn529Tyr Uncertain significance Single submitter
- DDX52 p.Asp24Gly Uncertain significance Single submitter
- DDX52 p.Gly184Ala Uncertain significance Single submitter
- DDX52 p.Ile288Leu Uncertain significance Single submitter
- DDX52 p.Leu400Ile Uncertain significance Single submitter
- DDX52 p.Phe235Leu Uncertain significance Single submitter
- DDX52 p.Phe278Ser Uncertain significance Single submitter
- DDX52 p.Phe324Leu Uncertain significance Single submitter
- DDX52 p.Pro157Ala Uncertain significance Single submitter
- DDX52 p.Pro304Ser Uncertain significance Single submitter
All DDX52 variants
Uncertain significance 79
- p.Ala247Thr Single submitter ⚠
- p.Ala26Ser Single submitter ⚠
- p.Ala336Pro Single submitter ⚠
- p.Ala354Val Single submitter ⚠
- p.Ala534Ser Single submitter ⚠
- p.Arg136Thr Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg144Trp Single submitter
- p.Arg19Lys Single submitter ⚠
- p.Arg203Trp Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg332Gly Single submitter ⚠
- p.Arg446Lys Single submitter ⚠
- p.Arg83Ser Single submitter ⚠
- p.Asn294Lys Single submitter ⚠
- p.Asn370Ser Single submitter ⚠
- p.Asn529Tyr Single submitter ⚠
- p.Asp24Gly Single submitter ⚠
- p.Asp326Gly Single submitter ⚠
- p.Asp333His Single submitter
- p.Asp359Val Single submitter
- p.Asp440Tyr Single submitter ⚠
- p.Asp452Glu Single submitter ⚠
- p.Asp579Glu Single submitter ⚠
- p.Cys59Ser Single submitter ⚠
- p.Gln532His Single submitter ⚠
- p.Gln63Glu Single submitter ⚠
- p.Glu431Val Single submitter ⚠
- p.Gly130Arg Single submitter ⚠
- p.Gly184Ala Single submitter ⚠
- p.Gly184Asp Single submitter ⚠
- p.His150Tyr Single submitter ⚠
- p.His266Arg Single submitter
- p.His269Leu Single submitter ⚠
- p.His4Arg Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile221Ser Single submitter ⚠
- p.Ile288Leu Single submitter ⚠
- p.Ile288Thr Single submitter ⚠
- p.Ile433_Tyr434insTer Single submitter
- p.Ile442Thr Single submitter ⚠
- p.Ile467Met Single submitter ⚠
- p.Ile531Leu Single submitter ⚠
- p.Leu127Pro Single submitter ⚠
- p.Leu227Pro Single submitter ⚠
- p.Leu254Phe Single submitter ⚠
- p.Leu400Ile Single submitter ⚠
- p.Leu416Val Single submitter
- p.Leu428Ile Single submitter
- p.Leu46Val Single submitter ⚠
- p.Leu549Val Single submitter ⚠
- p.Lys126Arg Single submitter ⚠
- p.Lys171Glu Single submitter ⚠
- p.Lys590Gln Single submitter ⚠
- p.Lys592Asn Single submitter ⚠
- p.Met93Ile Single submitter ⚠
- p.Phe235Leu Single submitter ⚠
- p.Phe278Ser Single submitter ⚠
- p.Phe324Leu Single submitter ⚠
- p.Pro157Ala Single submitter ⚠
- p.Pro293Thr Single submitter ⚠
- p.Pro304Ser Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Ser241Pro Single submitter ⚠
- p.Ser344Phe Single submitter ⚠
- p.Thr128Ala Single submitter ⚠
- p.Thr162Ala Single submitter ⚠
- p.Thr189Met Single submitter
- p.Thr261Ile Single submitter ⚠
- p.Thr343Ala Single submitter ⚠
- p.Thr397Ala Single submitter ⚠
- p.Thr569Ala Single submitter ⚠
- p.Thr94Ile Single submitter ⚠
- p.Trp464Cys Single submitter ⚠
- p.Val121Leu Single submitter ⚠
- p.Val312Ile Single submitter ⚠
- p.Val527Ile Single submitter ⚠
- p.Val530Ile Single submitter ⚠
- p.Val593Ile Single submitter ⚠