DDX56 — 93 ClinVar variants
All ClinVar germline DDX56 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
3 Benign · 3 Likely benign · 87 Uncertain significance
Full DDX56 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DDX56 p.Arg84Lys Uncertain significance Multiple submitters
- DDX56 p.Ala116Val Uncertain significance Single submitter
- DDX56 p.Ala120Asp Uncertain significance Single submitter
- DDX56 p.Arg111Trp Uncertain significance Single submitter
- DDX56 p.Arg114Gly Uncertain significance Single submitter
- DDX56 p.Arg157His Uncertain significance Single submitter
- DDX56 p.Arg157Ser Uncertain significance Single submitter
- DDX56 p.Arg258Leu Uncertain significance Single submitter
- DDX56 p.Arg295His Uncertain significance Single submitter
- DDX56 p.Arg329Gln Uncertain significance Single submitter
- DDX56 p.Arg329Trp Uncertain significance Single submitter
- DDX56 p.Arg347Trp Uncertain significance Single submitter
- DDX56 p.Arg419Gln Uncertain significance Single submitter
- DDX56 p.Arg443Gln Uncertain significance Single submitter
- DDX56 p.Arg96Gly Uncertain significance Single submitter
- DDX56 p.Arg96Trp Uncertain significance Single submitter
- DDX56 p.Asn266Ser Uncertain significance Single submitter
- DDX56 p.Asn289Ser Uncertain significance Single submitter
- DDX56 p.Asn381Ser Uncertain significance Single submitter
- DDX56 p.Asn528Ser Uncertain significance Single submitter
- DDX56 p.Asp112Asn Uncertain significance Single submitter
- DDX56 p.Asp152Gly Uncertain significance Single submitter
- DDX56 p.Asp169Glu Uncertain significance Single submitter
- DDX56 p.Asp229Ala Uncertain significance Single submitter
- DDX56 p.Glu167Lys Uncertain significance Single submitter
- DDX56 p.Glu202Lys Uncertain significance Single submitter
- DDX56 p.Glu5Gln Uncertain significance Single submitter
- DDX56 p.Glu80Gln Uncertain significance Single submitter
- DDX56 p.Gly321Glu Uncertain significance Single submitter
- DDX56 p.Gly344Asp Uncertain significance Single submitter
- DDX56 p.Gly410Asp Uncertain significance Single submitter
- DDX56 p.Gly44Arg Uncertain significance Single submitter
- DDX56 p.Gly85Ser Uncertain significance Single submitter
- DDX56 p.His508Gln Uncertain significance Single submitter
- DDX56 p.His71Arg Uncertain significance Single submitter
- DDX56 p.Ile145Val Uncertain significance Single submitter
- DDX56 p.Ile33Phe Uncertain significance Single submitter
- DDX56 p.Ile370Val Uncertain significance Single submitter
- DDX56 p.Ile384Arg Uncertain significance Single submitter
- DDX56 p.Ile384Val Uncertain significance Single submitter
- DDX56 p.Leu218Pro Uncertain significance Single submitter
- DDX56 p.Leu248Met Uncertain significance Single submitter
- DDX56 p.Leu262Gln Uncertain significance Single submitter
- DDX56 p.Leu66Met Uncertain significance Single submitter
- DDX56 p.Leu66Val Uncertain significance Single submitter
- DDX56 p.Lys260Arg Uncertain significance Single submitter
- DDX56 p.Lys509Glu Uncertain significance Single submitter
- DDX56 p.Met101Thr Uncertain significance Single submitter
- DDX56 p.Met12Val Uncertain significance Single submitter
- DDX56 p.Phe277Ser Uncertain significance Single submitter
- DDX56 p.Phe351Val Uncertain significance Single submitter
- DDX56 p.Pro487Ser Uncertain significance Single submitter
- DDX56 p.Pro90Arg Uncertain significance Single submitter
- DDX56 p.Ser182Gly Uncertain significance Single submitter
- DDX56 p.Ser4Thr Uncertain significance Single submitter
- DDX56 p.Ser515Phe Uncertain significance Single submitter
- DDX56 p.Ser517Phe Uncertain significance Single submitter
- DDX56 p.Thr267Ser Uncertain significance Single submitter
- DDX56 p.Thr392Met Uncertain significance Single submitter
- DDX56 p.Val113Gly Uncertain significance Single submitter
- DDX56 p.Val265Gly Uncertain significance Single submitter
- DDX56 p.Val312Ile Uncertain significance Single submitter
- DDX56 p.Val354Met Uncertain significance Single submitter
- DDX56 p.Val505Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- DDX56 p.Ala60Val Uncertain significance Single submitter
- DDX56 p.Arg144His Uncertain significance Single submitter
- DDX56 p.Arg189Trp Uncertain significance Single submitter
- DDX56 p.Arg295Cys Uncertain significance Single submitter
- DDX56 p.Arg435Cys Uncertain significance Single submitter
- DDX56 p.Arg435His Uncertain significance Single submitter
- DDX56 p.Arg435Ser Uncertain significance Single submitter
- DDX56 p.Arg443Trp Uncertain significance Single submitter
- DDX56 p.Arg502Cys Uncertain significance Single submitter
- DDX56 p.Arg511Trp Uncertain significance Single submitter
- DDX56 p.Arg72Trp Uncertain significance Single submitter
- DDX56 p.Asn359Ser Uncertain significance Single submitter
- DDX56 p.Cys298Arg Uncertain significance Single submitter
- DDX56 p.Glu291Ala Uncertain significance Single submitter
- DDX56 p.Lys459Glu Uncertain significance Single submitter
- DDX56 p.Met434Ile Uncertain significance Single submitter
- DDX56 p.Phe304Leu Uncertain significance Single submitter
- DDX56 p.Tyr249Cys Benign Single submitter
- DDX56 p.Val89Leu Uncertain significance Single submitter
All DDX56 variants
Benign 3
- p.Gly85= Single submitter
- p.Leu413= Single submitter
- p.Tyr249Cys Single submitter ⚠
Likely benign 3
- p.Leu195= Single submitter
- p.Lys536Arg Single submitter
- p.Ser526= Single submitter
Uncertain significance 87
- p.Arg84Lys Multiple submitters ⚠
- p.Ala116Val Single submitter ⚠
- p.Ala120Asp Single submitter ⚠
- p.Ala445Val Single submitter
- p.Ala60Val Single submitter ⚠
- p.Arg111Trp Single submitter ⚠
- p.Arg114Gly Single submitter ⚠
- p.Arg144His Single submitter ⚠
- p.Arg157His Single submitter ⚠
- p.Arg157Ser Single submitter ⚠
- p.Arg189Trp Single submitter ⚠
- p.Arg258Leu Single submitter ⚠
- p.Arg295Cys Single submitter ⚠
- p.Arg295His Single submitter ⚠
- p.Arg329Gln Single submitter ⚠
- p.Arg329Trp Single submitter ⚠
- p.Arg347Trp Single submitter ⚠
- p.Arg419Gln Single submitter ⚠
- p.Arg435Cys Single submitter ⚠
- p.Arg435His Single submitter ⚠
- p.Arg435Ser Single submitter ⚠
- p.Arg443Gln Single submitter ⚠
- p.Arg443Trp Single submitter ⚠
- p.Arg475Trp Single submitter
- p.Arg502Cys Single submitter ⚠
- p.Arg511Trp Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Arg96Gly Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Asn266Ser Single submitter ⚠
- p.Asn289Ser Single submitter ⚠
- p.Asn359Ser Single submitter ⚠
- p.Asn381Ser Single submitter ⚠
- p.Asn528Ser Single submitter ⚠
- p.Asp112Asn Single submitter ⚠
- p.Asp152Gly Single submitter ⚠
- p.Asp169Glu Single submitter ⚠
- p.Asp229Ala Single submitter ⚠
- p.Cys298Arg Single submitter ⚠
- p.Cys430Gly Single submitter
- p.Glu167Lys Single submitter ⚠
- p.Glu202Lys Single submitter ⚠
- p.Glu291Ala Single submitter ⚠
- p.Glu5Gln Single submitter ⚠
- p.Glu80Gln Single submitter ⚠
- p.Gly13Cys Single submitter
- p.Gly321Glu Single submitter ⚠
- p.Gly344Asp Single submitter ⚠
- p.Gly410Asp Single submitter ⚠
- p.Gly44Arg Single submitter ⚠
- p.Gly85Ser Single submitter ⚠
- p.His353Pro Single submitter
- p.His508Gln Single submitter ⚠
- p.His71Arg Single submitter ⚠
- p.Ile145Val Single submitter ⚠
- p.Ile33Phe Single submitter ⚠
- p.Ile370Val Single submitter ⚠
- p.Ile384Arg Single submitter ⚠
- p.Ile384Val Single submitter ⚠
- p.Leu218Pro Single submitter ⚠
- p.Leu248Met Single submitter ⚠
- p.Leu262Gln Single submitter ⚠
- p.Leu66Met Single submitter ⚠
- p.Leu66Val Single submitter ⚠
- p.Lys260Arg Single submitter ⚠
- p.Lys459Glu Single submitter ⚠
- p.Lys509Glu Single submitter ⚠
- p.Met101Thr Single submitter ⚠
- p.Met12Val Single submitter ⚠
- p.Met434Ile Single submitter ⚠
- p.Phe277Ser Single submitter ⚠
- p.Phe304Leu Single submitter ⚠
- p.Phe351Val Single submitter ⚠
- p.Pro487Ser Single submitter ⚠
- p.Pro90Arg Single submitter ⚠
- p.Ser182Gly Single submitter ⚠
- p.Ser4Thr Single submitter ⚠
- p.Ser515Phe Single submitter ⚠
- p.Ser517Phe Single submitter ⚠
- p.Thr267Ser Single submitter ⚠
- p.Thr392Met Single submitter ⚠
- p.Val113Gly Single submitter ⚠
- p.Val265Gly Single submitter ⚠
- p.Val312Ile Single submitter ⚠
- p.Val354Met Single submitter ⚠
- p.Val505Leu Single submitter ⚠
- p.Val89Leu Single submitter ⚠