DECR2 — 72 ClinVar variants
All ClinVar germline DECR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
4 Likely benign · 68 Uncertain significance
Full DECR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DECR2 p.Ala124Thr Uncertain significance Single submitter
- DECR2 p.Ala129Thr Uncertain significance Single submitter
- DECR2 p.Ala16Val Uncertain significance Single submitter
- DECR2 p.Ala246Thr Uncertain significance Single submitter
- DECR2 p.Asn117Ser Uncertain significance Single submitter
- DECR2 p.Asn143Lys Uncertain significance Single submitter
- DECR2 p.Asp11Asn Uncertain significance Single submitter
- DECR2 p.Asp11Gly Uncertain significance Single submitter
- DECR2 p.Asp137Asn Uncertain significance Single submitter
- DECR2 p.Asp137Tyr Uncertain significance Single submitter
- DECR2 p.Asp86Asn Uncertain significance Single submitter
- DECR2 p.Gln172Glu Uncertain significance Single submitter
- DECR2 p.Glu9Lys Uncertain significance Single submitter
- DECR2 p.Gly10Ala Uncertain significance Single submitter
- DECR2 p.Gly158Glu Uncertain significance Single submitter
- DECR2 p.Gly168Ala Uncertain significance Single submitter
- DECR2 p.Gly171Arg Uncertain significance Single submitter
- DECR2 p.Gly171Val Uncertain significance Single submitter
- DECR2 p.Gly179Asp Uncertain significance Single submitter
- DECR2 p.Gly197Asp Uncertain significance Single submitter
- DECR2 p.Gly270Arg Uncertain significance Single submitter
- DECR2 p.Ile111Val Uncertain significance Single submitter
- DECR2 p.Leu148Arg Uncertain significance Single submitter
- DECR2 p.Leu167Pro Uncertain significance Single submitter
- DECR2 p.Leu250Phe Uncertain significance Single submitter
- DECR2 p.Leu72Pro Uncertain significance Single submitter
- DECR2 p.Lys230Asn Uncertain significance Single submitter
- DECR2 p.Met94Arg Uncertain significance Single submitter
- DECR2 p.Phe285Leu Uncertain significance Single submitter
- DECR2 p.Pro283Leu Uncertain significance Single submitter
- DECR2 p.Ser228Thr Uncertain significance Single submitter
- DECR2 p.Trp196Gly Uncertain significance Single submitter
- DECR2 p.Tyr251Cys Uncertain significance Single submitter
- DECR2 p.Val147Ala Uncertain significance Single submitter
- DECR2 p.Val8Gly Uncertain significance Single submitter
- DECR2 p.Val8Met Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- DECR2 p.Ala178Val Uncertain significance Single submitter
- DECR2 p.Ala187Val Uncertain significance Single submitter
- DECR2 p.Ala207Thr Uncertain significance Single submitter
- DECR2 p.Ala96Thr Uncertain significance Single submitter
- DECR2 p.Arg146His Uncertain significance Single submitter
- DECR2 p.Arg170Trp Uncertain significance Single submitter
- DECR2 p.Arg190Gln Uncertain significance Single submitter
- DECR2 p.Arg202His Uncertain significance Single submitter
- DECR2 p.Arg218Gln Uncertain significance Single submitter
- DECR2 p.Arg43Gln Uncertain significance Single submitter
- DECR2 p.Arg43Trp Uncertain significance Single submitter
- DECR2 p.Arg78Trp Uncertain significance Single submitter
- DECR2 p.Arg79Cys Uncertain significance Single submitter
- DECR2 p.Arg88Gln Uncertain significance Single submitter
- DECR2 p.Asp108Asn Uncertain significance Single submitter
- DECR2 p.Asp28Glu Uncertain significance Single submitter
- DECR2 p.Asp98Glu Uncertain significance Single submitter
- DECR2 p.Glu215Asp Uncertain significance Single submitter
- DECR2 p.Gly197Ser Uncertain significance Single submitter
- DECR2 p.Gly37Ser Uncertain significance Single submitter
- DECR2 p.Leu66Pro Uncertain significance Single submitter
- DECR2 p.Pro198Ser Uncertain significance Single submitter
- DECR2 p.Pro255Leu Uncertain significance Single submitter
- DECR2 p.Pro63Leu Uncertain significance Single submitter
- DECR2 p.Ser258Tyr Uncertain significance Single submitter
- DECR2 p.Thr55Met Uncertain significance Single submitter
- DECR2 p.Thr67Met Likely benign Single submitter
- DECR2 p.Tyr149Cys Uncertain significance Single submitter
- DECR2 p.Val144Met Uncertain significance Single submitter
- DECR2 p.Val161Met Uncertain significance Single submitter
- DECR2 p.Val203Ile Uncertain significance Single submitter
- DECR2 p.Val260Met Uncertain significance Single submitter
- DECR2 p.Val87Ile Uncertain significance Single submitter
All DECR2 variants
Likely benign 4
- p.Ala173Val Single submitter
- p.Arg106Lys Single submitter
- p.Phe285= Single submitter
- p.Thr67Met Single submitter ⚠
Uncertain significance 68
- p.Ala124Thr Single submitter ⚠
- p.Ala129Thr Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala178Val Single submitter ⚠
- p.Ala187Val Single submitter ⚠
- p.Ala207Thr Single submitter ⚠
- p.Ala246Thr Single submitter ⚠
- p.Ala96Thr Single submitter ⚠
- p.Arg146His Single submitter ⚠
- p.Arg170Trp Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg202His Single submitter ⚠
- p.Arg218Gln Single submitter ⚠
- p.Arg43Gln Single submitter ⚠
- p.Arg43Trp Single submitter ⚠
- p.Arg78Trp Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Arg88Gln Single submitter ⚠
- p.Asn117Ser Single submitter ⚠
- p.Asn143Lys Single submitter ⚠
- p.Asp108Asn Single submitter ⚠
- p.Asp11Asn Single submitter ⚠
- p.Asp11Gly Single submitter ⚠
- p.Asp137Asn Single submitter ⚠
- p.Asp137Tyr Single submitter ⚠
- p.Asp28Glu Single submitter ⚠
- p.Asp86Asn Single submitter ⚠
- p.Asp98Glu Single submitter ⚠
- p.Gln172Glu Single submitter ⚠
- p.Glu215Asp Single submitter ⚠
- p.Glu9Lys Single submitter ⚠
- p.Gly10Ala Single submitter ⚠
- p.Gly158Glu Single submitter ⚠
- p.Gly168Ala Single submitter ⚠
- p.Gly171Arg Single submitter ⚠
- p.Gly171Val Single submitter ⚠
- p.Gly179Asp Single submitter ⚠
- p.Gly197Asp Single submitter ⚠
- p.Gly197Ser Single submitter ⚠
- p.Gly270Arg Single submitter ⚠
- p.Gly37Ser Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Leu148Arg Single submitter ⚠
- p.Leu167Pro Single submitter ⚠
- p.Leu250Phe Single submitter ⚠
- p.Leu66Pro Single submitter ⚠
- p.Leu72Pro Single submitter ⚠
- p.Lys230Asn Single submitter ⚠
- p.Met94Arg Single submitter ⚠
- p.Phe285Leu Single submitter ⚠
- p.Pro198Ser Single submitter ⚠
- p.Pro255Leu Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Ser228Thr Single submitter ⚠
- p.Ser258Tyr Single submitter ⚠
- p.Thr55Met Single submitter ⚠
- p.Trp196Gly Single submitter ⚠
- p.Tyr149Cys Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Val144Met Single submitter ⚠
- p.Val147Ala Single submitter ⚠
- p.Val161Met Single submitter ⚠
- p.Val203Ile Single submitter ⚠
- p.Val260Met Single submitter ⚠
- p.Val87Ile Single submitter ⚠
- p.Val8Gly Single submitter ⚠
- p.Val8Met Single submitter ⚠