DEDD — 30 ClinVar variants
All ClinVar germline DEDD variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 29 Uncertain significance
Full DEDD gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEDD p.Arg124His Uncertain significance Single submitter
- DEDD p.Arg200Gln Uncertain significance Single submitter
- DEDD p.Arg28His Uncertain significance Single submitter
- DEDD p.Arg65His Uncertain significance Single submitter
- DEDD p.Arg83Gly Uncertain significance Single submitter
- DEDD p.Gln176Pro Uncertain significance Single submitter
- DEDD p.Gly174Arg Uncertain significance Single submitter
- DEDD p.Gly266Asp Uncertain significance Single submitter
- DEDD p.His39Tyr Uncertain significance Single submitter
- DEDD p.Leu113Val Uncertain significance Single submitter
- DEDD p.Met313Thr Uncertain significance Single submitter
- DEDD p.Pro138Ser Uncertain significance Single submitter
- DEDD p.Ser132Arg Uncertain significance Single submitter
- DEDD p.Ser25Thr Uncertain significance Single submitter
- DEDD p.Val101Ile Uncertain significance Single submitter
- DEDD p.Val275Ala Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DEDD p.Arg179Cys Uncertain significance Single submitter
- DEDD p.Arg196Lys Uncertain significance Single submitter
- DEDD p.Arg228Cys Uncertain significance Single submitter
- DEDD p.Arg58Cys Uncertain significance Single submitter
- DEDD p.Arg58His Uncertain significance Single submitter
- DEDD p.Arg7Trp Uncertain significance Single submitter
- DEDD p.Asp220Glu Uncertain significance Single submitter
- DEDD p.Glu189Lys Uncertain significance Single submitter
- DEDD p.His39Gln Uncertain significance Single submitter
- DEDD p.Ile277Val Uncertain significance Single submitter
- DEDD p.Leu4Ile Uncertain significance Single submitter
- DEDD p.Leu69Val Uncertain significance Single submitter
- DEDD p.Tyr125His Uncertain significance Single submitter
All DEDD variants
Likely benign 1
- p.Ala271= Single submitter
Uncertain significance 29
- p.Arg124His Single submitter ⚠
- p.Arg179Cys Single submitter ⚠
- p.Arg196Lys Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg228Cys Single submitter ⚠
- p.Arg28His Single submitter ⚠
- p.Arg58Cys Single submitter ⚠
- p.Arg58His Single submitter ⚠
- p.Arg65His Single submitter ⚠
- p.Arg7Trp Single submitter ⚠
- p.Arg83Gly Single submitter ⚠
- p.Asp220Glu Single submitter ⚠
- p.Gln176Pro Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Gly174Arg Single submitter ⚠
- p.Gly266Asp Single submitter ⚠
- p.His39Gln Single submitter ⚠
- p.His39Tyr Single submitter ⚠
- p.Ile277Val Single submitter ⚠
- p.Leu113Val Single submitter ⚠
- p.Leu4Ile Single submitter ⚠
- p.Leu69Val Single submitter ⚠
- p.Met313Thr Single submitter ⚠
- p.Pro138Ser Single submitter ⚠
- p.Ser132Arg Single submitter ⚠
- p.Ser25Thr Single submitter ⚠
- p.Tyr125His Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val275Ala Single submitter ⚠