DEDD2 — 59 ClinVar variants
All ClinVar germline DEDD2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
1 Benign · 1 Likely benign · 57 Uncertain significance
Full DEDD2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEDD2 p.Ala103Glu Uncertain significance Single submitter
- DEDD2 p.Ala52Val Uncertain significance Single submitter
- DEDD2 p.Arg201Trp Uncertain significance Single submitter
- DEDD2 p.Arg221Gln Uncertain significance Single submitter
- DEDD2 p.Arg28His Uncertain significance Single submitter
- DEDD2 p.Arg321Cys Uncertain significance Single submitter
- DEDD2 p.Gln180Arg Uncertain significance Single submitter
- DEDD2 p.Gly118Asp Uncertain significance Single submitter
- DEDD2 p.Gly65Ser Uncertain significance Single submitter
- DEDD2 p.Leu102Val Uncertain significance Single submitter
- DEDD2 p.Leu3Pro Uncertain significance Single submitter
- DEDD2 p.Leu42Gln Uncertain significance Single submitter
- DEDD2 p.Leu66Val Uncertain significance Single submitter
- DEDD2 p.Leu98Met Uncertain significance Single submitter
- DEDD2 p.Lys124Glu Uncertain significance Single submitter
- DEDD2 p.Phe30Tyr Uncertain significance Single submitter
- DEDD2 p.Pro153Ala Uncertain significance Single submitter
- DEDD2 p.Pro153Arg Uncertain significance Single submitter
- DEDD2 p.Pro322Leu Uncertain significance Single submitter
- DEDD2 p.Pro8Ser Uncertain significance Single submitter
- DEDD2 p.Thr154Ala Uncertain significance Single submitter
- DEDD2 p.Tyr117Cys Uncertain significance Single submitter
- DEDD2 p.Val231Leu Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- DEDD2 p.Ala177Val Uncertain significance Single submitter
- DEDD2 p.Arg114Cys Uncertain significance Single submitter
- DEDD2 p.Arg131Cys Uncertain significance Single submitter
- DEDD2 p.Arg132Cys Uncertain significance Single submitter
- DEDD2 p.Arg132His Uncertain significance Single submitter
- DEDD2 p.Arg156Gln Uncertain significance Single submitter
- DEDD2 p.Arg159Trp Uncertain significance Single submitter
- DEDD2 p.Arg161Trp Uncertain significance Single submitter
- DEDD2 p.Arg171Gln Uncertain significance Single submitter
- DEDD2 p.Arg171Trp Uncertain significance Single submitter
- DEDD2 p.Arg172Gln Uncertain significance Single submitter
- DEDD2 p.Arg172Trp Uncertain significance Single submitter
- DEDD2 p.Arg201Gln Uncertain significance Single submitter
- DEDD2 p.Arg220Trp Uncertain significance Single submitter
- DEDD2 p.Arg227Gln Uncertain significance Single submitter
- DEDD2 p.Arg290Trp Uncertain significance Single submitter
- DEDD2 p.Arg309His Uncertain significance Single submitter
- DEDD2 p.Arg320Trp Uncertain significance Single submitter
- DEDD2 p.Arg321His Uncertain significance Single submitter
- DEDD2 p.Arg91Gly Uncertain significance Single submitter
- DEDD2 p.Gln88His Uncertain significance Single submitter
- DEDD2 p.Glu255Asp Uncertain significance Single submitter
- DEDD2 p.Glu316Val Uncertain significance Single submitter
- DEDD2 p.Glu67Ala Uncertain significance Single submitter
- DEDD2 p.Gly318Arg Uncertain significance Single submitter
- DEDD2 p.Gly318Val Uncertain significance Single submitter
- DEDD2 p.Leu18Gln Uncertain significance Single submitter
- DEDD2 p.Pro153Leu Uncertain significance Single submitter
- DEDD2 p.Pro153Thr Uncertain significance Single submitter
- DEDD2 p.Pro188Thr Uncertain significance Single submitter
- DEDD2 p.Ser121Ile Uncertain significance Single submitter
- DEDD2 p.Ser137Arg Uncertain significance Single submitter
- DEDD2 p.Ser64Asn Uncertain significance Single submitter
- DEDD2 p.Val278Met Uncertain significance Single submitter
All DEDD2 variants
Benign 1
- p.Cys207= Single submitter
Likely benign 1
- p.Gly277= Single submitter
Uncertain significance 57
- p.Ala103Glu Single submitter ⚠
- p.Ala177Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg132Cys Single submitter ⚠
- p.Arg132His Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg159Trp Single submitter ⚠
- p.Arg161Trp Single submitter ⚠
- p.Arg171Gln Single submitter ⚠
- p.Arg171Trp Single submitter ⚠
- p.Arg172Gln Single submitter ⚠
- p.Arg172Trp Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg201Trp Single submitter ⚠
- p.Arg220Trp Single submitter ⚠
- p.Arg221Gln Single submitter ⚠
- p.Arg227Gln Single submitter ⚠
- p.Arg28His Single submitter ⚠
- p.Arg290Trp Single submitter ⚠
- p.Arg309His Single submitter ⚠
- p.Arg320Trp Single submitter ⚠
- p.Arg321Cys Single submitter ⚠
- p.Arg321His Single submitter ⚠
- p.Arg91Gly Single submitter ⚠
- p.Gln180Arg Single submitter ⚠
- p.Gln88His Single submitter ⚠
- p.Glu255Asp Single submitter ⚠
- p.Glu316Val Single submitter ⚠
- p.Glu67Ala Single submitter ⚠
- p.Gly118Asp Single submitter ⚠
- p.Gly318Arg Single submitter ⚠
- p.Gly318Val Single submitter ⚠
- p.Gly65Ser Single submitter ⚠
- p.Leu102Val Single submitter ⚠
- p.Leu18Gln Single submitter ⚠
- p.Leu3Pro Single submitter ⚠
- p.Leu42Gln Single submitter ⚠
- p.Leu66Val Single submitter ⚠
- p.Leu98Met Single submitter ⚠
- p.Lys124Glu Single submitter ⚠
- p.Phe30Tyr Single submitter ⚠
- p.Pro153Ala Single submitter ⚠
- p.Pro153Arg Single submitter ⚠
- p.Pro153Leu Single submitter ⚠
- p.Pro153Thr Single submitter ⚠
- p.Pro188Thr Single submitter ⚠
- p.Pro322Leu Single submitter ⚠
- p.Pro8Ser Single submitter ⚠
- p.Ser121Ile Single submitter ⚠
- p.Ser137Arg Single submitter ⚠
- p.Ser64Asn Single submitter ⚠
- p.Thr154Ala Single submitter ⚠
- p.Tyr117Cys Single submitter ⚠
- p.Val231Leu Single submitter ⚠
- p.Val278Met Single submitter ⚠