DEFB131B — 2 ClinVar variants
All ClinVar germline DEFB131B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
2 Uncertain significance
Full DEFB131B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All DEFB131B variants
Uncertain significance 2
- p.Trp70Arg Single submitter ⚠
- p.Val3Ala Single submitter ⚠