DEK — 49 ClinVar variants
All ClinVar germline DEK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Likely benign · 46 Uncertain significance
Full DEK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEK p.Ala18Gly Uncertain significance Single submitter
- DEK p.Ala214Val Uncertain significance Single submitter
- DEK p.Ala334Asp Uncertain significance Single submitter
- DEK p.Ala3Val Uncertain significance Single submitter
- DEK p.Ala7Thr Uncertain significance Single submitter
- DEK p.Ala81Glu Uncertain significance Single submitter
- DEK p.Arg208Gln Uncertain significance Single submitter
- DEK p.Arg29Gly Uncertain significance Single submitter
- DEK p.Asn281Asp Uncertain significance Single submitter
- DEK p.Asn281Ser Uncertain significance Single submitter
- DEK p.Asp39Asn Uncertain significance Single submitter
- DEK p.Gln267Pro Uncertain significance Single submitter
- DEK p.Gln345Glu Uncertain significance Single submitter
- DEK p.Glu11Gly Uncertain significance Single submitter
- DEK p.Glu136Asp Uncertain significance Single submitter
- DEK p.Glu236Gly Uncertain significance Single submitter
- DEK p.Glu34Lys Uncertain significance Single submitter
- DEK p.Gly27Ser Uncertain significance Single submitter
- DEK p.Gly85Glu Uncertain significance Single submitter
- DEK p.Ile160Val Uncertain significance Single submitter
- DEK p.Ile374Val Uncertain significance Single submitter
- DEK p.Ile94Val Uncertain significance Single submitter
- DEK p.Lys257Glu Uncertain significance Single submitter
- DEK p.Lys291Arg Uncertain significance Single submitter
- DEK p.Lys299Thr Uncertain significance Single submitter
- DEK p.Lys48Glu Uncertain significance Single submitter
- DEK p.Lys57Arg Uncertain significance Single submitter
- DEK p.Met156Ile Uncertain significance Single submitter
- DEK p.Met156Thr Uncertain significance Single submitter
- DEK p.Met68Val Uncertain significance Single submitter
- DEK p.Pro223Ala Uncertain significance Single submitter
- DEK p.Pro319His Uncertain significance Single submitter
- DEK p.Pro6Leu Uncertain significance Single submitter
- DEK p.Thr290Asn Uncertain significance Single submitter
- DEK p.Thr328Lys Uncertain significance Single submitter
- DEK p.Thr356Ile Uncertain significance Single submitter
- DEK p.Val370Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- DEK p.Glu41Ala Uncertain significance Single submitter
- DEK p.Glu41Gln Uncertain significance Single submitter
- DEK p.Lys101Gln Uncertain significance Single submitter
- DEK p.Pro194Leu Uncertain significance Single submitter
- DEK p.Ser271Phe Uncertain significance Single submitter
- DEK p.Ser279Arg Uncertain significance Single submitter
- DEK p.Ser307Leu Uncertain significance Single submitter
- DEK p.Val176Leu Uncertain significance Single submitter
- DEK p.Val54Met Uncertain significance Single submitter
All DEK variants
Likely benign 3
- p.Asp39Glu Single submitter
- p.Asp40Glu Single submitter
- p.Lys151= Single submitter
Uncertain significance 46
- p.Ala18Gly Single submitter ⚠
- p.Ala214Val Single submitter ⚠
- p.Ala334Asp Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Ala7Thr Single submitter ⚠
- p.Ala81Glu Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Asn281Asp Single submitter ⚠
- p.Asn281Ser Single submitter ⚠
- p.Asp39Asn Single submitter ⚠
- p.Gln267Pro Single submitter ⚠
- p.Gln345Glu Single submitter ⚠
- p.Glu11Gly Single submitter ⚠
- p.Glu136Asp Single submitter ⚠
- p.Glu236Gly Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu41Ala Single submitter ⚠
- p.Glu41Gln Single submitter ⚠
- p.Gly27Ser Single submitter ⚠
- p.Gly85Glu Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile374Val Single submitter ⚠
- p.Ile94Val Single submitter ⚠
- p.Lys101Gln Single submitter ⚠
- p.Lys257Glu Single submitter ⚠
- p.Lys291Arg Single submitter ⚠
- p.Lys299Thr Single submitter ⚠
- p.Lys48Glu Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Met156Ile Single submitter ⚠
- p.Met156Thr Single submitter ⚠
- p.Met68Val Single submitter ⚠
- p.Pro194Leu Single submitter ⚠
- p.Pro223Ala Single submitter ⚠
- p.Pro319His Single submitter ⚠
- p.Pro6Leu Single submitter ⚠
- p.Ser271Phe Single submitter ⚠
- p.Ser279Arg Single submitter ⚠
- p.Ser307Leu Single submitter ⚠
- p.Thr290Asn Single submitter ⚠
- p.Thr328Lys Single submitter ⚠
- p.Thr356Ile Single submitter ⚠
- p.Val176Leu Single submitter ⚠
- p.Val370Ile Single submitter ⚠
- p.Val54Met Single submitter ⚠