DENND10 — 43 ClinVar variants
All ClinVar germline DENND10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Likely benign · 41 Uncertain significance
Full DENND10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND10 p.Ala221Thr Uncertain significance Single submitter
- DENND10 p.Ala2Asp Uncertain significance Single submitter
- DENND10 p.Ala3Ser Uncertain significance Single submitter
- DENND10 p.Ala3Val Uncertain significance Single submitter
- DENND10 p.Arg151Gln Uncertain significance Single submitter
- DENND10 p.Arg325Gly Uncertain significance Single submitter
- DENND10 p.Asn254Ser Uncertain significance Single submitter
- DENND10 p.Asp250Glu Uncertain significance Single submitter
- DENND10 p.Gln299Arg Uncertain significance Single submitter
- DENND10 p.Gly16Ala Uncertain significance Single submitter
- DENND10 p.Gly322Ala Uncertain significance Single submitter
- DENND10 p.His174Tyr Uncertain significance Single submitter
- DENND10 p.His218Tyr Uncertain significance Single submitter
- DENND10 p.His296Tyr Uncertain significance Single submitter
- DENND10 p.Ile183Thr Uncertain significance Single submitter
- DENND10 p.Ile262Thr Uncertain significance Single submitter
- DENND10 p.Leu203Pro Uncertain significance Single submitter
- DENND10 p.Leu275Val Uncertain significance Single submitter
- DENND10 p.Leu329Ser Uncertain significance Single submitter
- DENND10 p.Lys160Arg Uncertain significance Single submitter
- DENND10 p.Lys83Gln Uncertain significance Single submitter
- DENND10 p.Lys95Arg Uncertain significance Single submitter
- DENND10 p.Met112Thr Uncertain significance Single submitter
- DENND10 p.Met178Thr Uncertain significance Single submitter
- DENND10 p.Met279Val Uncertain significance Single submitter
- DENND10 p.Pro339Arg Uncertain significance Single submitter
- DENND10 p.Ser158Phe Uncertain significance Single submitter
- DENND10 p.Ser295Asn Uncertain significance Single submitter
- DENND10 p.Thr197Ile Uncertain significance Single submitter
- DENND10 p.Thr35Met Uncertain significance Single submitter
- DENND10 p.Thr72Ser Uncertain significance Single submitter
- DENND10 p.Tyr113Phe Uncertain significance Single submitter
- DENND10 p.Val15Ala Uncertain significance Single submitter
- DENND10 p.Val297Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- DENND10 p.Glu100Lys Uncertain significance Single submitter
- DENND10 p.Ile127Thr Uncertain significance Single submitter
- DENND10 p.Phe252Leu Uncertain significance Single submitter
- DENND10 p.Thr106Ile Uncertain significance Single submitter
- DENND10 p.Thr211Ile Uncertain significance Single submitter
- DENND10 p.Val185Met Uncertain significance Single submitter
All DENND10 variants
Likely benign 2
- p.Ala94Thr Single submitter
- p.Ile74Val Single submitter
Uncertain significance 41
- p.Ala221Thr Single submitter ⚠
- p.Ala2Asp Single submitter ⚠
- p.Ala3Ser Single submitter ⚠
- p.Ala3Val Single submitter ⚠
- p.Arg151Gln Single submitter ⚠
- p.Arg325Gly Single submitter ⚠
- p.Asn254Ser Single submitter ⚠
- p.Asp250Glu Single submitter ⚠
- p.Gln299Arg Single submitter ⚠
- p.Glu100Lys Single submitter ⚠
- p.Gly167Glu Single submitter
- p.Gly16Ala Single submitter ⚠
- p.Gly322Ala Single submitter ⚠
- p.His174Tyr Single submitter ⚠
- p.His218Tyr Single submitter ⚠
- p.His296Tyr Single submitter ⚠
- p.Ile127Thr Single submitter ⚠
- p.Ile183Thr Single submitter ⚠
- p.Ile262Thr Single submitter ⚠
- p.Leu203Pro Single submitter ⚠
- p.Leu275Val Single submitter ⚠
- p.Leu329Ser Single submitter ⚠
- p.Lys160Arg Single submitter ⚠
- p.Lys83Gln Single submitter ⚠
- p.Lys95Arg Single submitter ⚠
- p.Met112Thr Single submitter ⚠
- p.Met178Thr Single submitter ⚠
- p.Met279Val Single submitter ⚠
- p.Phe252Leu Single submitter ⚠
- p.Pro339Arg Single submitter ⚠
- p.Ser158Phe Single submitter ⚠
- p.Ser295Asn Single submitter ⚠
- p.Thr106Ile Single submitter ⚠
- p.Thr197Ile Single submitter ⚠
- p.Thr211Ile Single submitter ⚠
- p.Thr35Met Single submitter ⚠
- p.Thr72Ser Single submitter ⚠
- p.Tyr113Phe Single submitter ⚠
- p.Val15Ala Single submitter ⚠
- p.Val185Met Single submitter ⚠
- p.Val297Ile Single submitter ⚠