DENND11 — 79 ClinVar variants
All ClinVar germline DENND11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
79 Uncertain significance
Full DENND11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND11 p.Ala149Thr Uncertain significance Multiple submitters
- DENND11 p.Asp345Asn Uncertain significance Multiple submitters
- DENND11 p.Ala29Val Uncertain significance Single submitter
- DENND11 p.Ala317Val Uncertain significance Single submitter
- DENND11 p.Ala409Thr Uncertain significance Single submitter
- DENND11 p.Ala43Pro Uncertain significance Single submitter
- DENND11 p.Arg126Gln Uncertain significance Single submitter
- DENND11 p.Arg150Trp Uncertain significance Single submitter
- DENND11 p.Arg220Gln Uncertain significance Single submitter
- DENND11 p.Arg328Gln Uncertain significance Single submitter
- DENND11 p.Arg399Gln Uncertain significance Single submitter
- DENND11 p.Arg431Gln Uncertain significance Single submitter
- DENND11 p.Arg50Leu Uncertain significance Single submitter
- DENND11 p.Arg66Leu Uncertain significance Single submitter
- DENND11 p.Asn365Ser Uncertain significance Single submitter
- DENND11 p.Asn382Ser Uncertain significance Single submitter
- DENND11 p.Gln23His Uncertain significance Single submitter
- DENND11 p.Gln4His Uncertain significance Single submitter
- DENND11 p.Gln63His Uncertain significance Single submitter
- DENND11 p.Glu307Lys Uncertain significance Single submitter
- DENND11 p.Glu329Lys Uncertain significance Single submitter
- DENND11 p.Glu378Lys Uncertain significance Single submitter
- DENND11 p.Gly132Cys Uncertain significance Single submitter
- DENND11 p.Gly204Ser Uncertain significance Single submitter
- DENND11 p.Gly287Asp Uncertain significance Single submitter
- DENND11 p.Gly290Cys Uncertain significance Single submitter
- DENND11 p.Gly290Val Uncertain significance Single submitter
- DENND11 p.Gly30Arg Uncertain significance Single submitter
- DENND11 p.Gly30Glu Uncertain significance Single submitter
- DENND11 p.Gly422Asp Uncertain significance Single submitter
- DENND11 p.His187Asp Uncertain significance Single submitter
- DENND11 p.His343Pro Uncertain significance Single submitter
- DENND11 p.Ile306Val Uncertain significance Single submitter
- DENND11 p.Lys296Arg Uncertain significance Single submitter
- DENND11 p.Met151Ile Uncertain significance Single submitter
- DENND11 p.Met446Thr Uncertain significance Single submitter
- DENND11 p.Pro159Ala Uncertain significance Single submitter
- DENND11 p.Pro210Thr Uncertain significance Single submitter
- DENND11 p.Pro216Ser Uncertain significance Single submitter
- DENND11 p.Pro22Leu Uncertain significance Single submitter
- DENND11 p.Pro58Arg Uncertain significance Single submitter
- DENND11 p.Tyr315Cys Uncertain significance Single submitter
- DENND11 p.Tyr334Cys Uncertain significance Single submitter
- DENND11 p.Val283Ile Uncertain significance Single submitter
- DENND11 p.Val333Ile Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- DENND11 p.Ala14Val Uncertain significance Single submitter
- DENND11 p.Ala253Val Uncertain significance Single submitter
- DENND11 p.Ala29Thr Uncertain significance Single submitter
- DENND11 p.Ala7Val Uncertain significance Single submitter
- DENND11 p.Arg12His Uncertain significance Single submitter
- DENND11 p.Arg34Gln Uncertain significance Single submitter
- DENND11 p.Arg362His Uncertain significance Single submitter
- DENND11 p.Arg363Trp Uncertain significance Single submitter
- DENND11 p.Arg421Gln Uncertain significance Single submitter
- DENND11 p.Arg421Trp Uncertain significance Single submitter
- DENND11 p.Arg431Trp Uncertain significance Single submitter
- DENND11 p.Asp102Glu Uncertain significance Single submitter
- DENND11 p.Asp305Asn Uncertain significance Single submitter
- DENND11 p.Asp86Tyr Uncertain significance Single submitter
- DENND11 p.Cys96Tyr Uncertain significance Single submitter
- DENND11 p.Gly233Ser Uncertain significance Single submitter
- DENND11 p.Gly33Asp Uncertain significance Single submitter
- DENND11 p.Gly429Glu Uncertain significance Single submitter
- DENND11 p.Ile400Val Uncertain significance Single submitter
- DENND11 p.Leu372Phe Uncertain significance Single submitter
- DENND11 p.Lys296Glu Uncertain significance Single submitter
- DENND11 p.Met423Leu Uncertain significance Single submitter
- DENND11 p.Phe242Leu Uncertain significance Single submitter
- DENND11 p.Phe252Cys Uncertain significance Single submitter
- DENND11 p.Phe389Leu Uncertain significance Single submitter
- DENND11 p.Pro264Ser Uncertain significance Single submitter
- DENND11 p.Pro42Leu Uncertain significance Single submitter
- DENND11 p.Pro47Leu Uncertain significance Single submitter
- DENND11 p.Tyr441Cys Uncertain significance Single submitter
- DENND11 p.Val19Phe Uncertain significance Single submitter
- DENND11 p.Val274Ala Uncertain significance Single submitter
- DENND11 p.Val301Met Uncertain significance Single submitter
- DENND11 p.Val340Met Uncertain significance Single submitter
- DENND11 p.Val390Met Uncertain significance Single submitter
All DENND11 variants
Uncertain significance 79
- p.Ala149Thr Multiple submitters ⚠
- p.Asp345Asn Multiple submitters ⚠
- p.Ala14Val Single submitter ⚠
- p.Ala253Val Single submitter ⚠
- p.Ala29Thr Single submitter ⚠
- p.Ala29Val Single submitter ⚠
- p.Ala317Val Single submitter ⚠
- p.Ala409Thr Single submitter ⚠
- p.Ala43Pro Single submitter ⚠
- p.Ala7Val Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg12His Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg220Gln Single submitter ⚠
- p.Arg328Gln Single submitter ⚠
- p.Arg34Gln Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg363Trp Single submitter ⚠
- p.Arg399Gln Single submitter ⚠
- p.Arg421Gln Single submitter ⚠
- p.Arg421Trp Single submitter ⚠
- p.Arg431Gln Single submitter ⚠
- p.Arg431Trp Single submitter ⚠
- p.Arg50Leu Single submitter ⚠
- p.Arg66Leu Single submitter ⚠
- p.Asn365Ser Single submitter ⚠
- p.Asn382Ser Single submitter ⚠
- p.Asp102Glu Single submitter ⚠
- p.Asp305Asn Single submitter ⚠
- p.Asp86Tyr Single submitter ⚠
- p.Cys96Tyr Single submitter ⚠
- p.Gln23His Single submitter ⚠
- p.Gln4His Single submitter ⚠
- p.Gln63His Single submitter ⚠
- p.Glu307Lys Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Glu378Lys Single submitter ⚠
- p.Gly132Cys Single submitter ⚠
- p.Gly204Ser Single submitter ⚠
- p.Gly233Ser Single submitter ⚠
- p.Gly287Asp Single submitter ⚠
- p.Gly290Cys Single submitter ⚠
- p.Gly290Val Single submitter ⚠
- p.Gly30Arg Single submitter ⚠
- p.Gly30Glu Single submitter ⚠
- p.Gly33Asp Single submitter ⚠
- p.Gly422Asp Single submitter ⚠
- p.Gly429Glu Single submitter ⚠
- p.His187Asp Single submitter ⚠
- p.His343Pro Single submitter ⚠
- p.Ile306Val Single submitter ⚠
- p.Ile400Val Single submitter ⚠
- p.Leu372Phe Single submitter ⚠
- p.Lys296Arg Single submitter ⚠
- p.Lys296Glu Single submitter ⚠
- p.Met151Ile Single submitter ⚠
- p.Met423Leu Single submitter ⚠
- p.Met446Thr Single submitter ⚠
- p.Phe242Leu Single submitter ⚠
- p.Phe252Cys Single submitter ⚠
- p.Phe389Leu Single submitter ⚠
- p.Pro159Ala Single submitter ⚠
- p.Pro210Thr Single submitter ⚠
- p.Pro216Ser Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro264Ser Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Pro58Arg Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Tyr334Cys Single submitter ⚠
- p.Tyr441Cys Single submitter ⚠
- p.Val19Phe Single submitter ⚠
- p.Val274Ala Single submitter ⚠
- p.Val283Ile Single submitter ⚠
- p.Val301Met Single submitter ⚠
- p.Val333Ile Single submitter ⚠
- p.Val340Met Single submitter ⚠
- p.Val390Met Single submitter ⚠