DENND1A — 160 ClinVar variants

All ClinVar germline DENND1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 143 flagged for review →

2 Benign · 7 Likely benign · 151 Uncertain significance

Full DENND1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 143

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 119

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All DENND1A variants

Benign 2

p.Ser722Leu Multiple submitters
p.Gly602= Single submitter

Likely benign 7

p.Ala434= Single submitter
p.Ala531Thr Single submitter
p.Ala864Thr Single submitter
p.Arg738Gln Single submitter
p.Gly679Arg Single submitter
p.Pro1009= Single submitter
p.Val635Ile Single submitter

Uncertain significance 151

p.Asp630Asn Multiple submitters ⚠
c.1631+1542dup Single submitter
p.Ala1051Pro Single submitter ⚠
p.Ala178Gly Single submitter ⚠
p.Ala215Val Single submitter ⚠
p.Ala309Ser Single submitter ⚠
p.Ala341Gly Single submitter ⚠
p.Ala358Ser Single submitter
p.Ala460Ser Single submitter ⚠
p.Ala460Thr Single submitter ⚠
p.Ala478Ser Single submitter ⚠
p.Ala600Val Single submitter ⚠
p.Ala790Val Single submitter ⚠
p.Ala842Val Single submitter ⚠
p.Ala918Asp Single submitter ⚠
p.Ala928Val Single submitter ⚠
p.Ala976Val Single submitter ⚠
p.Arg196Gln Single submitter ⚠
p.Arg347Cys Single submitter
p.Arg409Gln Single submitter ⚠
p.Arg448His Single submitter ⚠
p.Arg516Cys Single submitter ⚠
p.Arg516His Single submitter ⚠
p.Arg516Leu Single submitter ⚠
p.Arg519Cys Single submitter ⚠
p.Arg592Trp Single submitter ⚠
p.Arg613Trp Single submitter ⚠
p.Arg625Gln Single submitter ⚠
p.Arg625Trp Single submitter ⚠
p.Arg658Cys Single submitter
p.Arg658His Single submitter ⚠
p.Arg664Lys Single submitter ⚠
p.Arg684Cys Single submitter ⚠
p.Arg684His Single submitter ⚠
p.Arg738Trp Single submitter ⚠
p.Arg762Gln Single submitter ⚠
p.Arg781Cys Single submitter ⚠
p.Arg781Leu Single submitter ⚠
p.Arg798Gln Single submitter ⚠
p.Arg806Gly Single submitter ⚠
p.Arg862Cys Single submitter ⚠
p.Arg862His Single submitter ⚠
p.Arg983Gln Single submitter ⚠
p.Arg989Cys Single submitter ⚠
p.Asn129Lys Single submitter ⚠
p.Asn867Ile Single submitter ⚠
p.Asp142Val Single submitter ⚠
p.Asp271Gly Single submitter ⚠
p.Asp280Gly Single submitter
p.Asp30Gly Single submitter ⚠
p.Asp453Asn Single submitter ⚠
p.Asp624Asn Single submitter ⚠
p.Asp662Glu Single submitter ⚠
p.Asp804Asn Single submitter ⚠
p.Asp841Asn Single submitter ⚠
p.Gln1040Glu Single submitter ⚠
p.Gln283His Single submitter ⚠
p.Gln451Lys Single submitter
p.Gln666Arg Single submitter ⚠
p.Gln673Arg Single submitter ⚠
p.Glu10Asp Single submitter ⚠
p.Glu168Asp Single submitter ⚠
p.Glu465Lys Single submitter ⚠
p.Glu604Lys Single submitter ⚠
p.Glu642Gln Single submitter ⚠
p.Gly321Ser Single submitter
p.Gly380Ser Single submitter ⚠
p.Gly534Arg Single submitter ⚠
p.Gly685Arg Single submitter ⚠
p.Gly726Arg Single submitter ⚠
p.Gly772Val Single submitter ⚠
p.Gly917Arg Single submitter ⚠
p.His148Arg Single submitter ⚠
p.His437Arg Single submitter ⚠
p.Ile211Val Single submitter ⚠
p.Ile247Val Single submitter ⚠
p.Ile415Val Single submitter ⚠
p.Ile454Phe Single submitter ⚠
p.Ile454Val Single submitter ⚠
p.Ile490Phe Single submitter ⚠
p.Ile741Met Single submitter ⚠
p.Ile99Met Single submitter ⚠
p.Leu149Phe Single submitter
p.Leu826Phe Single submitter ⚠
p.Leu859Phe Single submitter ⚠
p.Lys1043Glu Single submitter ⚠
p.Lys256Asn Single submitter ⚠
p.Lys298Gln Single submitter ⚠
p.Lys399Thr Single submitter ⚠
p.Lys747Met Single submitter ⚠
p.Met243Ile Single submitter ⚠
p.Met254Leu Single submitter ⚠
p.Met641Val Single submitter ⚠
p.Met953Ile Single submitter ⚠
p.Met953Val Single submitter ⚠
p.Phe279Tyr Single submitter ⚠
p.Phe342Leu Single submitter ⚠
p.Phe878Leu Single submitter ⚠
p.Pro1009Arg Single submitter ⚠
p.Pro1009Leu Single submitter ⚠
p.Pro1028Ser Single submitter ⚠
p.Pro1048Ser Single submitter ⚠
p.Pro1054Leu Single submitter ⚠
p.Pro1056Thr Single submitter ⚠
p.Pro143Ser Single submitter ⚠
p.Pro232Thr Single submitter ⚠
p.Pro463Gln Single submitter ⚠
p.Pro472Gln Single submitter ⚠
p.Pro481Ser Single submitter ⚠
p.Pro608Thr Single submitter ⚠
p.Pro623Ala Single submitter ⚠
p.Pro695Leu Single submitter ⚠
p.Pro777Leu Single submitter ⚠
p.Pro782Leu Single submitter ⚠
p.Pro782Ser Single submitter ⚠
p.Pro828Leu Single submitter ⚠
p.Pro866Ala Single submitter ⚠
p.Pro874His Single submitter ⚠
p.Pro880Ala Single submitter ⚠
p.Pro884Ala Single submitter ⚠
p.Pro884Ser Single submitter ⚠
p.Pro912Thr Single submitter ⚠
p.Pro925Leu Single submitter ⚠
p.Pro961Ser Single submitter ⚠
p.Pro968Ala Single submitter ⚠
p.Ser1058Leu Single submitter ⚠
p.Ser1058Pro Single submitter ⚠
p.Ser165Gly Single submitter ⚠
p.Ser382Asn Single submitter ⚠
p.Ser382Ile Single submitter ⚠
p.Ser810Asn Single submitter ⚠
p.Ser830Asn Single submitter ⚠
p.Ser935Ile Single submitter ⚠
p.Ser980Leu Single submitter ⚠
p.Thr120Met Single submitter ⚠
p.Thr160Ser Single submitter ⚠
p.Thr302Ala Single submitter ⚠
p.Thr359Ile Single submitter ⚠
p.Thr693Ser Single submitter ⚠
p.Thr754Ile Single submitter ⚠
p.Thr768Asn Single submitter ⚠
p.Thr823Ser Single submitter ⚠
p.Thr838Met Single submitter ⚠
p.Thr852Lys Single submitter ⚠
p.Thr966Met Single submitter ⚠
p.Trp854Cys Single submitter ⚠
p.Tyr58Cys Single submitter ⚠
p.Val33Leu Single submitter ⚠
p.Val476Met Single submitter ⚠
p.Val515Leu Single submitter ⚠
p.Val774Met Single submitter ⚠