DENND1B — 50 ClinVar variants
All ClinVar germline DENND1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
3 Benign · 3 Likely benign · 44 Uncertain significance
Full DENND1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND1B p.Ala327Pro Uncertain significance Single submitter
- DENND1B p.Ala394Gly Uncertain significance Single submitter
- DENND1B p.Ala394Ser Uncertain significance Single submitter
- DENND1B p.Arg332Thr Uncertain significance Single submitter
- DENND1B p.Arg388Gln Uncertain significance Single submitter
- DENND1B p.Cys52Tyr Uncertain significance Single submitter
- DENND1B p.Gly395Glu Uncertain significance Single submitter
- DENND1B p.Ile244Met Uncertain significance Single submitter
- DENND1B p.Ile272Arg Uncertain significance Single submitter
- DENND1B p.Ile406Asn Uncertain significance Single submitter
- DENND1B p.Ile93Val Uncertain significance Single submitter
- DENND1B p.Lys109Gln Uncertain significance Single submitter
- DENND1B p.Pro144Ser Uncertain significance Single submitter
- DENND1B p.Pro169Leu Uncertain significance Single submitter
- DENND1B p.Ser305Thr Uncertain significance Single submitter
- DENND1B p.Thr74Ile Uncertain significance Single submitter
- DENND1B p.Tyr240Phe Uncertain significance Single submitter
- DENND1B p.Tyr245His Uncertain significance Single submitter
- DENND1B p.Val367Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- DENND1B p.Ala175Gly Uncertain significance Single submitter
- DENND1B p.Ala310Val Uncertain significance Single submitter
- DENND1B p.Arg274Ile Uncertain significance Single submitter
- DENND1B p.Arg721Trp Uncertain significance Single submitter
- DENND1B p.Asn142His Uncertain significance Single submitter
- DENND1B p.Asn313Lys Uncertain significance Single submitter
- DENND1B p.Asp343Asn Uncertain significance Single submitter
- DENND1B p.Cys21Ser Uncertain significance Single submitter
- DENND1B p.Cys356Arg Uncertain significance Single submitter
- DENND1B p.Glu77Lys Uncertain significance Single submitter
- DENND1B p.Gly397Ser Uncertain significance Single submitter
- DENND1B p.Leu235Phe Uncertain significance Single submitter
- DENND1B p.Leu264Val Uncertain significance Single submitter
- DENND1B p.Leu300Trp Uncertain significance Single submitter
- DENND1B p.Leu572Val Uncertain significance Single submitter
- DENND1B p.Met202Val Uncertain significance Single submitter
- DENND1B p.Pro139Ala Uncertain significance Single submitter
- DENND1B p.Ser220Gly Uncertain significance Single submitter
- DENND1B p.Ser309Leu Uncertain significance Single submitter
- DENND1B p.Thr12Ile Uncertain significance Single submitter
- DENND1B p.Thr183Pro Uncertain significance Single submitter
- DENND1B p.Thr290Arg Uncertain significance Single submitter
- DENND1B p.Thr88Met Uncertain significance Single submitter
- DENND1B p.Val307Ala Uncertain significance Single submitter
All DENND1B variants
Benign 3
- p.Leu254= Multiple submitters
- p.Met597Val Multiple submitters
- p.Ser652= Multiple submitters
Likely benign 3
- p.Cys258= Single submitter
- p.Ile44Val Single submitter
- p.Ser47= Single submitter
Uncertain significance 44
- p.Ala175Gly Single submitter ⚠
- p.Ala310Val Single submitter ⚠
- p.Ala327Pro Single submitter ⚠
- p.Ala394Gly Single submitter ⚠
- p.Ala394Ser Single submitter ⚠
- p.Arg274Ile Single submitter ⚠
- p.Arg332Thr Single submitter ⚠
- p.Arg388Gln Single submitter ⚠
- p.Arg721Trp Single submitter ⚠
- p.Asn142His Single submitter ⚠
- p.Asn313Lys Single submitter ⚠
- p.Asp343Asn Single submitter ⚠
- p.Cys21Ser Single submitter ⚠
- p.Cys356Arg Single submitter ⚠
- p.Cys52Tyr Single submitter ⚠
- p.Glu77Lys Single submitter ⚠
- p.Gly395Glu Single submitter ⚠
- p.Gly397Ser Single submitter ⚠
- p.Ile244Met Single submitter ⚠
- p.Ile272Arg Single submitter ⚠
- p.Ile406Asn Single submitter ⚠
- p.Ile93Val Single submitter ⚠
- p.Leu235Phe Single submitter ⚠
- p.Leu264Val Single submitter ⚠
- p.Leu300Trp Single submitter ⚠
- p.Leu572Val Single submitter ⚠
- p.Lys109Gln Single submitter ⚠
- p.Met202Val Single submitter ⚠
- p.Pro139Ala Single submitter ⚠
- p.Pro144Ser Single submitter ⚠
- p.Pro169Leu Single submitter ⚠
- p.Ser220Gly Single submitter ⚠
- p.Ser305Thr Single submitter ⚠
- p.Ser309Leu Single submitter ⚠
- p.Thr12Ile Single submitter ⚠
- p.Thr183Pro Single submitter ⚠
- p.Thr290Arg Single submitter ⚠
- p.Thr74Ile Single submitter ⚠
- p.Thr88Met Single submitter ⚠
- p.Tyr240Phe Single submitter ⚠
- p.Tyr245His Single submitter ⚠
- p.Val307Ala Single submitter ⚠
- p.Val367Met Single submitter ⚠
- c.447+1G>T No assertion criteria autism