DENND1C — 124 ClinVar variants
All ClinVar germline DENND1C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →
13 Likely benign · 111 Uncertain significance
Full DENND1C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 110
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 99
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND1C p.Ala292Thr Uncertain significance Single submitter
- DENND1C p.Ala321Ser Uncertain significance Single submitter
- DENND1C p.Ala373Ser Uncertain significance Single submitter
- DENND1C p.Ala378Ser Uncertain significance Single submitter
- DENND1C p.Ala418Ser Uncertain significance Single submitter
- DENND1C p.Ala455Val Uncertain significance Single submitter
- DENND1C p.Ala571Thr Uncertain significance Single submitter
- DENND1C p.Ala65Thr Uncertain significance Single submitter
- DENND1C p.Ala760Thr Uncertain significance Single submitter
- DENND1C p.Ala793Thr Uncertain significance Single submitter
- DENND1C p.Arg278Gly Uncertain significance Single submitter
- DENND1C p.Arg316Gln Uncertain significance Single submitter
- DENND1C p.Arg33Gln Uncertain significance Single submitter
- DENND1C p.Arg376Gln Uncertain significance Single submitter
- DENND1C p.Arg376Leu Uncertain significance Single submitter
- DENND1C p.Arg377Gln Uncertain significance Single submitter
- DENND1C p.Arg391Gln Uncertain significance Single submitter
- DENND1C p.Arg492Gly Uncertain significance Single submitter
- DENND1C p.Arg492His Uncertain significance Single submitter
- DENND1C p.Arg507Gln Uncertain significance Single submitter
- DENND1C p.Arg510Cys Uncertain significance Single submitter
- DENND1C p.Arg515Cys Uncertain significance Single submitter
- DENND1C p.Arg639Ser Uncertain significance Single submitter
- DENND1C p.Arg750Trp Uncertain significance Single submitter
- DENND1C p.Arg765Trp Uncertain significance Single submitter
- DENND1C p.Arg789Gly Uncertain significance Single submitter
- DENND1C p.Arg789Trp Uncertain significance Single submitter
- DENND1C p.Asn428Ser Uncertain significance Single submitter
- DENND1C p.Asp427Asn Uncertain significance Single submitter
- DENND1C p.Asp592Glu Uncertain significance Single submitter
- DENND1C p.Asp606Asn Uncertain significance Single submitter
- DENND1C p.Asp607Asn Uncertain significance Single submitter
- DENND1C p.Asp669Tyr Uncertain significance Single submitter
- DENND1C p.Cys594Tyr Uncertain significance Single submitter
- DENND1C p.Cys85Arg Uncertain significance Single submitter
- DENND1C p.Cys94Tyr Uncertain significance Single submitter
- DENND1C p.Gln122Lys Uncertain significance Single submitter
- DENND1C p.Gln136His Uncertain significance Single submitter
- DENND1C p.Gln42Arg Uncertain significance Single submitter
- DENND1C p.Gln501His Uncertain significance Single submitter
- DENND1C p.Glu389Gln Uncertain significance Single submitter
- DENND1C p.Glu406Lys Uncertain significance Single submitter
- DENND1C p.Glu523Lys Uncertain significance Single submitter
- DENND1C p.Glu537Asp Uncertain significance Single submitter
- DENND1C p.Glu745Lys Uncertain significance Single submitter
- DENND1C p.Gly158Arg Uncertain significance Single submitter
- DENND1C p.Gly160Ser Uncertain significance Single submitter
- DENND1C p.Gly167Arg Uncertain significance Single submitter
- DENND1C p.Gly181Arg Uncertain significance Single submitter
- DENND1C p.Gly400Asp Uncertain significance Single submitter
- DENND1C p.Gly413Arg Uncertain significance Single submitter
- DENND1C p.Gly478Arg Uncertain significance Single submitter
- DENND1C p.Gly479Asp Uncertain significance Single submitter
- DENND1C p.Gly78Asp Uncertain significance Single submitter
- DENND1C p.Gly801Asp Uncertain significance Single submitter
- DENND1C p.Gly8Cys Uncertain significance Single submitter
- DENND1C p.Ile161Thr Uncertain significance Single submitter
- DENND1C p.Ile267Thr Uncertain significance Single submitter
- DENND1C p.Ile499Val Uncertain significance Single submitter
- DENND1C p.Leu111Phe Uncertain significance Single submitter
- DENND1C p.Met569Thr Uncertain significance Single submitter
- DENND1C p.Pro141Ser Uncertain significance Single submitter
- DENND1C p.Pro162Arg Uncertain significance Single submitter
- DENND1C p.Pro163Arg Uncertain significance Single submitter
- DENND1C p.Pro163His Uncertain significance Single submitter
- DENND1C p.Pro171Arg Uncertain significance Single submitter
- DENND1C p.Pro184Thr Uncertain significance Single submitter
- DENND1C p.Pro22Ala Uncertain significance Single submitter
- DENND1C p.Pro249Leu Uncertain significance Single submitter
- DENND1C p.Pro37Leu Uncertain significance Single submitter
- DENND1C p.Pro534Arg Uncertain significance Single submitter
- DENND1C p.Pro613Gln Uncertain significance Single submitter
- DENND1C p.Pro613Leu Uncertain significance Single submitter
- DENND1C p.Pro61Ser Uncertain significance Single submitter
- DENND1C p.Pro701Thr Uncertain significance Single submitter
- DENND1C p.Pro707Thr Uncertain significance Single submitter
- DENND1C p.Pro752His Uncertain significance Single submitter
- DENND1C p.Pro768Ser Uncertain significance Single submitter
- DENND1C p.Pro777Ser Uncertain significance Single submitter
- DENND1C p.Ser173Thr Uncertain significance Single submitter
- DENND1C p.Ser234Cys Uncertain significance Single submitter
- DENND1C p.Ser358Asn Uncertain significance Single submitter
- DENND1C p.Ser3Phe Uncertain significance Single submitter
- DENND1C p.Ser402Leu Uncertain significance Single submitter
- DENND1C p.Ser473Pro Uncertain significance Single submitter
- DENND1C p.Ser568Gly Uncertain significance Single submitter
- DENND1C p.Ser593Asn Uncertain significance Single submitter
- DENND1C p.Ser619Cys Uncertain significance Single submitter
- DENND1C p.Ser622Pro Uncertain significance Single submitter
- DENND1C p.Ser635Pro Uncertain significance Single submitter
- DENND1C p.Ser638Ala Uncertain significance Single submitter
- DENND1C p.Ser63Gly Uncertain significance Single submitter
- DENND1C p.Ser9Phe Uncertain significance Single submitter
- DENND1C p.Thr154Met Uncertain significance Single submitter
- DENND1C p.Thr193Arg Uncertain significance Single submitter
- DENND1C p.Thr778Asn Uncertain significance Single submitter
- DENND1C p.Trp541Gly Uncertain significance Single submitter
- DENND1C p.Val205Met Uncertain significance Single submitter
- DENND1C p.Val448Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DENND1C p.Arg376Trp Uncertain significance Single submitter
- DENND1C p.Arg86Cys Uncertain significance Single submitter
- DENND1C p.Asn293Ser Uncertain significance Single submitter
- DENND1C p.Gln386Arg Uncertain significance Single submitter
- DENND1C p.Glu562Lys Uncertain significance Single submitter
- DENND1C p.His68Asn Uncertain significance Single submitter
- DENND1C p.Pro351Arg Uncertain significance Single submitter
- DENND1C p.Ser582Cys Uncertain significance Single submitter
- DENND1C p.Val231Phe Uncertain significance Single submitter
- DENND1C p.Val285Ile Uncertain significance Single submitter
- DENND1C p.Val66Met Uncertain significance Single submitter
All DENND1C variants
Likely benign 13
- p.Ala574Thr Single submitter
- p.Arg789Gln Single submitter
- p.Glu6= Single submitter
- p.Leu227= Single submitter
- p.Pro141Thr Single submitter
- p.Ser137Pro Single submitter
- p.Ser99= Single submitter
- p.Thr154Lys Single submitter
- p.Thr700Ala Single submitter
- p.Thr91Ala Single submitter
- p.Val287Met Single submitter
- p.Val462Met Single submitter
- p.Val651Ile Single submitter
Uncertain significance 111
- p.Ala292Thr Single submitter ⚠
- p.Ala321Ser Single submitter ⚠
- p.Ala373Ser Single submitter ⚠
- p.Ala378Ser Single submitter ⚠
- p.Ala418Ser Single submitter ⚠
- p.Ala455Val Single submitter ⚠
- p.Ala571Thr Single submitter ⚠
- p.Ala65Thr Single submitter ⚠
- p.Ala760Thr Single submitter ⚠
- p.Ala793Thr Single submitter ⚠
- p.Arg278Gly Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg376Gln Single submitter ⚠
- p.Arg376Leu Single submitter ⚠
- p.Arg376Trp Single submitter ⚠
- p.Arg377Gln Single submitter ⚠
- p.Arg391Gln Single submitter ⚠
- p.Arg492Gly Single submitter ⚠
- p.Arg492His Single submitter ⚠
- p.Arg507Gln Single submitter ⚠
- p.Arg510Cys Single submitter ⚠
- p.Arg515Cys Single submitter ⚠
- p.Arg639Ser Single submitter ⚠
- p.Arg750Trp Single submitter ⚠
- p.Arg765Trp Single submitter ⚠
- p.Arg789Gly Single submitter ⚠
- p.Arg789Trp Single submitter ⚠
- p.Arg86Cys Single submitter ⚠
- p.Asn293Ser Single submitter ⚠
- p.Asn428Ser Single submitter ⚠
- p.Asp427Asn Single submitter ⚠
- p.Asp592Glu Single submitter ⚠
- p.Asp606Asn Single submitter ⚠
- p.Asp607Asn Single submitter ⚠
- p.Asp669Tyr Single submitter ⚠
- p.Cys594Tyr Single submitter ⚠
- p.Cys85Arg Single submitter ⚠
- p.Cys94Tyr Single submitter ⚠
- p.Gln122Lys Single submitter ⚠
- p.Gln136His Single submitter ⚠
- p.Gln386Arg Single submitter ⚠
- p.Gln42Arg Single submitter ⚠
- p.Gln501His Single submitter ⚠
- p.Glu389Gln Single submitter ⚠
- p.Glu406Lys Single submitter ⚠
- p.Glu523Lys Single submitter ⚠
- p.Glu537Asp Single submitter ⚠
- p.Glu562Lys Single submitter ⚠
- p.Glu745Lys Single submitter ⚠
- p.Gly158Arg Single submitter ⚠
- p.Gly160Ser Single submitter ⚠
- p.Gly167Arg Single submitter ⚠
- p.Gly181Arg Single submitter ⚠
- p.Gly400Asp Single submitter ⚠
- p.Gly413Arg Single submitter ⚠
- p.Gly432Asp Single submitter
- p.Gly478Arg Single submitter ⚠
- p.Gly479Asp Single submitter ⚠
- p.Gly78Asp Single submitter ⚠
- p.Gly801Asp Single submitter ⚠
- p.Gly8Cys Single submitter ⚠
- p.His68Asn Single submitter ⚠
- p.Ile161Thr Single submitter ⚠
- p.Ile267Thr Single submitter ⚠
- p.Ile499Val Single submitter ⚠
- p.Leu111Phe Single submitter ⚠
- p.Met569Thr Single submitter ⚠
- p.Pro141Ser Single submitter ⚠
- p.Pro162Arg Single submitter ⚠
- p.Pro163Arg Single submitter ⚠
- p.Pro163His Single submitter ⚠
- p.Pro171Arg Single submitter ⚠
- p.Pro184Thr Single submitter ⚠
- p.Pro22Ala Single submitter ⚠
- p.Pro249Leu Single submitter ⚠
- p.Pro351Arg Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro534Arg Single submitter ⚠
- p.Pro613Gln Single submitter ⚠
- p.Pro613Leu Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Pro701Thr Single submitter ⚠
- p.Pro707Thr Single submitter ⚠
- p.Pro752His Single submitter ⚠
- p.Pro768Ser Single submitter ⚠
- p.Pro777Ser Single submitter ⚠
- p.Ser173Thr Single submitter ⚠
- p.Ser234Cys Single submitter ⚠
- p.Ser358Asn Single submitter ⚠
- p.Ser3Phe Single submitter ⚠
- p.Ser402Leu Single submitter ⚠
- p.Ser473Pro Single submitter ⚠
- p.Ser568Gly Single submitter ⚠
- p.Ser582Cys Single submitter ⚠
- p.Ser593Asn Single submitter ⚠
- p.Ser619Cys Single submitter ⚠
- p.Ser622Pro Single submitter ⚠
- p.Ser635Pro Single submitter ⚠
- p.Ser638Ala Single submitter ⚠
- p.Ser63Gly Single submitter ⚠
- p.Ser9Phe Single submitter ⚠
- p.Thr154Met Single submitter ⚠
- p.Thr193Arg Single submitter ⚠
- p.Thr778Asn Single submitter ⚠
- p.Trp541Gly Single submitter ⚠
- p.Val205Met Single submitter ⚠
- p.Val231Phe Single submitter ⚠
- p.Val285Ile Single submitter ⚠
- p.Val448Ile Single submitter ⚠
- p.Val66Met Single submitter ⚠