DENND2A — 154 ClinVar variants

All ClinVar germline DENND2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 140 flagged for review →

6 Likely benign · 148 Uncertain significance

Full DENND2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 140

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 118

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 22

The independent predictors disagree with each other — read with care.

All DENND2A variants

Likely benign 6

p.Ala793Thr Single submitter
p.Arg245Gln Single submitter
p.Asp193Glu Single submitter
p.Gly102Glu Single submitter
p.Gly125Arg Single submitter
p.Pro229Ser Single submitter

Uncertain significance 148

c.1779+8G>A Single submitter
p.Ala276Gly Single submitter ⚠
p.Ala422Val Single submitter ⚠
p.Ala68Thr Single submitter ⚠
p.Ala784Glu Single submitter ⚠
p.Ala784Thr Single submitter ⚠
p.Arg110Ser Single submitter ⚠
p.Arg141Gln Single submitter ⚠
p.Arg151His Single submitter ⚠
p.Arg270Trp Single submitter ⚠
p.Arg290Gly Single submitter ⚠
p.Arg294Ile Single submitter ⚠
p.Arg40Gln Single submitter ⚠
p.Arg40Trp Single submitter ⚠
p.Arg425Gln Single submitter ⚠
p.Arg443Gln Single submitter ⚠
p.Arg494Gln Single submitter ⚠
p.Arg494Trp Single submitter
p.Arg499Trp Single submitter ⚠
p.Arg535Cys Single submitter
p.Arg535His Single submitter ⚠
p.Arg542Leu Single submitter ⚠
p.Arg548Gln Single submitter ⚠
p.Arg562Ser Single submitter ⚠
p.Arg645Thr Single submitter ⚠
p.Arg670Cys Single submitter ⚠
p.Arg737Gln Single submitter ⚠
p.Arg845Gln Single submitter ⚠
p.Arg845Trp Single submitter ⚠
p.Arg859Trp Single submitter ⚠
p.Arg962Gln Single submitter ⚠
p.Arg962Trp Single submitter ⚠
p.Arg965His Single submitter ⚠
p.Arg966Gln Single submitter ⚠
p.Asn1001Asp Single submitter ⚠
p.Asn204Lys Single submitter ⚠
p.Asn249Lys Single submitter ⚠
p.Asn381Lys Single submitter ⚠
p.Asn488Ile Single submitter ⚠
p.Asn97Asp Single submitter ⚠
p.Asp155His Single submitter ⚠
p.Asp372Gly Single submitter ⚠
p.Asp641Gly Single submitter ⚠
p.Asp773Glu Single submitter ⚠
p.Asp808Asn Single submitter ⚠
p.Asp852Asn Single submitter
p.Asp968Val Single submitter ⚠
p.Cys190Tyr Single submitter ⚠
p.Cys392Arg Single submitter
p.Cys782Arg Single submitter ⚠
p.Cys811Ser Single submitter ⚠
p.Gln126Lys Single submitter ⚠
p.Gln29Arg Single submitter ⚠
p.Gln416Lys Single submitter ⚠
p.Gln534Arg Single submitter ⚠
p.Glu744Lys Single submitter ⚠
p.Glu874Gln Single submitter ⚠
p.Glu874Lys Single submitter ⚠
p.Glu909Gly Single submitter ⚠
p.Glu922Lys Single submitter ⚠
p.Glu947Asp Single submitter ⚠
p.Gly118Val Single submitter ⚠
p.Gly119Glu Single submitter ⚠
p.Gly148Asp Single submitter ⚠
p.Gly210Ala Single submitter ⚠
p.Gly237Cys Single submitter ⚠
p.Gly256Asp Single submitter ⚠
p.Gly277Arg Single submitter ⚠
p.Gly323Arg Single submitter ⚠
p.Gly474Ser Single submitter ⚠
p.Gly647Ser Single submitter ⚠
p.Gly998Arg Single submitter ⚠
p.His389Leu Single submitter ⚠
p.Ile771Met Single submitter ⚠
p.Ile771Thr Single submitter ⚠
p.Ile799Val Single submitter ⚠
p.Leu128Pro Single submitter ⚠
p.Leu147Phe Single submitter ⚠
p.Leu358Met Single submitter ⚠
p.Leu374Pro Single submitter ⚠
p.Leu435Val Single submitter ⚠
p.Leu543Gln Single submitter ⚠
p.Leu827Pro Single submitter ⚠
p.Leu831Pro Single submitter ⚠
p.Leu884Val Single submitter ⚠
p.Lys281Glu Single submitter ⚠
p.Lys420Glu Single submitter ⚠
p.Lys47Thr Single submitter ⚠
p.Lys657Glu Single submitter
p.Lys997Asn Single submitter ⚠
p.Met378Val Single submitter ⚠
p.Met601Ile Single submitter ⚠
p.Met699Leu Single submitter
p.Met8Val Single submitter ⚠
p.Phe337Tyr Single submitter ⚠
p.Phe565Leu Single submitter ⚠
p.Phe598Leu Single submitter ⚠
p.Phe917Leu Single submitter ⚠
p.Pro124Leu Single submitter ⚠
p.Pro188Ser Single submitter ⚠
p.Pro219Thr Single submitter ⚠
p.Pro229Ala Single submitter ⚠
p.Pro305Leu Single submitter ⚠
p.Pro311Ser Single submitter ⚠
p.Pro33Thr Single submitter ⚠
p.Pro550Leu Single submitter ⚠
p.Pro76Leu Single submitter ⚠
p.Pro832Leu Single submitter ⚠
p.Ser138Thr Single submitter ⚠
p.Ser18Arg Single submitter ⚠
p.Ser246Arg Single submitter ⚠
p.Ser314Phe Single submitter ⚠
p.Ser315Ala Single submitter ⚠
p.Ser442Arg Single submitter ⚠
p.Ser448Phe Single submitter ⚠
p.Ser634Ala Single submitter ⚠
p.Ser745Cys Single submitter ⚠
p.Ser745Phe Single submitter ⚠
p.Ser751Gly Single submitter ⚠
p.Ser892Tyr Single submitter ⚠
p.Ser920Leu Single submitter ⚠
p.Ser920Trp Single submitter ⚠
p.Thr363Ala Single submitter ⚠
p.Thr438Ile Single submitter ⚠
p.Thr814Met Single submitter ⚠
p.Thr919Met Single submitter ⚠
p.Thr927Pro Single submitter ⚠
p.Thr927Ser Single submitter ⚠
p.Trp139Arg Single submitter ⚠
p.Trp243Arg Single submitter ⚠
p.Tyr353His Single submitter ⚠
p.Tyr549Asn Single submitter ⚠
p.Val135Met Single submitter ⚠
p.Val232Gly Single submitter ⚠
p.Val350Gly Single submitter ⚠
p.Val369Ile Single submitter ⚠
p.Val539Met Single submitter ⚠
p.Val583Leu Single submitter ⚠
p.Val583Met Single submitter ⚠
p.Val668Met Single submitter ⚠
p.Val741Met Single submitter ⚠
p.Val752Ile Single submitter ⚠
p.Val752Leu Single submitter ⚠
p.Val758Ala Single submitter
p.Val842Ile Single submitter ⚠
p.Val908Met Single submitter ⚠
p.Val937Ile Single submitter ⚠
p.Val948Ile Single submitter ⚠