DENND2C — 125 ClinVar variants
All ClinVar germline DENND2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 118 flagged for review →
1 Benign · 1 Likely benign · 123 Uncertain significance
Full DENND2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 118
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 96
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND2C p.Ala155Thr Uncertain significance Single submitter
- DENND2C p.Ala338Pro Uncertain significance Single submitter
- DENND2C p.Ala344Ser Uncertain significance Single submitter
- DENND2C p.Ala64Thr Uncertain significance Single submitter
- DENND2C p.Arg120Gln Uncertain significance Single submitter
- DENND2C p.Arg283Gln Uncertain significance Single submitter
- DENND2C p.Arg283Trp Uncertain significance Single submitter
- DENND2C p.Arg458His Uncertain significance Single submitter
- DENND2C p.Arg461His Uncertain significance Single submitter
- DENND2C p.Arg480Gln Uncertain significance Single submitter
- DENND2C p.Arg570Gln Uncertain significance Single submitter
- DENND2C p.Arg57His Uncertain significance Single submitter
- DENND2C p.Arg658Gln Uncertain significance Single submitter
- DENND2C p.Arg692Cys Uncertain significance Single submitter
- DENND2C p.Arg798Gln Uncertain significance Single submitter
- DENND2C p.Arg842His Uncertain significance Single submitter
- DENND2C p.Arg859Gln Uncertain significance Single submitter
- DENND2C p.Arg884Trp Uncertain significance Single submitter
- DENND2C p.Arg895Trp Uncertain significance Single submitter
- DENND2C p.Asn308Ser Uncertain significance Single submitter
- DENND2C p.Asn457Ser Uncertain significance Single submitter
- DENND2C p.Asn601Ser Uncertain significance Single submitter
- DENND2C p.Asn61Asp Uncertain significance Single submitter
- DENND2C p.Asn699Ser Uncertain significance Single submitter
- DENND2C p.Asn912Ser Uncertain significance Single submitter
- DENND2C p.Asp234Gly Uncertain significance Single submitter
- DENND2C p.Asp520Tyr Uncertain significance Single submitter
- DENND2C p.Asp668Asn Uncertain significance Single submitter
- DENND2C p.Cys203Tyr Uncertain significance Single submitter
- DENND2C p.Cys233Tyr Uncertain significance Single submitter
- DENND2C p.Cys243Tyr Uncertain significance Single submitter
- DENND2C p.Cys42Trp Uncertain significance Single submitter
- DENND2C p.Gln304Arg Uncertain significance Single submitter
- DENND2C p.Gln511Arg Uncertain significance Single submitter
- DENND2C p.Gln804Glu Uncertain significance Single submitter
- DENND2C p.Gln872Pro Uncertain significance Single submitter
- DENND2C p.Glu101Asp Uncertain significance Single submitter
- DENND2C p.Glu230Asp Uncertain significance Single submitter
- DENND2C p.Glu311Lys Uncertain significance Single submitter
- DENND2C p.Glu615Gly Uncertain significance Single submitter
- DENND2C p.Glu615Lys Uncertain significance Single submitter
- DENND2C p.Glu775Gln Uncertain significance Single submitter
- DENND2C p.Glu841Ala Uncertain significance Single submitter
- DENND2C p.Gly224Cys Uncertain significance Single submitter
- DENND2C p.Gly523Ser Uncertain significance Single submitter
- DENND2C p.His279Asn Uncertain significance Single submitter
- DENND2C p.His430Arg Uncertain significance Single submitter
- DENND2C p.His430Tyr Uncertain significance Single submitter
- DENND2C p.His474Arg Uncertain significance Single submitter
- DENND2C p.His90Arg Uncertain significance Single submitter
- DENND2C p.His90Tyr Uncertain significance Single submitter
- DENND2C p.Ile124Val Uncertain significance Single submitter
- DENND2C p.Ile417Leu Uncertain significance Single submitter
- DENND2C p.Ile682Val Uncertain significance Single submitter
- DENND2C p.Ile733Thr Uncertain significance Single submitter
- DENND2C p.Ile744Thr Uncertain significance Single submitter
- DENND2C p.Ile764Met Uncertain significance Single submitter
- DENND2C p.Ile903Val Uncertain significance Single submitter
- DENND2C p.Leu292Arg Uncertain significance Single submitter
- DENND2C p.Leu728Pro Uncertain significance Single submitter
- DENND2C p.Leu791Val Uncertain significance Single submitter
- DENND2C p.Leu802Phe Uncertain significance Single submitter
- DENND2C p.Leu883Val Uncertain significance Single submitter
- DENND2C p.Lys174Thr Uncertain significance Single submitter
- DENND2C p.Lys502Gln Uncertain significance Single submitter
- DENND2C p.Lys612Thr Uncertain significance Single submitter
- DENND2C p.Lys771Arg Uncertain significance Single submitter
- DENND2C p.Met530Val Uncertain significance Single submitter
- DENND2C p.Phe107Val Uncertain significance Single submitter
- DENND2C p.Phe516Leu Uncertain significance Single submitter
- DENND2C p.Phe603Ser Uncertain significance Single submitter
- DENND2C p.Pro139Ser Uncertain significance Single submitter
- DENND2C p.Pro227Leu Uncertain significance Single submitter
- DENND2C p.Pro331Leu Uncertain significance Single submitter
- DENND2C p.Pro343Ser Uncertain significance Single submitter
- DENND2C p.Pro503Thr Uncertain significance Single submitter
- DENND2C p.Pro618Ser Uncertain significance Single submitter
- DENND2C p.Pro62Leu Uncertain significance Single submitter
- DENND2C p.Pro634Ser Uncertain significance Single submitter
- DENND2C p.Pro636Thr Uncertain significance Single submitter
- DENND2C p.Ser251Phe Uncertain significance Single submitter
- DENND2C p.Ser420Tyr Uncertain significance Single submitter
- DENND2C p.Ser595Asn Uncertain significance Single submitter
- DENND2C p.Ser644Asn Uncertain significance Single submitter
- DENND2C p.Ser653Phe Uncertain significance Single submitter
- DENND2C p.Thr12Arg Uncertain significance Single submitter
- DENND2C p.Thr287Met Uncertain significance Single submitter
- DENND2C p.Thr287Pro Uncertain significance Single submitter
- DENND2C p.Thr8Ile Uncertain significance Single submitter
- DENND2C p.Tyr144Cys Uncertain significance Single submitter
- DENND2C p.Tyr195Cys Uncertain significance Single submitter
- DENND2C p.Tyr524Cys Uncertain significance Single submitter
- DENND2C p.Tyr716Cys Uncertain significance Single submitter
- DENND2C p.Val10Gly Uncertain significance Single submitter
- DENND2C p.Val512Ile Uncertain significance Single submitter
- DENND2C p.Val861Ile Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- DENND2C p.Arg214Cys Uncertain significance Single submitter
- DENND2C p.Arg266Ser Uncertain significance Single submitter
- DENND2C p.Arg480Trp Uncertain significance Single submitter
- DENND2C p.Arg638His Uncertain significance Single submitter
- DENND2C p.Arg916Pro Uncertain significance Single submitter
- DENND2C p.Arg916Trp Uncertain significance Single submitter
- DENND2C p.Asp276His Uncertain significance Single submitter
- DENND2C p.Asp312Asn Uncertain significance Single submitter
- DENND2C p.Asp324Gly Uncertain significance Single submitter
- DENND2C p.Glu532Lys Uncertain significance Single submitter
- DENND2C p.Glu589Lys Uncertain significance Single submitter
- DENND2C p.Gly141Glu Uncertain significance Single submitter
- DENND2C p.Gly423Arg Uncertain significance Single submitter
- DENND2C p.Ile483Thr Uncertain significance Single submitter
- DENND2C p.Ile794Asn Uncertain significance Single submitter
- DENND2C p.Lys24Thr Uncertain significance Single submitter
- DENND2C p.Lys421Glu Uncertain significance Single submitter
- DENND2C p.Lys424Met Uncertain significance Single submitter
- DENND2C p.Pro623Ala Uncertain significance Single submitter
- DENND2C p.Ser886Arg Uncertain significance Single submitter
- DENND2C p.Ser917Arg Uncertain significance Single submitter
- DENND2C p.Val736Met Uncertain significance Single submitter
All DENND2C variants
Benign 1
- p.Asn447= Single submitter
Likely benign 1
- p.Gly505Glu Single submitter
Uncertain significance 123
- p.Ala155Thr Single submitter ⚠
- p.Ala338Pro Single submitter ⚠
- p.Ala344Ser Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg214Cys Single submitter ⚠
- p.Arg266Ser Single submitter ⚠
- p.Arg283Gln Single submitter ⚠
- p.Arg283Trp Single submitter ⚠
- p.Arg458His Single submitter ⚠
- p.Arg461His Single submitter ⚠
- p.Arg480Gln Single submitter ⚠
- p.Arg480Trp Single submitter ⚠
- p.Arg570Gln Single submitter ⚠
- p.Arg57His Single submitter ⚠
- p.Arg638His Single submitter ⚠
- p.Arg658Gln Single submitter ⚠
- p.Arg663Gln Single submitter
- p.Arg692Cys Single submitter ⚠
- p.Arg798Gln Single submitter ⚠
- p.Arg842His Single submitter ⚠
- p.Arg845Cys Single submitter
- p.Arg859Gln Single submitter ⚠
- p.Arg884Trp Single submitter ⚠
- p.Arg895Trp Single submitter ⚠
- p.Arg916Pro Single submitter ⚠
- p.Arg916Trp Single submitter ⚠
- p.Asn308Ser Single submitter ⚠
- p.Asn457Ser Single submitter ⚠
- p.Asn601Ser Single submitter ⚠
- p.Asn61Asp Single submitter ⚠
- p.Asn699Ser Single submitter ⚠
- p.Asn912Ser Single submitter ⚠
- p.Asp234Gly Single submitter ⚠
- p.Asp276His Single submitter ⚠
- p.Asp312Asn Single submitter ⚠
- p.Asp324Gly Single submitter ⚠
- p.Asp520Tyr Single submitter ⚠
- p.Asp668Asn Single submitter ⚠
- p.Cys203Tyr Single submitter ⚠
- p.Cys233Tyr Single submitter ⚠
- p.Cys243Tyr Single submitter ⚠
- p.Cys42Trp Single submitter ⚠
- p.Cys675Tyr Single submitter
- p.Gln304Arg Single submitter ⚠
- p.Gln511Arg Single submitter ⚠
- p.Gln804Glu Single submitter ⚠
- p.Gln872Pro Single submitter ⚠
- p.Glu101Asp Single submitter ⚠
- p.Glu230Asp Single submitter ⚠
- p.Glu311Lys Single submitter ⚠
- p.Glu532Lys Single submitter ⚠
- p.Glu589Lys Single submitter ⚠
- p.Glu615Gly Single submitter ⚠
- p.Glu615Lys Single submitter ⚠
- p.Glu775Gln Single submitter ⚠
- p.Glu779Lys Single submitter
- p.Glu841Ala Single submitter ⚠
- p.Gly141Glu Single submitter ⚠
- p.Gly224Cys Single submitter ⚠
- p.Gly423Arg Single submitter ⚠
- p.Gly523Ser Single submitter ⚠
- p.His279Asn Single submitter ⚠
- p.His430Arg Single submitter ⚠
- p.His430Tyr Single submitter ⚠
- p.His474Arg Single submitter ⚠
- p.His90Arg Single submitter ⚠
- p.His90Tyr Single submitter ⚠
- p.Ile124Val Single submitter ⚠
- p.Ile417Leu Single submitter ⚠
- p.Ile483Thr Single submitter ⚠
- p.Ile682Val Single submitter ⚠
- p.Ile733Thr Single submitter ⚠
- p.Ile744Thr Single submitter ⚠
- p.Ile764Met Single submitter ⚠
- p.Ile794Asn Single submitter ⚠
- p.Ile903Val Single submitter ⚠
- p.Leu292Arg Single submitter ⚠
- p.Leu728Pro Single submitter ⚠
- p.Leu791Val Single submitter ⚠
- p.Leu802Phe Single submitter ⚠
- p.Leu883Val Single submitter ⚠
- p.Lys174Thr Single submitter ⚠
- p.Lys24Thr Single submitter ⚠
- p.Lys421Glu Single submitter ⚠
- p.Lys424Met Single submitter ⚠
- p.Lys502Gln Single submitter ⚠
- p.Lys612Thr Single submitter ⚠
- p.Lys771Arg Single submitter ⚠
- p.Met530Val Single submitter ⚠
- p.Phe107Val Single submitter ⚠
- p.Phe516Leu Single submitter ⚠
- p.Phe603Ser Single submitter ⚠
- p.Phe825Tyr Single submitter
- p.Pro139Ser Single submitter ⚠
- p.Pro227Leu Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Pro343Ser Single submitter ⚠
- p.Pro503Thr Single submitter ⚠
- p.Pro618Ser Single submitter ⚠
- p.Pro623Ala Single submitter ⚠
- p.Pro62Leu Single submitter ⚠
- p.Pro634Ser Single submitter ⚠
- p.Pro636Thr Single submitter ⚠
- p.Ser251Phe Single submitter ⚠
- p.Ser420Tyr Single submitter ⚠
- p.Ser595Asn Single submitter ⚠
- p.Ser644Asn Single submitter ⚠
- p.Ser653Phe Single submitter ⚠
- p.Ser886Arg Single submitter ⚠
- p.Ser917Arg Single submitter ⚠
- p.Thr12Arg Single submitter ⚠
- p.Thr287Met Single submitter ⚠
- p.Thr287Pro Single submitter ⚠
- p.Thr8Ile Single submitter ⚠
- p.Tyr144Cys Single submitter ⚠
- p.Tyr195Cys Single submitter ⚠
- p.Tyr524Cys Single submitter ⚠
- p.Tyr716Cys Single submitter ⚠
- p.Val10Gly Single submitter ⚠
- p.Val512Ile Single submitter ⚠
- p.Val736Met Single submitter ⚠
- p.Val861Ile Single submitter ⚠