DENND2D — 64 ClinVar variants
All ClinVar germline DENND2D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
3 Likely benign · 61 Uncertain significance
Full DENND2D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND2D p.Ala112Thr Uncertain significance Single submitter
- DENND2D p.Ala144Thr Uncertain significance Single submitter
- DENND2D p.Ala182Val Uncertain significance Single submitter
- DENND2D p.Ala198Thr Uncertain significance Single submitter
- DENND2D p.Ala251Val Uncertain significance Single submitter
- DENND2D p.Ala32Asp Uncertain significance Single submitter
- DENND2D p.Ala391Val Uncertain significance Single submitter
- DENND2D p.Ala398Glu Uncertain significance Single submitter
- DENND2D p.Ala39Thr Uncertain significance Single submitter
- DENND2D p.Arg11Lys Uncertain significance Single submitter
- DENND2D p.Arg140Cys Uncertain significance Single submitter
- DENND2D p.Arg149Cys Uncertain significance Single submitter
- DENND2D p.Arg21Gln Uncertain significance Single submitter
- DENND2D p.Arg312His Uncertain significance Single submitter
- DENND2D p.Arg38Lys Uncertain significance Single submitter
- DENND2D p.Arg407Gly Uncertain significance Single submitter
- DENND2D p.Arg407Ile Uncertain significance Single submitter
- DENND2D p.Arg419Cys Uncertain significance Single submitter
- DENND2D p.Arg82Trp Uncertain significance Single submitter
- DENND2D p.Arg87Gln Uncertain significance Single submitter
- DENND2D p.Arg87Trp Uncertain significance Single submitter
- DENND2D p.Arg8Gln Uncertain significance Single submitter
- DENND2D p.Arg8Trp Uncertain significance Single submitter
- DENND2D p.Arg95Gln Uncertain significance Single submitter
- DENND2D p.Arg95Trp Uncertain significance Single submitter
- DENND2D p.Asn46Lys Uncertain significance Single submitter
- DENND2D p.Asp211Asn Uncertain significance Single submitter
- DENND2D p.Asp356Ala Uncertain significance Single submitter
- DENND2D p.Cys238Arg Uncertain significance Single submitter
- DENND2D p.Gln26Pro Uncertain significance Single submitter
- DENND2D p.Gln4His Uncertain significance Single submitter
- DENND2D p.Glu373Lys Uncertain significance Single submitter
- DENND2D p.Glu437Gly Uncertain significance Single submitter
- DENND2D p.Glu467Asp Uncertain significance Single submitter
- DENND2D p.Glu91Gln Uncertain significance Single submitter
- DENND2D p.Gly161Ser Uncertain significance Single submitter
- DENND2D p.Ile217Val Uncertain significance Single submitter
- DENND2D p.Leu454Arg Uncertain significance Single submitter
- DENND2D p.Leu58Pro Uncertain significance Single submitter
- DENND2D p.Lys134Arg Uncertain significance Single submitter
- DENND2D p.Lys34Glu Uncertain significance Single submitter
- DENND2D p.Lys366Arg Uncertain significance Single submitter
- DENND2D p.Met322Thr Uncertain significance Single submitter
- DENND2D p.Phe10Cys Uncertain significance Single submitter
- DENND2D p.Pro25Ala Uncertain significance Single submitter
- DENND2D p.Ser113Ala Uncertain significance Single submitter
- DENND2D p.Ser415Phe Uncertain significance Single submitter
- DENND2D p.Ser441Thr Uncertain significance Single submitter
- DENND2D p.Thr266Ala Uncertain significance Single submitter
- DENND2D p.Thr76Ile Uncertain significance Single submitter
- DENND2D p.Tyr393His Uncertain significance Single submitter
- DENND2D p.Val299Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All DENND2D variants
Likely benign 3
- p.Arg15His Single submitter
- p.Arg66His Single submitter
- p.Ile386Thr Single submitter
Uncertain significance 61
- p.Ala112Thr Single submitter ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala182Val Single submitter ⚠
- p.Ala198Thr Single submitter ⚠
- p.Ala251Val Single submitter ⚠
- p.Ala32Asp Single submitter ⚠
- p.Ala391Val Single submitter ⚠
- p.Ala398Glu Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Arg11Lys Single submitter ⚠
- p.Arg140Cys Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg21Gln Single submitter ⚠
- p.Arg312His Single submitter ⚠
- p.Arg38Lys Single submitter ⚠
- p.Arg396Trp Single submitter ⚠
- p.Arg407Gly Single submitter ⚠
- p.Arg407Ile Single submitter ⚠
- p.Arg419Cys Single submitter ⚠
- p.Arg82Trp Single submitter ⚠
- p.Arg87Gln Single submitter ⚠
- p.Arg87Trp Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Arg95Gln Single submitter ⚠
- p.Arg95Trp Single submitter ⚠
- p.Asn46Lys Single submitter ⚠
- p.Asp211Asn Single submitter ⚠
- p.Asp356Ala Single submitter ⚠
- p.Cys238Arg Single submitter ⚠
- p.Gln26Pro Single submitter ⚠
- p.Gln4His Single submitter ⚠
- p.Gln78Lys Single submitter
- p.Glu373Lys Single submitter ⚠
- p.Glu437Gly Single submitter ⚠
- p.Glu439Lys Single submitter ⚠
- p.Glu467Asp Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Glu91Gln Single submitter ⚠
- p.Gly145Val Single submitter
- p.Gly147Arg Single submitter
- p.Gly161Ser Single submitter ⚠
- p.Ile217Val Single submitter ⚠
- p.Leu358Phe Single submitter ⚠
- p.Leu454Arg Single submitter ⚠
- p.Leu58Pro Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Lys134Arg Single submitter ⚠
- p.Lys34Glu Single submitter ⚠
- p.Lys366Arg Single submitter ⚠
- p.Met322Thr Single submitter ⚠
- p.Phe10Cys Single submitter ⚠
- p.Pro25Ala Single submitter ⚠
- p.Ser113Ala Single submitter ⚠
- p.Ser376Pro Single submitter
- p.Ser415Phe Single submitter ⚠
- p.Ser441Thr Single submitter ⚠
- p.Thr266Ala Single submitter ⚠
- p.Thr76Ile Single submitter ⚠
- p.Tyr393His Single submitter ⚠
- p.Val299Ile Single submitter ⚠