DENND4B — 206 ClinVar variants
All ClinVar germline DENND4B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 175 flagged for review →
1 Likely pathogenic · 1 Conflicting · 6 Benign · 24 Likely benign · 174 Uncertain significance
Full DENND4B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 175
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 97
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
DENND4B p.Val103Ile
Uncertain significance
Multiple submitters
DENND4B-related disorder
- DENND4B p.Ala1113Val Uncertain significance Single submitter
- DENND4B p.Ala332Thr Uncertain significance Single submitter
- DENND4B p.Ala467Ser Uncertain significance Single submitter
- DENND4B p.Ala56Ser Uncertain significance Single submitter
- DENND4B p.Ala753Ser Uncertain significance Single submitter
- DENND4B p.Ala984Thr Uncertain significance Single submitter
- DENND4B p.Arg1046Gln Uncertain significance Single submitter
- DENND4B p.Arg1132His Uncertain significance Single submitter
- DENND4B p.Arg1137Cys Uncertain significance Single submitter
- DENND4B p.Arg149Trp Uncertain significance Single submitter
- DENND4B p.Arg303Gln Uncertain significance Single submitter
- DENND4B p.Arg313His Uncertain significance Single submitter
- DENND4B p.Arg347His Uncertain significance Single submitter
- DENND4B p.Arg39Cys Uncertain significance Single submitter
- DENND4B p.Arg429Gln Uncertain significance Single submitter
- DENND4B p.Arg429Trp Uncertain significance Single submitter
- DENND4B p.Arg42Gln Uncertain significance Single submitter
- DENND4B p.Arg511Gln Uncertain significance Single submitter
- DENND4B p.Arg572His Uncertain significance Single submitter
- DENND4B p.Arg614Cys Uncertain significance Single submitter
- DENND4B p.Arg642Cys Uncertain significance Single submitter
- DENND4B p.Arg710Gln Uncertain significance Single submitter
- DENND4B p.Arg731Cys Uncertain significance Single submitter
- DENND4B p.Arg731His Uncertain significance Single submitter
- DENND4B p.Arg871His Uncertain significance Single submitter
- DENND4B p.Arg871Leu Uncertain significance Single submitter
- DENND4B p.Arg888His Uncertain significance Single submitter
- DENND4B p.Arg94Cys Uncertain significance Single submitter
- DENND4B p.Arg957Gly Uncertain significance Single submitter
- DENND4B p.Arg97His Uncertain significance Single submitter
- DENND4B p.Asn380Ser Uncertain significance Single submitter
- DENND4B p.Asp1004Glu Uncertain significance Single submitter
- DENND4B p.Asp1140Val Uncertain significance Single submitter
- DENND4B p.Asp1452Tyr Uncertain significance Single submitter
- DENND4B p.Asp999Asn Uncertain significance Single submitter
- DENND4B p.Cys180Gly Uncertain significance Single submitter
- DENND4B p.Gln1146His Uncertain significance Single submitter
- DENND4B p.Gln1332Glu Uncertain significance Single submitter
- DENND4B p.Gln534Arg Uncertain significance Single submitter
- DENND4B p.Gln63Pro Uncertain significance Single submitter
- DENND4B p.Gln886Arg Uncertain significance Single submitter
- DENND4B p.Gln971Lys Uncertain significance Single submitter
- DENND4B p.Glu1281Asp Uncertain significance Single submitter
- DENND4B p.Glu152Asp Uncertain significance Single submitter
- DENND4B p.Glu173Lys Uncertain significance Single submitter
- DENND4B p.Glu540Val Uncertain significance Single submitter
- DENND4B p.Glu78Val Uncertain significance Single submitter
- DENND4B p.Gly1016Asp Uncertain significance Single submitter
- DENND4B p.Gly1040Glu Uncertain significance Single submitter
- DENND4B p.Gly1058Ser Uncertain significance Single submitter
- DENND4B p.Gly1216Val Uncertain significance Single submitter
- DENND4B p.Gly1262Glu Uncertain significance Single submitter
- DENND4B p.Gly22Arg Uncertain significance Single submitter
- DENND4B p.Gly309Asp Uncertain significance Single submitter
- DENND4B p.Gly58Ala Uncertain significance Single submitter
- DENND4B p.Gly58Asp Uncertain significance Single submitter
- DENND4B p.Gly956Arg Uncertain significance Single submitter
- DENND4B p.Gly977Ser Uncertain significance Single submitter
- DENND4B p.His426Tyr Uncertain significance Single submitter
- DENND4B p.Ile454Val Uncertain significance Single submitter
- DENND4B p.Ile844Thr Uncertain significance Single submitter
- DENND4B p.Leu1081Arg Uncertain significance Single submitter
- DENND4B p.Leu186Phe Uncertain significance Single submitter
- DENND4B p.Leu432Pro Uncertain significance Single submitter
- DENND4B p.Leu859Trp Uncertain significance Single submitter
- DENND4B p.Met1094Thr Uncertain significance Single submitter
- DENND4B p.Pro1012Leu Uncertain significance Single submitter
- DENND4B p.Pro1012Thr Uncertain significance Single submitter
- DENND4B p.Pro1078Leu Uncertain significance Single submitter
- DENND4B p.Pro1078Thr Uncertain significance Single submitter
- DENND4B p.Pro1381Ser Uncertain significance Single submitter
- DENND4B p.Pro256Thr Uncertain significance Single submitter
- DENND4B p.Pro349Ser Uncertain significance Single submitter
- DENND4B p.Pro665Leu Uncertain significance Single submitter
- DENND4B p.Pro689Leu Uncertain significance Single submitter
- DENND4B p.Pro729Ser Uncertain significance Single submitter
- DENND4B p.Pro933Ser Uncertain significance Single submitter
- DENND4B p.Pro955Ala Uncertain significance Single submitter
- DENND4B p.Ser1096Gly Uncertain significance Single submitter
- DENND4B p.Ser1329Leu Uncertain significance Single submitter
- DENND4B p.Thr1052Ser Uncertain significance Single submitter
- DENND4B p.Thr124Arg Uncertain significance Single submitter
- DENND4B p.Thr125Ala Uncertain significance Single submitter
- DENND4B p.Thr178Ala Uncertain significance Single submitter
- DENND4B p.Thr251Ala Uncertain significance Single submitter
- DENND4B p.Thr666Ala Uncertain significance Single submitter
- DENND4B p.Thr942Ala Uncertain significance Single submitter
- DENND4B p.Thr973Asn Uncertain significance Single submitter
- DENND4B p.Tyr620Cys Uncertain significance Single submitter
- DENND4B p.Val10Ala Uncertain significance Single submitter
- DENND4B p.Val1353Ile Uncertain significance Single submitter
- DENND4B p.Val1366Ala Uncertain significance Single submitter
- DENND4B p.Val14Met Uncertain significance Single submitter
- DENND4B p.Val233Met Uncertain significance Single submitter
- DENND4B p.Val257Ile Uncertain significance Single submitter
- DENND4B p.Val90Ile Uncertain significance Single submitter
Predictors split 78
The independent predictors disagree with each other — read with care.
- DENND4B p.Arg561Trp Uncertain significance Multiple submitters
- DENND4B p.Ala1089Val Uncertain significance Single submitter
- DENND4B p.Ala1408Val Uncertain significance Single submitter
- DENND4B p.Ala150Thr Uncertain significance Single submitter
-
DENND4B p.Ala16Thr
Uncertain significance
Single submitter
DENND4B-related disorder
- DENND4B p.Ala275Thr Uncertain significance Single submitter
- DENND4B p.Ala596Val Uncertain significance Single submitter
- DENND4B p.Ala944Asp Uncertain significance Single submitter
- DENND4B p.Arg1039Trp Uncertain significance Single submitter
- DENND4B p.Arg1069Cys Uncertain significance Single submitter
- DENND4B p.Arg1069His Uncertain significance Single submitter
- DENND4B p.Arg1090Cys Uncertain significance Single submitter
- DENND4B p.Arg1090His Uncertain significance Single submitter
- DENND4B p.Arg1101Trp Uncertain significance Single submitter
- DENND4B p.Arg1103His Uncertain significance Single submitter
- DENND4B p.Arg114Cys Uncertain significance Single submitter
- DENND4B p.Arg1206Gln Uncertain significance Single submitter
- DENND4B p.Arg1273His Uncertain significance Single submitter
- DENND4B p.Arg1312Cys Uncertain significance Single submitter
- DENND4B p.Arg142Cys Uncertain significance Single submitter
- DENND4B p.Arg142His Uncertain significance Single submitter
- DENND4B p.Arg184His Uncertain significance Single submitter
- DENND4B p.Arg331Cys Uncertain significance Single submitter
- DENND4B p.Arg42Trp Uncertain significance Single submitter
- DENND4B p.Arg515Cys Uncertain significance Single submitter
- DENND4B p.Arg558His Uncertain significance Single submitter
- DENND4B p.Arg801Cys Uncertain significance Single submitter
- DENND4B p.Arg840His Uncertain significance Single submitter
- DENND4B p.Arg871Cys Uncertain significance Single submitter
- DENND4B p.Arg873His Uncertain significance Single submitter
- DENND4B p.Arg8Trp Uncertain significance Single submitter
- DENND4B p.Arg930His Uncertain significance Single submitter
- DENND4B p.Arg939His Uncertain significance Single submitter
- DENND4B p.Arg94His Uncertain significance Single submitter
- DENND4B p.Arg95Lys Uncertain significance Single submitter
- DENND4B p.Asp1004Ala Uncertain significance Single submitter
- DENND4B p.Asp1084Asn Uncertain significance Single submitter
- DENND4B p.Asp1179Val Uncertain significance Single submitter
- DENND4B p.Asp1447Ala Uncertain significance Single submitter
- DENND4B p.Gln902Glu Uncertain significance Single submitter
- DENND4B p.Gln907Glu Uncertain significance Single submitter
- DENND4B p.Glu1110Lys Uncertain significance Single submitter
- DENND4B p.Glu1283Lys Uncertain significance Single submitter
- DENND4B p.Glu27Lys Uncertain significance Single submitter
- DENND4B p.Glu302Val Uncertain significance Single submitter
- DENND4B p.Gly1056Trp Uncertain significance Single submitter
- DENND4B p.Gly111Glu Uncertain significance Single submitter
- DENND4B p.Gly296Ser Uncertain significance Single submitter
- DENND4B p.Ile844Met Uncertain significance Single submitter
- DENND4B p.Leu1002Phe Uncertain significance Single submitter
- DENND4B p.Leu1097Ile Uncertain significance Single submitter
- DENND4B p.Leu1129Gln Uncertain significance Single submitter
- DENND4B p.Leu1129Val Uncertain significance Single submitter
- DENND4B p.Leu1267Val Uncertain significance Single submitter
- DENND4B p.Leu1322Pro Uncertain significance Single submitter
-
DENND4B p.Leu440Val
Uncertain significance
Single submitter
DENND4B-related disorder
- DENND4B p.Lys747Glu Uncertain significance Single submitter
- DENND4B p.Met981Ile Uncertain significance Single submitter
- DENND4B p.Phe1435Leu Uncertain significance Single submitter
- DENND4B p.Pro1148Arg Uncertain significance Single submitter
- DENND4B p.Pro328Leu Uncertain significance Single submitter
- DENND4B p.Pro658Thr Uncertain significance Single submitter
- DENND4B p.Ser1109Pro Uncertain significance Single submitter
- DENND4B p.Ser1156Thr Uncertain significance Single submitter
- DENND4B p.Ser1315Asn Uncertain significance Single submitter
- DENND4B p.Ser314Asn Uncertain significance Single submitter
- DENND4B p.Ser544Cys Uncertain significance Single submitter
- DENND4B p.Ser616Gly Uncertain significance Single submitter
- DENND4B p.Ser630Pro Uncertain significance Single submitter
- DENND4B p.Ser922Phe Uncertain significance Single submitter
- DENND4B p.Thr124Met Uncertain significance Single submitter
- DENND4B p.Thr208Met Uncertain significance Single submitter
- DENND4B p.Thr29Met Uncertain significance Single submitter
- DENND4B p.Thr419Ala Uncertain significance Single submitter
- DENND4B p.Thr934Ile Uncertain significance Single submitter
-
DENND4B p.Leu609Phe
Likely pathogenic
No assertion criteria
Short stature
-
DENND4B p.Trp943Ser
Conflicting
No assertion criteria
Short stature
-
DENND4B p.Val121Met
Uncertain significance
No assertion criteria
DENND4B-related disorder
All DENND4B variants
Likely pathogenic 1
- p.Leu609Phe No assertion criteria Short stature ⚠
Conflicting classifications of pathogenicity 1
- p.Trp943Ser No assertion criteria Short stature ⚠
Benign 6
- c.-6G>C No assertion criteria DENND4B-related disorder
- p.Ala281= No assertion criteria DENND4B-related disorder
- p.Gln901= No assertion criteria DENND4B-related disorder
- p.Gly36= No assertion criteria DENND4B-related disorder
- p.Thr1437= No assertion criteria DENND4B-related disorder
- p.Tyr701= No assertion criteria DENND4B-related disorder
Likely benign 24
- p.Ala439= Single submitter
- p.Gln902fs Single submitter
- p.Gln908_Gln910del Single submitter
- p.Ser1208= Single submitter
- p.Tyr127= Single submitter
- p.Val10= Single submitter
- c.1056-3del No assertion criteria DENND4B-related disorder
- c.1819+4T>C No assertion criteria DENND4B-related disorder
- c.2439+10C>T No assertion criteria DENND4B-related disorder
- c.3624-6C>T No assertion criteria DENND4B-related disorder
- c.4115-3C>T No assertion criteria DENND4B-related disorder
- p.Ala1458= No assertion criteria DENND4B-related disorder
- p.Arg316= No assertion criteria DENND4B-related disorder
- p.Gln902_Gln910del No assertion criteria DENND4B-related disorder
- p.Gln910_Glu911insGln No assertion criteria DENND4B-related disorder
- p.Glu635= No assertion criteria DENND4B-related disorder
- p.His1473= No assertion criteria DENND4B-related disorder
- p.Leu1305= No assertion criteria DENND4B-related disorder
- p.Phe13= No assertion criteria DENND4B-related disorder
- p.Pro1012= No assertion criteria DENND4B-related disorder
- p.Pro230= No assertion criteria DENND4B-related disorder
- p.Ser299= No assertion criteria DENND4B-related disorder
- p.Val235Ile No assertion criteria DENND4B-related disorder
- p.Val555= No assertion criteria DENND4B-related disorder
Uncertain significance 174
- p.Arg561Trp Multiple submitters ⚠
- p.Val103Ile Multiple submitters DENND4B-related disorder ⚠
- p.Ala1089Val Single submitter ⚠
- p.Ala1113Val Single submitter ⚠
- p.Ala1408Val Single submitter ⚠
- p.Ala150Thr Single submitter ⚠
- p.Ala16Thr Single submitter DENND4B-related disorder ⚠
- p.Ala275Thr Single submitter ⚠
- p.Ala332Thr Single submitter ⚠
- p.Ala467Ser Single submitter ⚠
- p.Ala56Ser Single submitter ⚠
- p.Ala596Val Single submitter ⚠
- p.Ala753Ser Single submitter ⚠
- p.Ala944Asp Single submitter ⚠
- p.Ala984Thr Single submitter ⚠
- p.Arg1039Trp Single submitter ⚠
- p.Arg1046Gln Single submitter ⚠
- p.Arg1069Cys Single submitter ⚠
- p.Arg1069His Single submitter ⚠
- p.Arg1090Cys Single submitter ⚠
- p.Arg1090His Single submitter ⚠
- p.Arg1101Trp Single submitter ⚠
- p.Arg1103His Single submitter ⚠
- p.Arg1132His Single submitter ⚠
- p.Arg1137Cys Single submitter ⚠
- p.Arg114Cys Single submitter ⚠
- p.Arg1206Gln Single submitter ⚠
- p.Arg1273His Single submitter ⚠
- p.Arg1312Cys Single submitter ⚠
- p.Arg142Cys Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg184His Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg313His Single submitter ⚠
- p.Arg331Cys Single submitter ⚠
- p.Arg347His Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg429Gln Single submitter ⚠
- p.Arg429Trp Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg42Trp Single submitter ⚠
- p.Arg511Gln Single submitter ⚠
- p.Arg515Cys Single submitter ⚠
- p.Arg558His Single submitter ⚠
- p.Arg572His Single submitter ⚠
- p.Arg614Cys Single submitter ⚠
- p.Arg642Cys Single submitter ⚠
- p.Arg710Gln Single submitter ⚠
- p.Arg731Cys Single submitter ⚠
- p.Arg731His Single submitter ⚠
- p.Arg801Cys Single submitter ⚠
- p.Arg840His Single submitter ⚠
- p.Arg871Cys Single submitter ⚠
- p.Arg871His Single submitter ⚠
- p.Arg871Leu Single submitter ⚠
- p.Arg873His Single submitter ⚠
- p.Arg888His Single submitter ⚠
- p.Arg8Trp Single submitter ⚠
- p.Arg930His Single submitter ⚠
- p.Arg939His Single submitter ⚠
- p.Arg94Cys Single submitter ⚠
- p.Arg94His Single submitter ⚠
- p.Arg957Gly Single submitter ⚠
- p.Arg95Lys Single submitter ⚠
- p.Arg97His Single submitter ⚠
- p.Asn380Ser Single submitter ⚠
- p.Asp1004Ala Single submitter ⚠
- p.Asp1004Glu Single submitter ⚠
- p.Asp1084Asn Single submitter ⚠
- p.Asp1140Val Single submitter ⚠
- p.Asp1179Val Single submitter ⚠
- p.Asp1447Ala Single submitter ⚠
- p.Asp1452Tyr Single submitter ⚠
- p.Asp999Asn Single submitter ⚠
- p.Cys180Gly Single submitter ⚠
- p.Gln1146His Single submitter ⚠
- p.Gln1332Glu Single submitter ⚠
- p.Gln534Arg Single submitter ⚠
- p.Gln63Pro Single submitter ⚠
- p.Gln886Arg Single submitter ⚠
- p.Gln902Glu Single submitter ⚠
- p.Gln907Glu Single submitter ⚠
- p.Gln971Lys Single submitter ⚠
- p.Glu1110Lys Single submitter ⚠
- p.Glu1281Asp Single submitter ⚠
- p.Glu1283Lys Single submitter ⚠
- p.Glu152Asp Single submitter ⚠
- p.Glu173Lys Single submitter ⚠
- p.Glu27Lys Single submitter ⚠
- p.Glu302Val Single submitter ⚠
- p.Glu540Val Single submitter ⚠
- p.Glu78Val Single submitter ⚠
- p.Gly1016Asp Single submitter ⚠
- p.Gly1040Glu Single submitter ⚠
- p.Gly1056Trp Single submitter ⚠
- p.Gly1058Ser Single submitter ⚠
- p.Gly111Glu Single submitter ⚠
- p.Gly1216Val Single submitter ⚠
- p.Gly1262Glu Single submitter ⚠
- p.Gly22Arg Single submitter ⚠
- p.Gly296Ser Single submitter ⚠
- p.Gly309Asp Single submitter ⚠
- p.Gly58Ala Single submitter ⚠
- p.Gly58Asp Single submitter ⚠
- p.Gly956Arg Single submitter ⚠
- p.Gly977Ser Single submitter ⚠
- p.His426Tyr Single submitter ⚠
- p.Ile454Val Single submitter ⚠
- p.Ile844Met Single submitter ⚠
- p.Ile844Thr Single submitter ⚠
- p.Leu1002Phe Single submitter ⚠
- p.Leu1081Arg Single submitter ⚠
- p.Leu1097Ile Single submitter ⚠
- p.Leu1129Gln Single submitter ⚠
- p.Leu1129Val Single submitter ⚠
- p.Leu1267Val Single submitter ⚠
- p.Leu1322Pro Single submitter ⚠
- p.Leu186Phe Single submitter ⚠
- p.Leu432Pro Single submitter ⚠
- p.Leu440Val Single submitter DENND4B-related disorder ⚠
- p.Leu859Trp Single submitter ⚠
- p.Lys747Glu Single submitter ⚠
- p.Met1094Thr Single submitter ⚠
- p.Met981Ile Single submitter ⚠
- p.Phe1435Leu Single submitter ⚠
- p.Pro1012Leu Single submitter ⚠
- p.Pro1012Thr Single submitter ⚠
- p.Pro1078Leu Single submitter ⚠
- p.Pro1078Thr Single submitter ⚠
- p.Pro1148Arg Single submitter ⚠
- p.Pro1381Ser Single submitter ⚠
- p.Pro256Thr Single submitter ⚠
- p.Pro328Leu Single submitter ⚠
- p.Pro349Ser Single submitter ⚠
- p.Pro658Thr Single submitter ⚠
- p.Pro665Leu Single submitter ⚠
- p.Pro689Leu Single submitter ⚠
- p.Pro729Ser Single submitter ⚠
- p.Pro933Ser Single submitter ⚠
- p.Pro955Ala Single submitter ⚠
- p.Ser1096Gly Single submitter ⚠
- p.Ser1109Pro Single submitter ⚠
- p.Ser1156Thr Single submitter ⚠
- p.Ser1315Asn Single submitter ⚠
- p.Ser1329Leu Single submitter ⚠
- p.Ser314Asn Single submitter ⚠
- p.Ser544Cys Single submitter ⚠
- p.Ser616Gly Single submitter ⚠
- p.Ser630Pro Single submitter ⚠
- p.Ser922Phe Single submitter ⚠
- p.Thr1052Ser Single submitter ⚠
- p.Thr124Arg Single submitter ⚠
- p.Thr124Met Single submitter ⚠
- p.Thr125Ala Single submitter ⚠
- p.Thr178Ala Single submitter ⚠
- p.Thr208Met Single submitter ⚠
- p.Thr251Ala Single submitter ⚠
- p.Thr29Met Single submitter ⚠
- p.Thr419Ala Single submitter ⚠
- p.Thr666Ala Single submitter ⚠
- p.Thr934Ile Single submitter ⚠
- p.Thr942Ala Single submitter ⚠
- p.Thr973Asn Single submitter ⚠
- p.Tyr620Cys Single submitter ⚠
- p.Val10Ala Single submitter ⚠
- p.Val1353Ile Single submitter ⚠
- p.Val1366Ala Single submitter ⚠
- p.Val14Met Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val257Ile Single submitter ⚠
- p.Val90Ile Single submitter ⚠
- p.Gln910_Glu911insGlnGlnGlnGlnGlnGlnGln No assertion criteria DENND4B-related disorder
- p.Val121Met No assertion criteria DENND4B-related disorder ⚠