DENND6A — 47 ClinVar variants
All ClinVar germline DENND6A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 45 Uncertain significance
Full DENND6A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND6A p.Ala35Ser Uncertain significance Single submitter
- DENND6A p.Arg27Ser Uncertain significance Single submitter
- DENND6A p.Arg370Leu Uncertain significance Single submitter
- DENND6A p.Arg521Gln Uncertain significance Single submitter
- DENND6A p.Asp500Asn Uncertain significance Single submitter
- DENND6A p.Asp56Asn Uncertain significance Single submitter
- DENND6A p.Asp588Asn Uncertain significance Single submitter
- DENND6A p.Cys274Phe Uncertain significance Single submitter
- DENND6A p.Gln250His Uncertain significance Single submitter
- DENND6A p.Gly10Arg Uncertain significance Single submitter
- DENND6A p.Gly516Val Uncertain significance Single submitter
- DENND6A p.His586Tyr Uncertain significance Single submitter
- DENND6A p.Ile350Thr Uncertain significance Single submitter
- DENND6A p.Ile416Val Uncertain significance Single submitter
- DENND6A p.Ile435Thr Uncertain significance Single submitter
- DENND6A p.Ile448Val Uncertain significance Single submitter
- DENND6A p.Leu537Ile Uncertain significance Single submitter
- DENND6A p.Leu99Phe Uncertain significance Single submitter
- DENND6A p.Lys137Arg Uncertain significance Single submitter
- DENND6A p.Phe357Val Uncertain significance Single submitter
- DENND6A p.Phe70Leu Uncertain significance Single submitter
- DENND6A p.Pro11Leu Uncertain significance Single submitter
- DENND6A p.Pro450Leu Uncertain significance Single submitter
- DENND6A p.Ser100Ala Uncertain significance Single submitter
- DENND6A p.Ser282Cys Uncertain significance Single submitter
- DENND6A p.Val126Leu Uncertain significance Single submitter
- DENND6A p.Val141Leu Uncertain significance Single submitter
- DENND6A p.Val231Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- DENND6A p.Ala207Val Uncertain significance Single submitter
- DENND6A p.Ala35Val Uncertain significance Single submitter
- DENND6A p.Arg235Trp Uncertain significance Single submitter
- DENND6A p.Arg506Trp Uncertain significance Single submitter
- DENND6A p.Asn391Lys Uncertain significance Single submitter
- DENND6A p.Asp373Asn Uncertain significance Single submitter
- DENND6A p.Glu44Lys Uncertain significance Single submitter
- DENND6A p.Leu3Phe Uncertain significance Single submitter
- DENND6A p.Leu443Val Uncertain significance Single submitter
- DENND6A p.Leu534Val Uncertain significance Single submitter
- DENND6A p.Leu543Phe Uncertain significance Single submitter
- DENND6A p.Lys233Met Uncertain significance Single submitter
- DENND6A p.Pro202Ser Uncertain significance Single submitter
- DENND6A p.Pro264Arg Uncertain significance Single submitter
- DENND6A p.Pro300Ala Uncertain significance Single submitter
- DENND6A p.Thr605Met Uncertain significance Single submitter
- DENND6A p.Val65Met Uncertain significance Single submitter
All DENND6A variants
Likely benign 2
- p.Leu62= Single submitter
- p.Thr377Ala Single submitter
Uncertain significance 45
- p.Ala207Val Single submitter ⚠
- p.Ala35Ser Single submitter ⚠
- p.Ala35Val Single submitter ⚠
- p.Arg235Trp Single submitter ⚠
- p.Arg27Ser Single submitter ⚠
- p.Arg370Leu Single submitter ⚠
- p.Arg506Trp Single submitter ⚠
- p.Arg521Gln Single submitter ⚠
- p.Asn391Lys Single submitter ⚠
- p.Asp373Asn Single submitter ⚠
- p.Asp500Asn Single submitter ⚠
- p.Asp56Asn Single submitter ⚠
- p.Asp588Asn Single submitter ⚠
- p.Cys274Phe Single submitter ⚠
- p.Gln250His Single submitter ⚠
- p.Glu44Lys Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly516Val Single submitter ⚠
- p.His586Tyr Single submitter ⚠
- p.Ile350Thr Single submitter ⚠
- p.Ile416Val Single submitter ⚠
- p.Ile435Thr Single submitter ⚠
- p.Ile448Val Single submitter ⚠
- p.Leu3Phe Single submitter ⚠
- p.Leu443Val Single submitter ⚠
- p.Leu534Val Single submitter ⚠
- p.Leu537Ile Single submitter ⚠
- p.Leu543Phe Single submitter ⚠
- p.Leu99Phe Single submitter ⚠
- p.Lys137Arg Single submitter ⚠
- p.Lys233Met Single submitter ⚠
- p.Phe357Val Single submitter ⚠
- p.Phe70Leu Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro202Ser Single submitter ⚠
- p.Pro264Arg Single submitter ⚠
- p.Pro300Ala Single submitter ⚠
- p.Pro450Leu Single submitter ⚠
- p.Ser100Ala Single submitter ⚠
- p.Ser282Cys Single submitter ⚠
- p.Thr605Met Single submitter ⚠
- p.Val126Leu Single submitter ⚠
- p.Val141Leu Single submitter ⚠
- p.Val231Ile Single submitter ⚠
- p.Val65Met Single submitter ⚠