DENND6B — 104 ClinVar variants
All ClinVar germline DENND6B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
2 Likely benign · 102 Uncertain significance
Full DENND6B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 77
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENND6B p.Ala181Glu Uncertain significance Single submitter
- DENND6B p.Ala196Val Uncertain significance Single submitter
- DENND6B p.Ala19Pro Uncertain significance Single submitter
- DENND6B p.Ala384Thr Uncertain significance Single submitter
- DENND6B p.Ala394Val Uncertain significance Single submitter
- DENND6B p.Ala3Pro Uncertain significance Single submitter
- DENND6B p.Ala506Thr Uncertain significance Single submitter
- DENND6B p.Ala563Thr Uncertain significance Single submitter
- DENND6B p.Arg11Gln Uncertain significance Single submitter
- DENND6B p.Arg158Cys Uncertain significance Single submitter
- DENND6B p.Arg256Trp Uncertain significance Single submitter
- DENND6B p.Arg306Cys Uncertain significance Single submitter
- DENND6B p.Arg306His Uncertain significance Single submitter
- DENND6B p.Arg371Lys Uncertain significance Single submitter
- DENND6B p.Arg391His Uncertain significance Single submitter
- DENND6B p.Arg464Cys Uncertain significance Single submitter
- DENND6B p.Arg464His Uncertain significance Single submitter
- DENND6B p.Arg501Gln Uncertain significance Single submitter
- DENND6B p.Arg547Gln Uncertain significance Single submitter
- DENND6B p.Arg547Pro Uncertain significance Single submitter
- DENND6B p.Arg67Gln Uncertain significance Single submitter
- DENND6B p.Asp111Asn Uncertain significance Single submitter
- DENND6B p.Asp178Glu Uncertain significance Single submitter
- DENND6B p.Asp192His Uncertain significance Single submitter
- DENND6B p.Asp283Asn Uncertain significance Single submitter
- DENND6B p.Asp410Asn Uncertain significance Single submitter
- DENND6B p.Asp410Gly Uncertain significance Single submitter
- DENND6B p.Gln150His Uncertain significance Single submitter
- DENND6B p.Gln453Glu Uncertain significance Single submitter
- DENND6B p.Gln453Lys Uncertain significance Single submitter
- DENND6B p.Gln459Pro Uncertain significance Single submitter
- DENND6B p.Gln472Arg Uncertain significance Single submitter
- DENND6B p.Gln564Lys Uncertain significance Single submitter
- DENND6B p.Glu224Lys Uncertain significance Single submitter
- DENND6B p.Glu523Lys Uncertain significance Single submitter
- DENND6B p.Glu533Lys Uncertain significance Single submitter
- DENND6B p.Gly132Ser Uncertain significance Single submitter
- DENND6B p.Gly25Arg Uncertain significance Single submitter
- DENND6B p.Gly358Glu Uncertain significance Single submitter
- DENND6B p.Gly572Ser Uncertain significance Single submitter
- DENND6B p.His502Tyr Uncertain significance Single submitter
- DENND6B p.Ile172Val Uncertain significance Single submitter
- DENND6B p.Ile191Val Uncertain significance Single submitter
- DENND6B p.Ile428Val Uncertain significance Single submitter
- DENND6B p.Ile445Val Uncertain significance Single submitter
- DENND6B p.Leu290Pro Uncertain significance Single submitter
- DENND6B p.Leu5Ser Uncertain significance Single submitter
- DENND6B p.Lys503Arg Uncertain significance Single submitter
- DENND6B p.Lys71Glu Uncertain significance Single submitter
- DENND6B p.Phe131Leu Uncertain significance Single submitter
- DENND6B p.Pro174His Uncertain significance Single submitter
- DENND6B p.Pro197Leu Uncertain significance Single submitter
- DENND6B p.Pro21Leu Uncertain significance Single submitter
- DENND6B p.Pro227Ser Uncertain significance Single submitter
- DENND6B p.Pro228Leu Uncertain significance Single submitter
- DENND6B p.Pro228Ser Uncertain significance Single submitter
- DENND6B p.Pro31Ser Uncertain significance Single submitter
- DENND6B p.Pro369Ser Uncertain significance Single submitter
- DENND6B p.Pro554Leu Uncertain significance Single submitter
- DENND6B p.Pro63Leu Uncertain significance Single submitter
- DENND6B p.Ser170Asn Uncertain significance Single submitter
- DENND6B p.Ser189Asn Uncertain significance Single submitter
- DENND6B p.Ser286Leu Uncertain significance Single submitter
- DENND6B p.Ser294Gly Uncertain significance Single submitter
- DENND6B p.Ser465Thr Uncertain significance Single submitter
- DENND6B p.Thr310Ser Uncertain significance Single submitter
- DENND6B p.Thr377Asn Uncertain significance Single submitter
- DENND6B p.Thr386Met Uncertain significance Single submitter
- DENND6B p.Thr559Ala Uncertain significance Single submitter
- DENND6B p.Tyr130Cys Uncertain significance Single submitter
- DENND6B p.Val121Gly Uncertain significance Single submitter
- DENND6B p.Val134Met Uncertain significance Single submitter
- DENND6B p.Val154Met Uncertain significance Single submitter
- DENND6B p.Val187Ala Uncertain significance Single submitter
- DENND6B p.Val210Ile Uncertain significance Single submitter
- DENND6B p.Val241Leu Uncertain significance Single submitter
- DENND6B p.Val284Met Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- DENND6B p.Ala511Thr Uncertain significance Single submitter
- DENND6B p.Ala580Pro Uncertain significance Single submitter
- DENND6B p.Arg37Cys Uncertain significance Single submitter
- DENND6B p.Arg407Trp Uncertain significance Single submitter
- DENND6B p.Arg417Gln Uncertain significance Single submitter
- DENND6B p.Arg417Leu Uncertain significance Single submitter
- DENND6B p.Arg417Trp Uncertain significance Single submitter
- DENND6B p.Arg499Trp Uncertain significance Single submitter
- DENND6B p.Arg542Cys Uncertain significance Single submitter
- DENND6B p.Arg542His Uncertain significance Single submitter
- DENND6B p.Asp461Val Uncertain significance Single submitter
- DENND6B p.Cys518Ser Uncertain significance Single submitter
- DENND6B p.Glu531Lys Uncertain significance Single submitter
- DENND6B p.His261Asn Uncertain significance Single submitter
- DENND6B p.Leu54Gln Uncertain significance Single submitter
- DENND6B p.Pro195Leu Uncertain significance Single submitter
- DENND6B p.Pro199Ser Uncertain significance Single submitter
- DENND6B p.Pro217Ser Uncertain significance Single submitter
- DENND6B p.Pro408Gln Uncertain significance Single submitter
- DENND6B p.Pro452Leu Uncertain significance Single submitter
- DENND6B p.Thr323Met Uncertain significance Single submitter
- DENND6B p.Val329Met Uncertain significance Single submitter
All DENND6B variants
Likely benign 2
- p.Ala198Val Single submitter
- p.Lys406= Single submitter
Uncertain significance 102
- p.Ala181Glu Single submitter ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala19Pro Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Ala394Val Single submitter ⚠
- p.Ala3Pro Single submitter ⚠
- p.Ala506Thr Single submitter ⚠
- p.Ala511Thr Single submitter ⚠
- p.Ala563Thr Single submitter ⚠
- p.Ala580Pro Single submitter ⚠
- p.Arg11Gln Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg256Trp Single submitter ⚠
- p.Arg306Cys Single submitter ⚠
- p.Arg306His Single submitter ⚠
- p.Arg371Lys Single submitter ⚠
- p.Arg37Cys Single submitter ⚠
- p.Arg391His Single submitter ⚠
- p.Arg407Trp Single submitter ⚠
- p.Arg417Gln Single submitter ⚠
- p.Arg417Leu Single submitter ⚠
- p.Arg417Trp Single submitter ⚠
- p.Arg464Cys Single submitter ⚠
- p.Arg464His Single submitter ⚠
- p.Arg499Trp Single submitter ⚠
- p.Arg501Gln Single submitter ⚠
- p.Arg542Cys Single submitter ⚠
- p.Arg542His Single submitter ⚠
- p.Arg547Gln Single submitter ⚠
- p.Arg547Pro Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Arg97His Single submitter
- p.Asp111Asn Single submitter ⚠
- p.Asp178Glu Single submitter ⚠
- p.Asp192His Single submitter ⚠
- p.Asp283Asn Single submitter ⚠
- p.Asp392Asn Single submitter
- p.Asp410Asn Single submitter ⚠
- p.Asp410Gly Single submitter ⚠
- p.Asp461Val Single submitter ⚠
- p.Cys518Ser Single submitter ⚠
- p.Gln150His Single submitter ⚠
- p.Gln453Glu Single submitter ⚠
- p.Gln453Lys Single submitter ⚠
- p.Gln459Pro Single submitter ⚠
- p.Gln472Arg Single submitter ⚠
- p.Gln564Lys Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Glu523Lys Single submitter ⚠
- p.Glu531Lys Single submitter ⚠
- p.Glu533Lys Single submitter ⚠
- p.Gly132Ser Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly358Glu Single submitter ⚠
- p.Gly572Ser Single submitter ⚠
- p.His261Asn Single submitter ⚠
- p.His502Tyr Single submitter ⚠
- p.Ile172Val Single submitter ⚠
- p.Ile191Val Single submitter ⚠
- p.Ile428Val Single submitter ⚠
- p.Ile445Val Single submitter ⚠
- p.Leu290Pro Single submitter ⚠
- p.Leu54Gln Single submitter ⚠
- p.Leu5Ser Single submitter ⚠
- p.Lys503Arg Single submitter ⚠
- p.Lys71Glu Single submitter ⚠
- p.Phe131Leu Single submitter ⚠
- p.Pro174His Single submitter ⚠
- p.Pro195Leu Single submitter ⚠
- p.Pro197Leu Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro206Ser Single submitter
- p.Pro217Ser Single submitter ⚠
- p.Pro21Leu Single submitter ⚠
- p.Pro227Ser Single submitter ⚠
- p.Pro228Leu Single submitter ⚠
- p.Pro228Ser Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro369Ser Single submitter ⚠
- p.Pro408Gln Single submitter ⚠
- p.Pro452Leu Single submitter ⚠
- p.Pro554Leu Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Ser170Asn Single submitter ⚠
- p.Ser189Asn Single submitter ⚠
- p.Ser286Leu Single submitter ⚠
- p.Ser294Gly Single submitter ⚠
- p.Ser465Thr Single submitter ⚠
- p.Thr310Ser Single submitter ⚠
- p.Thr323Met Single submitter ⚠
- p.Thr377Asn Single submitter ⚠
- p.Thr386Met Single submitter ⚠
- p.Thr559Ala Single submitter ⚠
- p.Tyr130Cys Single submitter ⚠
- p.Val121Gly Single submitter ⚠
- p.Val134Met Single submitter ⚠
- p.Val154Met Single submitter ⚠
- p.Val187Ala Single submitter ⚠
- p.Val210Ile Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val284Met Single submitter ⚠
- p.Val329Met Single submitter ⚠