DENR — 21 ClinVar variants
All ClinVar germline DENR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
7 Likely benign · 14 Uncertain significance
Full DENR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DENR p.Ala21Val Uncertain significance Single submitter
- DENR p.Glu89Asp Uncertain significance Single submitter
- DENR p.Gly194Arg Uncertain significance Single submitter
- DENR p.Ser9Asn Uncertain significance Single submitter
- DENR p.Val111Ile Uncertain significance Single submitter
- DENR p.Val158Ala Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DENR p.Asp186Glu Uncertain significance Single submitter
- DENR p.Asp26Tyr Uncertain significance Single submitter
- DENR p.Gln96Pro Uncertain significance Single submitter
- DENR p.Glu77Ala Uncertain significance Single submitter
- DENR p.Glu89Lys Uncertain significance Single submitter
- DENR p.Leu32Pro Uncertain significance Single submitter
- DENR p.Leu68Phe Uncertain significance Single submitter
- DENR p.Thr116Ile Uncertain significance Single submitter
All DENR variants
Likely benign 7
- c.107-9C>T Single submitter
- p.Pro17Ser Single submitter
- c.295+6A>T No assertion criteria DENR-related disorder
- c.-2A>C No assertion criteria DENR-related disorder
- p.Gly88= No assertion criteria DENR-related disorder
- p.Lys22Thr No assertion criteria DENR-related disorder
- p.Thr110= No assertion criteria DENR-related disorder
Uncertain significance 14
- p.Ala21Val Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Asp26Tyr Single submitter ⚠
- p.Gln96Pro Single submitter ⚠
- p.Glu77Ala Single submitter ⚠
- p.Glu89Asp Single submitter ⚠
- p.Glu89Lys Single submitter ⚠
- p.Gly194Arg Single submitter ⚠
- p.Leu32Pro Single submitter ⚠
- p.Leu68Phe Single submitter ⚠
- p.Ser9Asn Single submitter ⚠
- p.Thr116Ile Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val158Ala Single submitter ⚠