DEPDC1 — 102 ClinVar variants
All ClinVar germline DEPDC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
2 Benign · 3 Likely benign · 97 Uncertain significance
Full DEPDC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEPDC1 p.Ala175Val Uncertain significance Single submitter
- DEPDC1 p.Ala250Val Uncertain significance Single submitter
- DEPDC1 p.Ala280Thr Uncertain significance Single submitter
- DEPDC1 p.Ala377Thr Uncertain significance Single submitter
- DEPDC1 p.Ala658Val Uncertain significance Single submitter
- DEPDC1 p.Ala714Val Uncertain significance Single submitter
- DEPDC1 p.Arg105Ser Uncertain significance Single submitter
- DEPDC1 p.Arg231Cys Uncertain significance Single submitter
- DEPDC1 p.Arg386Ser Uncertain significance Single submitter
- DEPDC1 p.Arg388Ile Uncertain significance Single submitter
- DEPDC1 p.Arg509Gly Uncertain significance Single submitter
- DEPDC1 p.Arg614His Uncertain significance Single submitter
- DEPDC1 p.Arg622Cys Uncertain significance Single submitter
- DEPDC1 p.Arg808Leu Uncertain significance Single submitter
- DEPDC1 p.Asn100Asp Uncertain significance Single submitter
- DEPDC1 p.Asn169Asp Uncertain significance Single submitter
- DEPDC1 p.Asn707Thr Uncertain significance Single submitter
- DEPDC1 p.Asp394Glu Uncertain significance Single submitter
- DEPDC1 p.Asp493Tyr Uncertain significance Single submitter
- DEPDC1 p.Cys502Tyr Uncertain significance Single submitter
- DEPDC1 p.Cys565Arg Uncertain significance Single submitter
- DEPDC1 p.Cys565Ser Uncertain significance Single submitter
- DEPDC1 p.Cys565Tyr Uncertain significance Single submitter
- DEPDC1 p.Gln157Pro Uncertain significance Single submitter
- DEPDC1 p.Gln463Arg Uncertain significance Single submitter
- DEPDC1 p.Gln680Glu Uncertain significance Single submitter
- DEPDC1 p.Gln690Arg Uncertain significance Single submitter
- DEPDC1 p.Glu161Lys Uncertain significance Single submitter
- DEPDC1 p.Glu297Asp Uncertain significance Single submitter
- DEPDC1 p.Glu353Lys Uncertain significance Single submitter
- DEPDC1 p.Gly160Cys Uncertain significance Single submitter
- DEPDC1 p.Gly405Arg Uncertain significance Single submitter
- DEPDC1 p.Gly405Glu Uncertain significance Single submitter
- DEPDC1 p.Gly500Arg Uncertain significance Single submitter
- DEPDC1 p.Gly5Cys Uncertain significance Single submitter
- DEPDC1 p.His154Arg Uncertain significance Single submitter
- DEPDC1 p.His319Arg Uncertain significance Single submitter
- DEPDC1 p.His319Leu Uncertain significance Single submitter
- DEPDC1 p.His593Leu Uncertain significance Single submitter
- DEPDC1 p.Ile367Thr Uncertain significance Single submitter
- DEPDC1 p.Ile426Val Uncertain significance Single submitter
- DEPDC1 p.Ile448Thr Uncertain significance Single submitter
- DEPDC1 p.Ile569Val Uncertain significance Single submitter
- DEPDC1 p.Ile725Val Uncertain significance Single submitter
- DEPDC1 p.Ile801Met Uncertain significance Single submitter
- DEPDC1 p.Leu345Phe Uncertain significance Single submitter
- DEPDC1 p.Leu382Arg Uncertain significance Single submitter
- DEPDC1 p.Leu412Pro Uncertain significance Single submitter
- DEPDC1 p.Leu583Phe Uncertain significance Single submitter
- DEPDC1 p.Leu607Phe Uncertain significance Single submitter
- DEPDC1 p.Leu683Ile Uncertain significance Single submitter
- DEPDC1 p.Leu810Ile Uncertain significance Single submitter
- DEPDC1 p.Lys15Arg Uncertain significance Single submitter
- DEPDC1 p.Lys214Gln Uncertain significance Single submitter
- DEPDC1 p.Lys462Gln Uncertain significance Single submitter
- DEPDC1 p.Lys484Glu Uncertain significance Single submitter
- DEPDC1 p.Lys635Arg Uncertain significance Single submitter
- DEPDC1 p.Lys734Gln Uncertain significance Single submitter
- DEPDC1 p.Lys777Arg Uncertain significance Single submitter
- DEPDC1 p.Lys81Glu Uncertain significance Single submitter
- DEPDC1 p.Lys89Arg Uncertain significance Single submitter
- DEPDC1 p.Met409Thr Uncertain significance Single submitter
- DEPDC1 p.Met534Thr Uncertain significance Single submitter
- DEPDC1 p.Met676Val Uncertain significance Single submitter
- DEPDC1 p.Phe130Ser Uncertain significance Single submitter
- DEPDC1 p.Phe456Val Uncertain significance Single submitter
- DEPDC1 p.Pro29Ala Uncertain significance Single submitter
- DEPDC1 p.Pro578Leu Uncertain significance Single submitter
- DEPDC1 p.Pro772Leu Uncertain significance Single submitter
- DEPDC1 p.Ser156Tyr Uncertain significance Single submitter
- DEPDC1 p.Ser316Thr Uncertain significance Single submitter
- DEPDC1 p.Ser361Tyr Uncertain significance Single submitter
- DEPDC1 p.Ser512Asn Uncertain significance Single submitter
- DEPDC1 p.Ser673Thr Uncertain significance Single submitter
- DEPDC1 p.Ser809Gly Uncertain significance Single submitter
- DEPDC1 p.Thr342Ala Uncertain significance Single submitter
- DEPDC1 p.Thr519Ala Uncertain significance Single submitter
- DEPDC1 p.Tyr282Asn Uncertain significance Single submitter
- DEPDC1 p.Tyr54Cys Uncertain significance Single submitter
- DEPDC1 p.Tyr699Cys Uncertain significance Single submitter
-
DEPDC1 p.Ser487Thr
Uncertain significance
No assertion criteria
Hirschsprung disease
Predictors split 12
The independent predictors disagree with each other — read with care.
- DEPDC1 p.Arg25Gln Uncertain significance Single submitter
- DEPDC1 p.Arg622His Uncertain significance Single submitter
- DEPDC1 p.Asn100Lys Uncertain significance Single submitter
- DEPDC1 p.Asp242Glu Uncertain significance Single submitter
- DEPDC1 p.Asp51Asn Uncertain significance Single submitter
- DEPDC1 p.Met633Ile Uncertain significance Single submitter
- DEPDC1 p.Phe293Ser Uncertain significance Single submitter
- DEPDC1 p.Phe339Val Uncertain significance Single submitter
- DEPDC1 p.Ser736Cys Uncertain significance Single submitter
- DEPDC1 p.Thr45Ile Uncertain significance Single submitter
- DEPDC1 p.Thr642Met Benign Single submitter
- DEPDC1 p.Val693Ala Uncertain significance Single submitter
All DEPDC1 variants
Benign 2
- p.Ter812= Multiple submitters
- p.Thr642Met Single submitter ⚠
Likely benign 3
- p.Arg150Lys Single submitter
- p.Arg231His Single submitter
- p.Pro446Leu Single submitter
Uncertain significance 97
- p.Ala175Val Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala377Thr Single submitter ⚠
- p.Ala46Ser Single submitter
- p.Ala658Val Single submitter ⚠
- p.Ala714Val Single submitter ⚠
- p.Arg105Ser Single submitter ⚠
- p.Arg231Cys Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg386Ser Single submitter ⚠
- p.Arg388Ile Single submitter ⚠
- p.Arg509Gly Single submitter ⚠
- p.Arg614His Single submitter ⚠
- p.Arg622Cys Single submitter ⚠
- p.Arg622His Single submitter ⚠
- p.Arg808Leu Single submitter ⚠
- p.Asn100Asp Single submitter ⚠
- p.Asn100Lys Single submitter ⚠
- p.Asn169Asp Single submitter ⚠
- p.Asn224Ser Single submitter
- p.Asn707Thr Single submitter ⚠
- p.Asp242Glu Single submitter ⚠
- p.Asp394Glu Single submitter ⚠
- p.Asp493Tyr Single submitter ⚠
- p.Asp51Asn Single submitter ⚠
- p.Cys502Tyr Single submitter ⚠
- p.Cys565Arg Single submitter ⚠
- p.Cys565Ser Single submitter ⚠
- p.Cys565Tyr Single submitter ⚠
- p.Cys656Phe Single submitter
- p.Gln157Pro Single submitter ⚠
- p.Gln463Arg Single submitter ⚠
- p.Gln680Glu Single submitter ⚠
- p.Gln690Arg Single submitter ⚠
- p.Glu161Lys Single submitter ⚠
- p.Glu297Asp Single submitter ⚠
- p.Glu353Lys Single submitter ⚠
- p.Glu759Lys Single submitter
- p.Gly160Cys Single submitter ⚠
- p.Gly405Arg Single submitter ⚠
- p.Gly405Glu Single submitter ⚠
- p.Gly500Arg Single submitter ⚠
- p.Gly5Cys Single submitter ⚠
- p.His154Arg Single submitter ⚠
- p.His319Arg Single submitter ⚠
- p.His319Leu Single submitter ⚠
- p.His593Leu Single submitter ⚠
- p.Ile367Thr Single submitter ⚠
- p.Ile426Val Single submitter ⚠
- p.Ile448Thr Single submitter ⚠
- p.Ile569Val Single submitter ⚠
- p.Ile725Val Single submitter ⚠
- p.Ile801Met Single submitter ⚠
- p.Leu345Phe Single submitter ⚠
- p.Leu382Arg Single submitter ⚠
- p.Leu412Pro Single submitter ⚠
- p.Leu583Phe Single submitter ⚠
- p.Leu607Phe Single submitter ⚠
- p.Leu683Ile Single submitter ⚠
- p.Leu810Ile Single submitter ⚠
- p.Lys15Arg Single submitter ⚠
- p.Lys214Gln Single submitter ⚠
- p.Lys462Gln Single submitter ⚠
- p.Lys484Glu Single submitter ⚠
- p.Lys635Arg Single submitter ⚠
- p.Lys734Gln Single submitter ⚠
- p.Lys777Arg Single submitter ⚠
- p.Lys81Glu Single submitter ⚠
- p.Lys89Arg Single submitter ⚠
- p.Met409Thr Single submitter ⚠
- p.Met534Thr Single submitter ⚠
- p.Met633Ile Single submitter ⚠
- p.Met676Val Single submitter ⚠
- p.Phe130Ser Single submitter ⚠
- p.Phe293Ser Single submitter ⚠
- p.Phe339Val Single submitter ⚠
- p.Phe456Val Single submitter ⚠
- p.Pro29Ala Single submitter ⚠
- p.Pro578Leu Single submitter ⚠
- p.Pro772Leu Single submitter ⚠
- p.Ser156Tyr Single submitter ⚠
- p.Ser316Thr Single submitter ⚠
- p.Ser361Tyr Single submitter ⚠
- p.Ser512Asn Single submitter ⚠
- p.Ser673Thr Single submitter ⚠
- p.Ser736Cys Single submitter ⚠
- p.Ser809Gly Single submitter ⚠
- p.Thr342Ala Single submitter ⚠
- p.Thr45Ile Single submitter ⚠
- p.Thr519Ala Single submitter ⚠
- p.Tyr282Asn Single submitter ⚠
- p.Tyr40Cys Single submitter
- p.Tyr54Cys Single submitter ⚠
- p.Tyr699Cys Single submitter ⚠
- p.Val693Ala Single submitter ⚠
- p.Ser487Thr No assertion criteria Hirschsprung disease ⚠