DEPDC1B — 80 ClinVar variants
All ClinVar germline DEPDC1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
2 Likely benign · 78 Uncertain significance
Full DEPDC1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEPDC1B p.Ala180Thr Uncertain significance Single submitter
- DEPDC1B p.Ala453Glu Uncertain significance Single submitter
- DEPDC1B p.Ala454Val Uncertain significance Single submitter
- DEPDC1B p.Arg101His Uncertain significance Single submitter
- DEPDC1B p.Arg158His Uncertain significance Single submitter
- DEPDC1B p.Arg174Cys Uncertain significance Single submitter
- DEPDC1B p.Arg174His Uncertain significance Single submitter
- DEPDC1B p.Arg25Leu Uncertain significance Single submitter
- DEPDC1B p.Arg31Gln Uncertain significance Single submitter
- DEPDC1B p.Arg353Gln Uncertain significance Single submitter
- DEPDC1B p.Arg362His Uncertain significance Single submitter
- DEPDC1B p.Arg406His Uncertain significance Single submitter
- DEPDC1B p.Arg433Cys Uncertain significance Single submitter
- DEPDC1B p.Arg433His Uncertain significance Single submitter
- DEPDC1B p.Arg488Gln Uncertain significance Single submitter
- DEPDC1B p.Arg4Gly Uncertain significance Single submitter
- DEPDC1B p.Asn132His Uncertain significance Single submitter
- DEPDC1B p.Asn132Ser Uncertain significance Single submitter
- DEPDC1B p.Asn142Lys Uncertain significance Single submitter
- DEPDC1B p.Asn255Ser Uncertain significance Single submitter
- DEPDC1B p.Asp234Asn Uncertain significance Single submitter
- DEPDC1B p.Cys347Tyr Uncertain significance Single submitter
- DEPDC1B p.Gln519Leu Uncertain significance Single submitter
- DEPDC1B p.Glu183Asp Uncertain significance Single submitter
- DEPDC1B p.Glu184Gln Uncertain significance Single submitter
- DEPDC1B p.Glu55Ala Uncertain significance Single submitter
- DEPDC1B p.Gly93Ser Uncertain significance Single submitter
- DEPDC1B p.His219Arg Uncertain significance Single submitter
- DEPDC1B p.His3Tyr Uncertain significance Single submitter
- DEPDC1B p.His83Pro Uncertain significance Single submitter
- DEPDC1B p.Ile163Val Uncertain significance Single submitter
- DEPDC1B p.Ile217Val Uncertain significance Single submitter
- DEPDC1B p.Ile424Val Uncertain significance Single submitter
- DEPDC1B p.Ile88Leu Uncertain significance Single submitter
- DEPDC1B p.Leu112Met Uncertain significance Single submitter
- DEPDC1B p.Leu16Arg Uncertain significance Single submitter
- DEPDC1B p.Leu171Phe Uncertain significance Single submitter
- DEPDC1B p.Leu23Val Uncertain significance Single submitter
- DEPDC1B p.Leu456Ser Uncertain significance Single submitter
- DEPDC1B p.Lys127Arg Uncertain significance Single submitter
- DEPDC1B p.Lys196Asn Uncertain significance Single submitter
- DEPDC1B p.Met150Thr Uncertain significance Single submitter
- DEPDC1B p.Met247Val Uncertain significance Single submitter
- DEPDC1B p.Met263Thr Uncertain significance Single submitter
- DEPDC1B p.Met331Thr Uncertain significance Single submitter
- DEPDC1B p.Pro135Leu Uncertain significance Single submitter
- DEPDC1B p.Pro136Arg Uncertain significance Single submitter
- DEPDC1B p.Pro167Ala Uncertain significance Single submitter
- DEPDC1B p.Pro240Ser Uncertain significance Single submitter
- DEPDC1B p.Pro262Ala Uncertain significance Single submitter
- DEPDC1B p.Pro505Leu Uncertain significance Single submitter
- DEPDC1B p.Pro8Arg Uncertain significance Single submitter
- DEPDC1B p.Ser402Ala Uncertain significance Single submitter
- DEPDC1B p.Ser436Gly Uncertain significance Single submitter
- DEPDC1B p.Thr352Ile Uncertain significance Single submitter
- DEPDC1B p.Thr359Ser Uncertain significance Single submitter
- DEPDC1B p.Thr401Asn Uncertain significance Single submitter
- DEPDC1B p.Thr72Met Uncertain significance Single submitter
- DEPDC1B p.Tyr446Cys Uncertain significance Single submitter
- DEPDC1B p.Val309Ala Uncertain significance Single submitter
- DEPDC1B p.Val371Met Uncertain significance Single submitter
- DEPDC1B p.Val67Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DEPDC1B p.Ala308Ser Uncertain significance Single submitter
- DEPDC1B p.Arg15Ser Uncertain significance Single submitter
- DEPDC1B p.Arg324Lys Uncertain significance Single submitter
- DEPDC1B p.Asp234Gly Uncertain significance Single submitter
- DEPDC1B p.Cys169Trp Uncertain significance Single submitter
- DEPDC1B p.Cys363Ser Uncertain significance Single submitter
- DEPDC1B p.Gly266Glu Uncertain significance Single submitter
- DEPDC1B p.His42Pro Uncertain significance Single submitter
- DEPDC1B p.Met28Val Uncertain significance Single submitter
- DEPDC1B p.Pro29Gln Uncertain significance Single submitter
- DEPDC1B p.Val221Gly Uncertain significance Single submitter
All DEPDC1B variants
Likely benign 2
- p.Gly199= Single submitter
- p.His42Arg Single submitter
Uncertain significance 78
- p.Ala180Thr Single submitter ⚠
- p.Ala308Ser Single submitter ⚠
- p.Ala453Glu Single submitter ⚠
- p.Ala454Val Single submitter ⚠
- p.Arg101His Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg15Ser Single submitter ⚠
- p.Arg174Cys Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg25His Single submitter
- p.Arg25Leu Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg324Lys Single submitter ⚠
- p.Arg353Gln Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg406His Single submitter ⚠
- p.Arg433Cys Single submitter ⚠
- p.Arg433His Single submitter ⚠
- p.Arg488Gln Single submitter ⚠
- p.Arg4Gly Single submitter ⚠
- p.Asn132His Single submitter ⚠
- p.Asn132Ser Single submitter ⚠
- p.Asn142Lys Single submitter ⚠
- p.Asn255Ser Single submitter ⚠
- p.Asp234Asn Single submitter ⚠
- p.Asp234Gly Single submitter ⚠
- p.Asp462Val Single submitter
- p.Cys169Trp Single submitter ⚠
- p.Cys347Tyr Single submitter ⚠
- p.Cys363Ser Single submitter ⚠
- p.Gln519Leu Single submitter ⚠
- p.Glu183Asp Single submitter ⚠
- p.Glu184Gln Single submitter ⚠
- p.Glu469Gly Single submitter
- p.Glu55Ala Single submitter ⚠
- p.Gly266Glu Single submitter ⚠
- p.Gly64Ser Single submitter
- p.Gly93Ser Single submitter ⚠
- p.His219Arg Single submitter ⚠
- p.His3Tyr Single submitter ⚠
- p.His42Pro Single submitter ⚠
- p.His54Arg Single submitter
- p.His83Pro Single submitter ⚠
- p.Ile163Val Single submitter ⚠
- p.Ile217Val Single submitter ⚠
- p.Ile424Val Single submitter ⚠
- p.Ile88Leu Single submitter ⚠
- p.Leu112Met Single submitter ⚠
- p.Leu16Arg Single submitter ⚠
- p.Leu171Phe Single submitter ⚠
- p.Leu23Val Single submitter ⚠
- p.Leu456Ser Single submitter ⚠
- p.Lys127Arg Single submitter ⚠
- p.Lys196Asn Single submitter ⚠
- p.Met150Thr Single submitter ⚠
- p.Met247Val Single submitter ⚠
- p.Met263Thr Single submitter ⚠
- p.Met28Val Single submitter ⚠
- p.Met331Thr Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro136Arg Single submitter ⚠
- p.Pro167Ala Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Pro262Ala Single submitter ⚠
- p.Pro29Gln Single submitter ⚠
- p.Pro505Leu Single submitter ⚠
- p.Pro8Arg Single submitter ⚠
- p.Ser402Ala Single submitter ⚠
- p.Ser436Gly Single submitter ⚠
- p.Thr352Ile Single submitter ⚠
- p.Thr359Ser Single submitter ⚠
- p.Thr401Asn Single submitter ⚠
- p.Thr72Met Single submitter ⚠
- p.Tyr446Cys Single submitter ⚠
- p.Val221Gly Single submitter ⚠
- p.Val309Ala Single submitter ⚠
- p.Val371Met Single submitter ⚠
- p.Val67Met Single submitter ⚠