DEPDC4 — 37 ClinVar variants
All ClinVar germline DEPDC4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
3 Likely benign · 34 Uncertain significance
Full DEPDC4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEPDC4 p.Ala13Glu Uncertain significance Single submitter
- DEPDC4 p.Ala13Pro Uncertain significance Single submitter
- DEPDC4 p.Ala196Val Uncertain significance Single submitter
- DEPDC4 p.Ala8Pro Uncertain significance Single submitter
- DEPDC4 p.Asn255Asp Uncertain significance Single submitter
- DEPDC4 p.Asp65Ala Uncertain significance Single submitter
- DEPDC4 p.Gln246Arg Uncertain significance Single submitter
- DEPDC4 p.Glu6Gly Uncertain significance Single submitter
- DEPDC4 p.Gly200Val Uncertain significance Single submitter
- DEPDC4 p.Ile204Thr Uncertain significance Single submitter
- DEPDC4 p.Ile221Met Uncertain significance Single submitter
- DEPDC4 p.Ile67Val Uncertain significance Single submitter
- DEPDC4 p.Leu11His Uncertain significance Single submitter
- DEPDC4 p.Leu285Phe Uncertain significance Single submitter
- DEPDC4 p.Leu29Phe Uncertain significance Single submitter
- DEPDC4 p.Lys119Glu Uncertain significance Single submitter
- DEPDC4 p.Lys140Glu Uncertain significance Single submitter
- DEPDC4 p.Lys270Arg Uncertain significance Single submitter
- DEPDC4 p.Lys49Glu Uncertain significance Single submitter
- DEPDC4 p.Met105Arg Uncertain significance Single submitter
- DEPDC4 p.Met105Thr Uncertain significance Single submitter
- DEPDC4 p.Met138Ile Uncertain significance Single submitter
- DEPDC4 p.Pro226Thr Uncertain significance Single submitter
- DEPDC4 p.Pro37Leu Uncertain significance Single submitter
- DEPDC4 p.Pro3Ser Uncertain significance Single submitter
- DEPDC4 p.Thr17Ile Uncertain significance Single submitter
- DEPDC4 p.Thr222Ala Uncertain significance Single submitter
- DEPDC4 p.Thr52Ala Uncertain significance Single submitter
- DEPDC4 p.Thr92Ala Uncertain significance Single submitter
- DEPDC4 p.Val14Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All DEPDC4 variants
Likely benign 3
- p.Leu34Arg Single submitter
- p.Lys88Glu Single submitter
- p.Thr108Met Single submitter
Uncertain significance 34
- p.Ala13Glu Single submitter ⚠
- p.Ala13Pro Single submitter ⚠
- p.Ala196Val Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Asn255Asp Single submitter ⚠
- p.Asp65Ala Single submitter ⚠
- p.Cys124Phe Single submitter ⚠
- p.Gln125His Single submitter ⚠
- p.Gln246Arg Single submitter ⚠
- p.Glu5Ter Single submitter
- p.Glu6Gly Single submitter ⚠
- p.Gly200Val Single submitter ⚠
- p.Ile204Thr Single submitter ⚠
- p.Ile221Met Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Leu11His Single submitter ⚠
- p.Leu285Phe Single submitter ⚠
- p.Leu29Phe Single submitter ⚠
- p.Lys119Glu Single submitter ⚠
- p.Lys140Glu Single submitter ⚠
- p.Lys270Arg Single submitter ⚠
- p.Lys49Glu Single submitter ⚠
- p.Met105Arg Single submitter ⚠
- p.Met105Thr Single submitter ⚠
- p.Met138Ile Single submitter ⚠
- p.Pro226Thr Single submitter ⚠
- p.Pro37Leu Single submitter ⚠
- p.Pro3Ser Single submitter ⚠
- p.Pro57Thr Single submitter ⚠
- p.Thr17Ile Single submitter ⚠
- p.Thr222Ala Single submitter ⚠
- p.Thr52Ala Single submitter ⚠
- p.Thr92Ala Single submitter ⚠
- p.Val14Ala Single submitter ⚠