DEPDC7 — 64 ClinVar variants
All ClinVar germline DEPDC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
1 Benign · 4 Likely benign · 59 Uncertain significance
Full DEPDC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEPDC7 p.Ala10Ser Uncertain significance Single submitter
- DEPDC7 p.Ala369Gly Uncertain significance Single submitter
- DEPDC7 p.Arg22Gly Uncertain significance Single submitter
- DEPDC7 p.Arg238Gly Uncertain significance Single submitter
- DEPDC7 p.Arg388Lys Uncertain significance Single submitter
- DEPDC7 p.Arg58Cys Uncertain significance Single submitter
- DEPDC7 p.Arg61Gln Uncertain significance Single submitter
- DEPDC7 p.Arg92Gln Uncertain significance Single submitter
- DEPDC7 p.Asn184Ser Uncertain significance Single submitter
- DEPDC7 p.Asp165Gly Uncertain significance Single submitter
- DEPDC7 p.Asp259Tyr Uncertain significance Single submitter
- DEPDC7 p.Asp296His Uncertain significance Single submitter
- DEPDC7 p.Asp511Ala Uncertain significance Single submitter
- DEPDC7 p.Cys452Arg Uncertain significance Single submitter
- DEPDC7 p.Gln204Leu Uncertain significance Single submitter
- DEPDC7 p.Gln438Glu Uncertain significance Single submitter
- DEPDC7 p.Glu176Lys Uncertain significance Single submitter
- DEPDC7 p.Glu300Gly Uncertain significance Single submitter
- DEPDC7 p.Glu481Asp Uncertain significance Single submitter
- DEPDC7 p.Glu6Ala Uncertain significance Single submitter
- DEPDC7 p.Gly252Arg Uncertain significance Single submitter
- DEPDC7 p.Ile199Thr Uncertain significance Single submitter
- DEPDC7 p.Ile80Leu Uncertain significance Single submitter
- DEPDC7 p.Leu102Val Uncertain significance Single submitter
- DEPDC7 p.Leu13Phe Uncertain significance Single submitter
- DEPDC7 p.Leu249Met Uncertain significance Single submitter
- DEPDC7 p.Leu331Ile Uncertain significance Single submitter
- DEPDC7 p.Leu331Val Uncertain significance Single submitter
- DEPDC7 p.Leu493Phe Uncertain significance Single submitter
- DEPDC7 p.Lys120Thr Uncertain significance Single submitter
- DEPDC7 p.Lys484Glu Uncertain significance Single submitter
- DEPDC7 p.Phe108Leu Uncertain significance Single submitter
- DEPDC7 p.Ser185Phe Uncertain significance Single submitter
- DEPDC7 p.Ser27Asn Uncertain significance Single submitter
- DEPDC7 p.Tyr151His Uncertain significance Single submitter
- DEPDC7 p.Tyr156Asn Uncertain significance Single submitter
- DEPDC7 p.Tyr156Cys Uncertain significance Single submitter
- DEPDC7 p.Tyr156His Uncertain significance Single submitter
- DEPDC7 p.Tyr248Cys Uncertain significance Single submitter
- DEPDC7 p.Tyr310His Uncertain significance Single submitter
- DEPDC7 p.Val107Ile Uncertain significance Single submitter
- DEPDC7 p.Val323Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DEPDC7 p.Ala368Thr Uncertain significance Single submitter
- DEPDC7 p.Arg294Pro Uncertain significance Single submitter
- DEPDC7 p.Arg383Gln Uncertain significance Single submitter
- DEPDC7 p.Asp250His Uncertain significance Single submitter
- DEPDC7 p.Glu274Lys Uncertain significance Single submitter
- DEPDC7 p.Leu217Pro Uncertain significance Single submitter
- DEPDC7 p.Lys421Glu Uncertain significance Single submitter
- DEPDC7 p.Pro289Ala Uncertain significance Single submitter
- DEPDC7 p.Ser195Tyr Uncertain significance Single submitter
- DEPDC7 p.Thr36Ala Uncertain significance Single submitter
- DEPDC7 p.Val395Ala Uncertain significance Single submitter
All DEPDC7 variants
Benign 1
- p.Asn444Lys Multiple submitters
Likely benign 4
- p.Arg58His Single submitter
- p.Asn462Ser Single submitter
- p.Gln5Arg Single submitter
- p.Glu283Asp Single submitter
Uncertain significance 59
- p.Ala10Ser Single submitter ⚠
- p.Ala368Thr Single submitter ⚠
- p.Ala369Gly Single submitter ⚠
- p.Arg22Gly Single submitter ⚠
- p.Arg238Gly Single submitter ⚠
- p.Arg294Pro Single submitter ⚠
- p.Arg383Gln Single submitter ⚠
- p.Arg388Lys Single submitter ⚠
- p.Arg58Cys Single submitter ⚠
- p.Arg61Gln Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Asn184Ser Single submitter ⚠
- p.Asp165Gly Single submitter ⚠
- p.Asp250His Single submitter ⚠
- p.Asp259Tyr Single submitter ⚠
- p.Asp296His Single submitter ⚠
- p.Asp511Ala Single submitter ⚠
- p.Cys452Arg Single submitter ⚠
- p.Gln204Leu Single submitter ⚠
- p.Gln438Glu Single submitter ⚠
- p.Glu176Lys Single submitter ⚠
- p.Glu205Lys Single submitter
- p.Glu274Lys Single submitter ⚠
- p.Glu300Gly Single submitter ⚠
- p.Glu481Asp Single submitter ⚠
- p.Glu6Ala Single submitter ⚠
- p.Gly252Arg Single submitter ⚠
- p.Ile199Thr Single submitter ⚠
- p.Ile80Leu Single submitter ⚠
- p.Leu102Val Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu217Pro Single submitter ⚠
- p.Leu249Met Single submitter ⚠
- p.Leu331Ile Single submitter ⚠
- p.Leu331Val Single submitter ⚠
- p.Leu493Phe Single submitter ⚠
- p.Lys120Thr Single submitter ⚠
- p.Lys255Ter Single submitter
- p.Lys421Glu Single submitter ⚠
- p.Lys484Glu Single submitter ⚠
- p.Lys94Gln Single submitter
- p.Phe108Leu Single submitter ⚠
- p.Pro289Ala Single submitter ⚠
- p.Pro315Ser Single submitter
- p.Ser130Asn Single submitter
- p.Ser185Phe Single submitter ⚠
- p.Ser195Tyr Single submitter ⚠
- p.Ser27Asn Single submitter ⚠
- p.Thr36Ala Single submitter ⚠
- p.Tyr151His Single submitter ⚠
- p.Tyr156Asn Single submitter ⚠
- p.Tyr156Cys Single submitter ⚠
- p.Tyr156His Single submitter ⚠
- p.Tyr248Cys Single submitter ⚠
- p.Tyr257Asn Single submitter
- p.Tyr310His Single submitter ⚠
- p.Val107Ile Single submitter ⚠
- p.Val323Ile Single submitter ⚠
- p.Val395Ala Single submitter ⚠