DEPP1 — 5 ClinVar variants
All ClinVar germline DEPP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
1 Benign · 2 Likely benign · 2 Uncertain significance
Full DEPP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 1
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All DEPP1 variants
Benign 1
- p.Thr101Ala Multiple submitters
Likely benign 2
- p.Arg83Gln Single submitter
- p.Arg88Cys Single submitter ⚠
Uncertain significance 2
- p.Ser183Phe Single submitter ⚠
- p.Val9Met Single submitter ⚠