DEPTOR — 67 ClinVar variants

All ClinVar germline DEPTOR variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →

1 Conflicting · 4 Likely benign · 62 Uncertain significance

Full DEPTOR gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 61

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

DEPTOR p.Arg345Gln Conflicting Single submitter

Predictors lean, ClinVar uncertain 43

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 17

The independent predictors disagree with each other — read with care.

All DEPTOR variants

Conflicting classifications of pathogenicity 1

p.Arg345Gln Single submitter ⚠

Likely benign 4

p.Arg53= Single submitter
p.Asn232Ser Single submitter
p.Asp336= Single submitter
p.Pro322= Single submitter

Uncertain significance 62

p.Ala132Ser Single submitter ⚠
p.Ala132Val Single submitter ⚠
p.Ala337Val Single submitter ⚠
p.Ala363Thr Single submitter ⚠
p.Arg116His Single submitter ⚠
p.Arg163His Single submitter
p.Arg222Gly Single submitter ⚠
p.Arg222Trp Single submitter ⚠
p.Arg256Gln Single submitter ⚠
p.Arg25Thr Single submitter ⚠
p.Asn232Asp Single submitter ⚠
p.Asn379Asp Single submitter ⚠
p.Asp384Gly Single submitter ⚠
p.Cys304Gly Single submitter ⚠
p.Cys369Tyr Single submitter ⚠
p.Gln176Arg Single submitter ⚠
p.Gln370Pro Single submitter ⚠
p.Glu107Lys Single submitter ⚠
p.Glu162Asp Single submitter ⚠
p.Glu179Asp Single submitter ⚠
p.Glu185Asp Single submitter ⚠
p.Glu187Lys Single submitter ⚠
p.Glu195Asp Single submitter ⚠
p.Glu269Asp Single submitter ⚠
p.Glu26Asp Single submitter ⚠
p.Glu2Val Single submitter ⚠
p.Gly21Glu Single submitter ⚠
p.Gly323Arg Single submitter
p.Gly377Arg Single submitter ⚠
p.His105Gln Single submitter ⚠
p.His55Tyr Single submitter ⚠
p.His76Arg Single submitter ⚠
p.Ile74Thr Single submitter ⚠
p.Ile97Phe Single submitter ⚠
p.Leu150Phe Single submitter ⚠
p.Leu27Met Single submitter ⚠
p.Lys257Ile Single submitter ⚠
p.Met228Ile Single submitter ⚠
p.Met30Val Single submitter ⚠
p.Phe114Leu Single submitter ⚠
p.Phe246Ser Single submitter ⚠
p.Pro301Thr Single submitter ⚠
p.Pro322Ser Single submitter ⚠
p.Pro396Leu Single submitter ⚠
p.Ser12Asn Single submitter ⚠
p.Ser263Pro Single submitter ⚠
p.Ser274Cys Single submitter ⚠
p.Ser292Asn Single submitter ⚠
p.Ser298Asn Single submitter ⚠
p.Thr182Lys Single submitter ⚠
p.Thr394Met Single submitter ⚠
p.Thr398Met Single submitter ⚠
p.Thr59Ser Single submitter ⚠
p.Tyr215Cys Single submitter ⚠
p.Tyr289His Single submitter ⚠
p.Val159Phe Single submitter ⚠
p.Val209Met Single submitter ⚠
p.Val273Leu Single submitter ⚠
p.Val302Met Single submitter ⚠
p.Val334Ala Single submitter ⚠
p.Val373Ile Single submitter ⚠
p.Val400Ala Single submitter ⚠