DEXI — 18 ClinVar variants
All ClinVar germline DEXI variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 18 flagged for review →
18 Uncertain significance
Full DEXI gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 18
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DEXI p.Ala12Gly Uncertain significance Single submitter
- DEXI p.Ala4Val Uncertain significance Single submitter
- DEXI p.Asn37Ser Uncertain significance Single submitter
- DEXI p.His9Pro Uncertain significance Single submitter
- DEXI p.Leu10Val Uncertain significance Single submitter
- DEXI p.Leu13Val Uncertain significance Single submitter
- DEXI p.Leu24Val Uncertain significance Single submitter
- DEXI p.Leu73Phe Uncertain significance Single submitter
- DEXI p.Pro15Ser Uncertain significance Single submitter
- DEXI p.Val36Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DEXI p.Asp88His Uncertain significance Single submitter
- DEXI p.Leu70Ile Uncertain significance Single submitter
- DEXI p.Phe34Leu Uncertain significance Single submitter
- DEXI p.Pro76Ser Uncertain significance Single submitter
- DEXI p.Ser74Phe Uncertain significance Single submitter
- DEXI p.Ser85Trp Uncertain significance Single submitter
- DEXI p.Val31Gly Uncertain significance Single submitter
- DEXI p.Val54Leu Uncertain significance Single submitter
All DEXI variants
Uncertain significance 18
- p.Ala12Gly Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Asn37Ser Single submitter ⚠
- p.Asp88His Single submitter ⚠
- p.His9Pro Single submitter ⚠
- p.Leu10Val Single submitter ⚠
- p.Leu13Val Single submitter ⚠
- p.Leu24Val Single submitter ⚠
- p.Leu70Ile Single submitter ⚠
- p.Leu73Phe Single submitter ⚠
- p.Phe34Leu Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro76Ser Single submitter ⚠
- p.Ser74Phe Single submitter ⚠
- p.Ser85Trp Single submitter ⚠
- p.Val31Gly Single submitter ⚠
- p.Val36Ile Single submitter ⚠
- p.Val54Leu Single submitter ⚠