DGAT2L6 — 62 ClinVar variants
All ClinVar germline DGAT2L6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Benign · 12 Likely benign · 49 Uncertain significance
Full DGAT2L6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DGAT2L6 p.Arg129Gln Uncertain significance Single submitter
- DGAT2L6 p.Arg281Gln Uncertain significance Single submitter
- DGAT2L6 p.Arg316Cys Uncertain significance Single submitter
- DGAT2L6 p.Arg6Gln Uncertain significance Single submitter
- DGAT2L6 p.Asn119Ser Uncertain significance Single submitter
- DGAT2L6 p.Asn300Lys Uncertain significance Single submitter
- DGAT2L6 p.Asp95Asn Uncertain significance Single submitter
- DGAT2L6 p.Gly177Val Uncertain significance Single submitter
- DGAT2L6 p.Gly226Asp Uncertain significance Single submitter
- DGAT2L6 p.Gly272Arg Uncertain significance Single submitter
- DGAT2L6 p.His94Asn Uncertain significance Single submitter
- DGAT2L6 p.His94Gln Uncertain significance Single submitter
- DGAT2L6 p.Ile36Thr Uncertain significance Single submitter
- DGAT2L6 p.Leu244Ser Uncertain significance Single submitter
- DGAT2L6 p.Leu244Trp Uncertain significance Single submitter
- DGAT2L6 p.Lys174Asn Uncertain significance Single submitter
- DGAT2L6 p.Lys302Asn Uncertain significance Single submitter
- DGAT2L6 p.Met211Val Uncertain significance Single submitter
- DGAT2L6 p.Phe261Cys Uncertain significance Single submitter
- DGAT2L6 p.Phe27Ser Uncertain significance Single submitter
- DGAT2L6 p.Pro23Ser Uncertain significance Single submitter
- DGAT2L6 p.Pro278His Uncertain significance Single submitter
- DGAT2L6 p.Pro282His Uncertain significance Single submitter
- DGAT2L6 p.Pro329Leu Uncertain significance Single submitter
- DGAT2L6 p.Ser133Pro Uncertain significance Single submitter
- DGAT2L6 p.Ser64Thr Uncertain significance Single submitter
- DGAT2L6 p.Thr235Asn Uncertain significance Single submitter
- DGAT2L6 p.Thr263Ile Uncertain significance Single submitter
- DGAT2L6 p.Tyr218His Uncertain significance Single submitter
- DGAT2L6 p.Val181Leu Uncertain significance Single submitter
-
DGAT2L6 p.Leu257Met
Uncertain significance
No assertion criteria
prostate cancer
-
DGAT2L6 p.Leu310Phe
Uncertain significance
No assertion criteria
DGAT2L6-related disorder
Predictors split 14
The independent predictors disagree with each other — read with care.
- DGAT2L6 p.Ala314Val Uncertain significance Single submitter
- DGAT2L6 p.Arg281Trp Uncertain significance Single submitter
- DGAT2L6 p.Arg69Cys Uncertain significance Single submitter
- DGAT2L6 p.Asn178Ser Uncertain significance Single submitter
- DGAT2L6 p.Glu229Lys Uncertain significance Single submitter
- DGAT2L6 p.Gly196Glu Uncertain significance Single submitter
- DGAT2L6 p.Leu9Pro Uncertain significance Single submitter
- DGAT2L6 p.Met155Ile Uncertain significance Single submitter
- DGAT2L6 p.Phe117Leu Uncertain significance Single submitter
- DGAT2L6 p.Phe16Ser Uncertain significance Single submitter
- DGAT2L6 p.Pro294Leu Uncertain significance Single submitter
- DGAT2L6 p.Thr240Met Uncertain significance Single submitter
- DGAT2L6 p.Trp21Arg Uncertain significance Single submitter
-
DGAT2L6 p.Arg129Trp
Likely benign
No assertion criteria
DGAT2L6-related disorder
All DGAT2L6 variants
Benign 1
- c.267+8C>T Single submitter
Likely benign 12
- p.Arg194Gln Single submitter
- p.Arg298Lys Single submitter
- p.Arg83Gln Single submitter
- p.Asn228= Single submitter
- p.Leu112Val Single submitter
- p.Thr57= Single submitter
- p.Val88Ile Single submitter
- p.Arg129Trp No assertion criteria DGAT2L6-related disorder ⚠
- p.Arg267= No assertion criteria DGAT2L6-related disorder
- p.Phe45Ile No assertion criteria DGAT2L6-related disorder
- p.Tyr326= No assertion criteria DGAT2L6-related disorder
- p.Tyr58= No assertion criteria DGAT2L6-related disorder
Uncertain significance 49
- c.472+3G>A Single submitter
- p.Ala314Val Single submitter ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg194Pro Single submitter
- p.Arg281Gln Single submitter ⚠
- p.Arg281Trp Single submitter ⚠
- p.Arg316Cys Single submitter ⚠
- p.Arg69Cys Single submitter ⚠
- p.Arg6Gln Single submitter ⚠
- p.Asn119Ser Single submitter ⚠
- p.Asn178Ser Single submitter ⚠
- p.Asn300Lys Single submitter ⚠
- p.Asp95Asn Single submitter ⚠
- p.Glu229Lys Single submitter ⚠
- p.Gly177Val Single submitter ⚠
- p.Gly196Glu Single submitter ⚠
- p.Gly226Asp Single submitter ⚠
- p.Gly272Arg Single submitter ⚠
- p.His94Asn Single submitter ⚠
- p.His94Gln Single submitter ⚠
- p.Ile36Thr Single submitter ⚠
- p.Leu244Ser Single submitter ⚠
- p.Leu244Trp Single submitter ⚠
- p.Leu9Pro Single submitter ⚠
- p.Lys174Asn Single submitter ⚠
- p.Lys302Asn Single submitter ⚠
- p.Met155Ile Single submitter ⚠
- p.Met211Val Single submitter ⚠
- p.Phe117Leu Single submitter ⚠
- p.Phe16Ser Single submitter ⚠
- p.Phe261Cys Single submitter ⚠
- p.Phe27Ser Single submitter ⚠
- p.Pro23Ser Single submitter ⚠
- p.Pro278His Single submitter ⚠
- p.Pro282His Single submitter ⚠
- p.Pro294Leu Single submitter ⚠
- p.Pro329Leu Single submitter ⚠
- p.Ser133Pro Single submitter ⚠
- p.Ser64Thr Single submitter ⚠
- p.Thr140Asn Single submitter
- p.Thr215Ile Single submitter
- p.Thr235Asn Single submitter ⚠
- p.Thr240Met Single submitter ⚠
- p.Thr263Ile Single submitter ⚠
- p.Trp21Arg Single submitter ⚠
- p.Tyr218His Single submitter ⚠
- p.Val181Leu Single submitter ⚠
- p.Leu257Met No assertion criteria prostate cancer ⚠
- p.Leu310Phe No assertion criteria DGAT2L6-related disorder ⚠