DGCR6 — 55 ClinVar variants
All ClinVar germline DGCR6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Benign · 5 Likely benign · 48 Uncertain significance
Full DGCR6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DGCR6 p.Arg108Gln Uncertain significance Single submitter
- DGCR6 p.Arg108Gly Uncertain significance Single submitter
- DGCR6 p.Arg121Gln Uncertain significance Single submitter
- DGCR6 p.Arg135Gln Uncertain significance Single submitter
- DGCR6 p.Arg184Gln Uncertain significance Single submitter
- DGCR6 p.Arg97Gln Uncertain significance Single submitter
- DGCR6 p.Asp212Asn Uncertain significance Single submitter
- DGCR6 p.Gln210Arg Uncertain significance Single submitter
- DGCR6 p.Gln210Leu Uncertain significance Single submitter
- DGCR6 p.Glu10Lys Uncertain significance Single submitter
- DGCR6 p.Gly14Ser Uncertain significance Single submitter
- DGCR6 p.Gly160Arg Uncertain significance Single submitter
- DGCR6 p.Gly201Glu Uncertain significance Single submitter
- DGCR6 p.Gly202Ser Uncertain significance Single submitter
- DGCR6 p.Gly215Ala Uncertain significance Single submitter
- DGCR6 p.Gly58Arg Uncertain significance Single submitter
- DGCR6 p.Ile183Val Uncertain significance Single submitter
- DGCR6 p.Leu180Pro Uncertain significance Single submitter
- DGCR6 p.Leu28Val Uncertain significance Single submitter
- DGCR6 p.Lys148Arg Uncertain significance Single submitter
- DGCR6 p.Pro219Leu Uncertain significance Single submitter
- DGCR6 p.Tyr4Cys Uncertain significance Single submitter
- DGCR6 p.Val114Gly Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
- DGCR6 p.Ala103Val Uncertain significance Single submitter
- DGCR6 p.Ala125Val Uncertain significance Single submitter
- DGCR6 p.Ala136Thr Uncertain significance Single submitter
- DGCR6 p.Ala136Val Uncertain significance Single submitter
- DGCR6 p.Arg108Trp Uncertain significance Single submitter
- DGCR6 p.Arg129Gln Uncertain significance Single submitter
- DGCR6 p.Arg129Gly Uncertain significance Single submitter
- DGCR6 p.Arg135Trp Uncertain significance Single submitter
- DGCR6 p.Arg147Gln Likely benign Single submitter
- DGCR6 p.Gln188His Uncertain significance Single submitter
- DGCR6 p.Glu157Gln Uncertain significance Single submitter
- DGCR6 p.His72Gln Uncertain significance Single submitter
- DGCR6 p.His72Tyr Uncertain significance Single submitter
- DGCR6 p.His89Tyr Uncertain significance Single submitter
- DGCR6 p.Ile130Leu Uncertain significance Single submitter
- DGCR6 p.Leu56Phe Uncertain significance Single submitter
- DGCR6 p.Leu85Gln Uncertain significance Single submitter
- DGCR6 p.Leu8Trp Uncertain significance Single submitter
- DGCR6 p.Lys158Asn Uncertain significance Single submitter
- DGCR6 p.Lys76Asn Uncertain significance Single submitter
- DGCR6 p.Ser49Arg Uncertain significance Single submitter
- DGCR6 p.Thr168Ala Uncertain significance Single submitter
- DGCR6 p.Tyr165His Uncertain significance Single submitter
- DGCR6 p.Tyr22Cys Uncertain significance Single submitter
- DGCR6 p.Val166Gly Uncertain significance Single submitter
- DGCR6 p.Val32Met Uncertain significance Single submitter
All DGCR6 variants
Benign 2
- p.Leu8= Multiple submitters
- c.373-6C>T Single submitter
Likely benign 5
- p.Arg147Gln Single submitter ⚠
- p.His110= Single submitter
- p.Leu24= Single submitter
- p.Lys140= Single submitter
- p.Pro220Leu Single submitter
Uncertain significance 48
- p.Ala103Val Single submitter ⚠
- p.Ala125Val Single submitter ⚠
- p.Ala136Thr Single submitter ⚠
- p.Ala136Val Single submitter ⚠
- p.Arg108Gln Single submitter ⚠
- p.Arg108Gly Single submitter ⚠
- p.Arg108Trp Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg129Gln Single submitter ⚠
- p.Arg129Gly Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg135Trp Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg97Gln Single submitter ⚠
- p.Asp212Asn Single submitter ⚠
- p.Gln188His Single submitter ⚠
- p.Gln210Arg Single submitter ⚠
- p.Gln210Leu Single submitter ⚠
- p.Glu10Lys Single submitter ⚠
- p.Glu157Gln Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly160Arg Single submitter ⚠
- p.Gly201Glu Single submitter ⚠
- p.Gly202Ser Single submitter ⚠
- p.Gly215Ala Single submitter ⚠
- p.Gly58Arg Single submitter ⚠
- p.His72Gln Single submitter ⚠
- p.His72Tyr Single submitter ⚠
- p.His89Tyr Single submitter ⚠
- p.Ile130Leu Single submitter ⚠
- p.Ile183Val Single submitter ⚠
- p.Leu180Pro Single submitter ⚠
- p.Leu28Val Single submitter ⚠
- p.Leu56Phe Single submitter ⚠
- p.Leu85Gln Single submitter ⚠
- p.Leu8Trp Single submitter ⚠
- p.Lys148Arg Single submitter ⚠
- p.Lys158Asn Single submitter ⚠
- p.Lys76Asn Single submitter ⚠
- p.Pro219Leu Single submitter ⚠
- p.Ser49Arg Single submitter ⚠
- p.Thr168Ala Single submitter ⚠
- p.Tyr165His Single submitter ⚠
- p.Tyr22Cys Single submitter ⚠
- p.Tyr4Cys Single submitter ⚠
- p.Val114Gly Single submitter ⚠
- p.Val166Gly Single submitter ⚠
- p.Val32Met Single submitter ⚠