DGCR6L — 36 ClinVar variants
All ClinVar germline DGCR6L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
2 Likely benign · 34 Uncertain significance
Full DGCR6L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DGCR6L p.Ala52Asp Uncertain significance Single submitter
- DGCR6L p.Ala5Thr Uncertain significance Single submitter
- DGCR6L p.Arg121Gln Uncertain significance Single submitter
- DGCR6L p.Arg135Gln Uncertain significance Single submitter
- DGCR6L p.Asn169Asp Uncertain significance Single submitter
- DGCR6L p.Gln104Arg Uncertain significance Single submitter
- DGCR6L p.Glu10Asp Uncertain significance Single submitter
- DGCR6L p.Glu9Asp Uncertain significance Single submitter
- DGCR6L p.Gly190Ser Uncertain significance Single submitter
- DGCR6L p.Leu55Phe Uncertain significance Single submitter
- DGCR6L p.Lys185Gln Uncertain significance Single submitter
- DGCR6L p.Pro219Ala Uncertain significance Single submitter
- DGCR6L p.Tyr79Asn Uncertain significance Single submitter
- DGCR6L p.Val126Met Uncertain significance Single submitter
- DGCR6L p.Val91Ala Uncertain significance Single submitter
-
DGCR6L p.Pro203Leu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 18
The independent predictors disagree with each other — read with care.
- DGCR6L p.Ala136Glu Uncertain significance Single submitter
- DGCR6L p.Ala136Val Uncertain significance Single submitter
- DGCR6L p.Ala159Val Uncertain significance Single submitter
- DGCR6L p.Arg129Trp Uncertain significance Single submitter
- DGCR6L p.Arg131Cys Uncertain significance Single submitter
- DGCR6L p.Arg131His Uncertain significance Single submitter
- DGCR6L p.Arg192Trp Uncertain significance Single submitter
- DGCR6L p.Arg82Cys Uncertain significance Single submitter
- DGCR6L p.Arg97Gly Uncertain significance Single submitter
- DGCR6L p.Glu122Gln Uncertain significance Single submitter
- DGCR6L p.Glu127Gly Uncertain significance Single submitter
- DGCR6L p.Glu34Lys Uncertain significance Single submitter
- DGCR6L p.Leu182Phe Uncertain significance Single submitter
- DGCR6L p.Leu73Phe Uncertain significance Single submitter
- DGCR6L p.Leu96Pro Uncertain significance Single submitter
- DGCR6L p.Met137Ile Uncertain significance Single submitter
- DGCR6L p.Pro113Leu Uncertain significance Single submitter
- DGCR6L p.Ser38Phe Uncertain significance Single submitter
All DGCR6L variants
Likely benign 2
- p.Arg192Gln Single submitter
- p.Asp212Gly Single submitter
Uncertain significance 34
- p.Ala136Glu Single submitter ⚠
- p.Ala136Val Single submitter ⚠
- p.Ala159Val Single submitter ⚠
- p.Ala52Asp Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg129Trp Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg192Trp Single submitter ⚠
- p.Arg82Cys Single submitter ⚠
- p.Arg97Gly Single submitter ⚠
- p.Asn169Asp Single submitter ⚠
- p.Gln104Arg Single submitter ⚠
- p.Glu10Asp Single submitter ⚠
- p.Glu122Gln Single submitter ⚠
- p.Glu127Gly Single submitter ⚠
- p.Glu34Lys Single submitter ⚠
- p.Glu9Asp Single submitter ⚠
- p.Gly190Ser Single submitter ⚠
- p.Leu182Phe Single submitter ⚠
- p.Leu55Phe Single submitter ⚠
- p.Leu73Phe Single submitter ⚠
- p.Leu96Pro Single submitter ⚠
- p.Lys185Gln Single submitter ⚠
- p.Met137Ile Single submitter ⚠
- p.Pro113Leu Single submitter ⚠
- p.Pro219Ala Single submitter ⚠
- p.Ser38Phe Single submitter ⚠
- p.Tyr79Asn Single submitter ⚠
- p.Val126Met Single submitter ⚠
- p.Val91Ala Single submitter ⚠
- p.Pro203Leu No assertion criteria prostate cancer ⚠