DGKG — 134 ClinVar variants
All ClinVar germline DGKG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 123 flagged for review →
1 Pathogenic · 2 Benign · 4 Likely benign · 127 Uncertain significance
Full DGKG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 123
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 95
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DGKG p.Ala140Thr Uncertain significance Single submitter
- DGKG p.Ala141Val Uncertain significance Single submitter
- DGKG p.Ala273Thr Uncertain significance Single submitter
- DGKG p.Ala589Thr Uncertain significance Single submitter
- DGKG p.Ala61Val Uncertain significance Single submitter
- DGKG p.Ala656Ser Uncertain significance Single submitter
- DGKG p.Ala768Val Uncertain significance Single submitter
- DGKG p.Arg150Trp Uncertain significance Single submitter
- DGKG p.Arg185Cys Uncertain significance Single submitter
- DGKG p.Arg185His Uncertain significance Single submitter
- DGKG p.Arg375His Uncertain significance Single submitter
- DGKG p.Arg486Gly Uncertain significance Single submitter
- DGKG p.Arg530Cys Uncertain significance Single submitter
- DGKG p.Arg530His Uncertain significance Single submitter
- DGKG p.Arg5Gln Uncertain significance Single submitter
- DGKG p.Arg677Gly Uncertain significance Single submitter
- DGKG p.Arg788His Uncertain significance Single submitter
- DGKG p.Asn317Thr Uncertain significance Single submitter
- DGKG p.Asn36Ser Uncertain significance Single submitter
- DGKG p.Asn97Lys Uncertain significance Single submitter
- DGKG p.Asp15Asn Uncertain significance Single submitter
- DGKG p.Asp262Asn Uncertain significance Single submitter
- DGKG p.Asp262Gly Uncertain significance Single submitter
- DGKG p.Asp349Asn Uncertain significance Single submitter
- DGKG p.Asp404Ala Uncertain significance Single submitter
- DGKG p.Asp572Tyr Uncertain significance Single submitter
- DGKG p.Asp66Glu Uncertain significance Single submitter
- DGKG p.Asp89Ala Uncertain significance Single submitter
- DGKG p.Cys302Phe Uncertain significance Single submitter
- DGKG p.Cys369Trp Uncertain significance Single submitter
- DGKG p.Cys502Tyr Uncertain significance Single submitter
- DGKG p.Cys757Gly Uncertain significance Single submitter
- DGKG p.Gln138Arg Uncertain significance Single submitter
- DGKG p.Gln212Arg Uncertain significance Single submitter
- DGKG p.Glu118Lys Uncertain significance Single submitter
- DGKG p.Glu145Lys Uncertain significance Single submitter
- DGKG p.Glu191Asp Uncertain significance Single submitter
- DGKG p.Glu682Gly Uncertain significance Single submitter
- DGKG p.Glu86Lys Uncertain significance Single submitter
- DGKG p.Gly231Arg Uncertain significance Single submitter
- DGKG p.Gly260Glu Uncertain significance Single submitter
- DGKG p.Gly299Val Uncertain significance Single submitter
- DGKG p.Gly38Val Uncertain significance Single submitter
- DGKG p.Gly494Glu Uncertain significance Single submitter
- DGKG p.Gly642Arg Uncertain significance Single submitter
- DGKG p.Gly686Asp Uncertain significance Single submitter
- DGKG p.Gly750Glu Uncertain significance Single submitter
- DGKG p.Gly94Glu Uncertain significance Single submitter
- DGKG p.His289Tyr Uncertain significance Single submitter
- DGKG p.His374Pro Uncertain significance Single submitter
- DGKG p.His511Arg Uncertain significance Single submitter
- DGKG p.Ile503Val Uncertain significance Single submitter
- DGKG p.Ile547Val Uncertain significance Single submitter
- DGKG p.Ile563Leu Uncertain significance Single submitter
- DGKG p.Ile563Val Uncertain significance Single submitter
- DGKG p.Ile591Thr Uncertain significance Single submitter
- DGKG p.Ile636Val Uncertain significance Single submitter
- DGKG p.Ile657Val Uncertain significance Single submitter
- DGKG p.Leu458Met Uncertain significance Single submitter
- DGKG p.Leu71Pro Uncertain significance Single submitter
- DGKG p.Lys281Arg Uncertain significance Single submitter
- DGKG p.Lys29Glu Uncertain significance Single submitter
- DGKG p.Lys442Arg Uncertain significance Single submitter
- DGKG p.Lys510Arg Uncertain significance Single submitter
- DGKG p.Lys605Thr Uncertain significance Single submitter
- DGKG p.Phe79Ser Uncertain significance Single submitter
- DGKG p.Pro134Ser Uncertain significance Single submitter
- DGKG p.Pro143Thr Uncertain significance Single submitter
- DGKG p.Pro406Ala Uncertain significance Single submitter
- DGKG p.Pro428Thr Uncertain significance Single submitter
- DGKG p.Pro430Ser Uncertain significance Single submitter
- DGKG p.Pro551Arg Uncertain significance Single submitter
- DGKG p.Pro551Ser Uncertain significance Single submitter
- DGKG p.Ser102Asn Uncertain significance Single submitter
- DGKG p.Ser156Pro Uncertain significance Single submitter
- DGKG p.Ser21Leu Uncertain significance Single submitter
- DGKG p.Ser40Ile Uncertain significance Single submitter
- DGKG p.Ser51Asn Uncertain significance Single submitter
- DGKG p.Ser648Arg Uncertain significance Single submitter
- DGKG p.Ser778Thr Uncertain significance Single submitter
- DGKG p.Ser782Leu Uncertain significance Single submitter
- DGKG p.Thr114Ser Uncertain significance Single submitter
- DGKG p.Thr324Lys Uncertain significance Single submitter
- DGKG p.Thr432Pro Uncertain significance Single submitter
- DGKG p.Thr92Met Uncertain significance Single submitter
- DGKG p.Trp274Arg Uncertain significance Single submitter
- DGKG p.Trp339Arg Uncertain significance Single submitter
- DGKG p.Tyr187Cys Uncertain significance Single submitter
- DGKG p.Val159Ile Uncertain significance Single submitter
- DGKG p.Val165Met Uncertain significance Single submitter
- DGKG p.Val295Phe Uncertain significance Single submitter
- DGKG p.Val346Phe Uncertain significance Single submitter
- DGKG p.Val414Met Uncertain significance Single submitter
- DGKG p.Val65Gly Uncertain significance Single submitter
- DGKG p.Val708Met Uncertain significance Single submitter
Predictors split 28
The independent predictors disagree with each other — read with care.
- DGKG p.Ala31Asp Uncertain significance Single submitter
- DGKG p.Arg271Trp Uncertain significance Single submitter
- DGKG p.Arg296Cys Uncertain significance Single submitter
- DGKG p.Arg375Cys Uncertain significance Single submitter
- DGKG p.Arg446Thr Uncertain significance Single submitter
- DGKG p.Arg453Trp Uncertain significance Single submitter
- DGKG p.Arg480Cys Uncertain significance Single submitter
- DGKG p.Arg480His Likely benign Single submitter
- DGKG p.Arg677Trp Uncertain significance Single submitter
- DGKG p.Asp45Glu Uncertain significance Single submitter
- DGKG p.Gln359His Uncertain significance Single submitter
- DGKG p.Glu600Gln Uncertain significance Single submitter
- DGKG p.Gly238Ser Uncertain significance Single submitter
- DGKG p.Gly537Ala Uncertain significance Single submitter
- DGKG p.Gly537Val Uncertain significance Single submitter
- DGKG p.Ile28Thr Uncertain significance Single submitter
- DGKG p.Leu41Phe Uncertain significance Single submitter
- DGKG p.Leu57Pro Uncertain significance Single submitter
- DGKG p.Lys765Glu Uncertain significance Single submitter
- DGKG p.Met232Thr Uncertain significance Single submitter
- DGKG p.Met770Ile Uncertain significance Single submitter
- DGKG p.Pro395Ser Uncertain significance Single submitter
- DGKG p.Pro49Leu Uncertain significance Single submitter
- DGKG p.Pro774Leu Uncertain significance Single submitter
- DGKG p.Ser354Cys Uncertain significance Single submitter
- DGKG p.Thr251Ala Uncertain significance Single submitter
- DGKG p.Thr324Met Uncertain significance Single submitter
- DGKG p.Thr628Asn Uncertain significance Single submitter
All DGKG variants
Pathogenic 1
- p.Met183fs No assertion criteria hypercholesterolemia, familial, 1
Likely benign 4
- p.Arg480His Single submitter ⚠
- p.Arg739= Single submitter
- p.Asp504= Single submitter
- p.Val697Ile Single submitter
Uncertain significance 127
- p.Ala140Thr Single submitter ⚠
- p.Ala141Val Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala31Asp Single submitter ⚠
- p.Ala589Thr Single submitter ⚠
- p.Ala61Val Single submitter ⚠
- p.Ala656Ser Single submitter ⚠
- p.Ala768Val Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg185Cys Single submitter ⚠
- p.Arg185His Single submitter ⚠
- p.Arg222Ser Single submitter
- p.Arg271Trp Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg446Thr Single submitter ⚠
- p.Arg453Trp Single submitter ⚠
- p.Arg480Cys Single submitter ⚠
- p.Arg486Gly Single submitter ⚠
- p.Arg530Cys Single submitter ⚠
- p.Arg530His Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg677Gly Single submitter ⚠
- p.Arg677Trp Single submitter ⚠
- p.Arg788His Single submitter ⚠
- p.Asn317Thr Single submitter ⚠
- p.Asn36Ser Single submitter ⚠
- p.Asn97Lys Single submitter ⚠
- p.Asp15Asn Single submitter ⚠
- p.Asp262Asn Single submitter ⚠
- p.Asp262Gly Single submitter ⚠
- p.Asp349Asn Single submitter ⚠
- p.Asp404Ala Single submitter ⚠
- p.Asp45Glu Single submitter ⚠
- p.Asp572Tyr Single submitter ⚠
- p.Asp66Glu Single submitter ⚠
- p.Asp89Ala Single submitter ⚠
- p.Cys302Phe Single submitter ⚠
- p.Cys369Trp Single submitter ⚠
- p.Cys502Tyr Single submitter ⚠
- p.Cys757Gly Single submitter ⚠
- p.Gln138Arg Single submitter ⚠
- p.Gln212Arg Single submitter ⚠
- p.Gln359His Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu145Lys Single submitter ⚠
- p.Glu191Asp Single submitter ⚠
- p.Glu600Gln Single submitter ⚠
- p.Glu682Gly Single submitter ⚠
- p.Glu86Lys Single submitter ⚠
- p.Gly231Arg Single submitter ⚠
- p.Gly238Ser Single submitter ⚠
- p.Gly260Glu Single submitter ⚠
- p.Gly299Val Single submitter ⚠
- p.Gly38Val Single submitter ⚠
- p.Gly494Glu Single submitter ⚠
- p.Gly537Ala Single submitter ⚠
- p.Gly537Val Single submitter ⚠
- p.Gly642Arg Single submitter ⚠
- p.Gly686Asp Single submitter ⚠
- p.Gly750Glu Single submitter ⚠
- p.Gly94Glu Single submitter ⚠
- p.His289Tyr Single submitter ⚠
- p.His374Pro Single submitter ⚠
- p.His511Arg Single submitter ⚠
- p.Ile28Thr Single submitter ⚠
- p.Ile503Val Single submitter ⚠
- p.Ile547Val Single submitter ⚠
- p.Ile563Leu Single submitter ⚠
- p.Ile563Val Single submitter ⚠
- p.Ile591Thr Single submitter ⚠
- p.Ile636Val Single submitter ⚠
- p.Ile657Val Single submitter ⚠
- p.Leu41Phe Single submitter ⚠
- p.Leu458Met Single submitter ⚠
- p.Leu57Pro Single submitter ⚠
- p.Leu658Val Single submitter
- p.Leu71Pro Single submitter ⚠
- p.Lys281Arg Single submitter ⚠
- p.Lys29Glu Single submitter ⚠
- p.Lys442Arg Single submitter ⚠
- p.Lys510Arg Single submitter ⚠
- p.Lys605Thr Single submitter ⚠
- p.Lys765Glu Single submitter ⚠
- p.Met232Thr Single submitter ⚠
- p.Met770Ile Single submitter ⚠
- p.Phe79Ser Single submitter ⚠
- p.Pro134Ser Single submitter ⚠
- p.Pro143Thr Single submitter ⚠
- p.Pro395Ser Single submitter ⚠
- p.Pro406Ala Single submitter ⚠
- p.Pro428Thr Single submitter ⚠
- p.Pro430Ser Single submitter ⚠
- p.Pro49Leu Single submitter ⚠
- p.Pro551Arg Single submitter ⚠
- p.Pro551Ser Single submitter ⚠
- p.Pro774Leu Single submitter ⚠
- p.Ser102Asn Single submitter ⚠
- p.Ser156Pro Single submitter ⚠
- p.Ser169Tyr Single submitter
- p.Ser21Leu Single submitter ⚠
- p.Ser354Cys Single submitter ⚠
- p.Ser40Ile Single submitter ⚠
- p.Ser51Asn Single submitter ⚠
- p.Ser648Arg Single submitter ⚠
- p.Ser778Thr Single submitter ⚠
- p.Ser782Leu Single submitter ⚠
- p.Thr114Ser Single submitter ⚠
- p.Thr251Ala Single submitter ⚠
- p.Thr308Ala Single submitter
- p.Thr324Lys Single submitter ⚠
- p.Thr324Met Single submitter ⚠
- p.Thr432Pro Single submitter ⚠
- p.Thr628Asn Single submitter ⚠
- p.Thr92Met Single submitter ⚠
- p.Trp274Arg Single submitter ⚠
- p.Trp339Arg Single submitter ⚠
- p.Tyr187Cys Single submitter ⚠
- p.Val159Ile Single submitter ⚠
- p.Val165Met Single submitter ⚠
- p.Val295Phe Single submitter ⚠
- p.Val346Phe Single submitter ⚠
- p.Val367Met Single submitter
- p.Val414Met Single submitter ⚠
- p.Val65Gly Single submitter ⚠
- p.Val708Met Single submitter ⚠