DGKI — 131 ClinVar variants
All ClinVar germline DGKI variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
1 Likely benign · 130 Uncertain significance
Full DGKI gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 94
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DGKI p.Ala101Gly Uncertain significance Single submitter
- DGKI p.Ala1037Thr Uncertain significance Single submitter
- DGKI p.Ala107Val Uncertain significance Single submitter
- DGKI p.Ala15Glu Uncertain significance Single submitter
- DGKI p.Ala20Val Uncertain significance Single submitter
- DGKI p.Ala220Thr Uncertain significance Single submitter
- DGKI p.Ala28Gly Uncertain significance Single submitter
- DGKI p.Ala47Val Uncertain significance Single submitter
- DGKI p.Ala48Val Uncertain significance Single submitter
- DGKI p.Ala4Glu Uncertain significance Single submitter
- DGKI p.Ala59Thr Uncertain significance Single submitter
- DGKI p.Ala650Val Uncertain significance Single submitter
- DGKI p.Ala65Val Uncertain significance Single submitter
- DGKI p.Ala689Ser Uncertain significance Single submitter
- DGKI p.Ala92Ser Uncertain significance Single submitter
- DGKI p.Arg1042Cys Uncertain significance Single submitter
- DGKI p.Arg1042His Uncertain significance Single submitter
- DGKI p.Arg164Thr Uncertain significance Single submitter
- DGKI p.Arg257Cys Uncertain significance Single submitter
- DGKI p.Arg257His Uncertain significance Single submitter
- DGKI p.Arg258Gln Uncertain significance Single submitter
- DGKI p.Arg362His Uncertain significance Single submitter
- DGKI p.Arg692Gln Uncertain significance Single submitter
- DGKI p.Arg723Cys Uncertain significance Single submitter
- DGKI p.Arg909His Uncertain significance Single submitter
- DGKI p.Arg90Trp Uncertain significance Single submitter
- DGKI p.Asn1044Ser Uncertain significance Single submitter
- DGKI p.Asn525Asp Uncertain significance Single submitter
- DGKI p.Asn54Ile Uncertain significance Single submitter
- DGKI p.Asp115Glu Uncertain significance Single submitter
- DGKI p.Asp579Ala Uncertain significance Single submitter
- DGKI p.Asp792Glu Uncertain significance Single submitter
- DGKI p.Asp899Asn Uncertain significance Single submitter
- DGKI p.Asp901Gly Uncertain significance Single submitter
- DGKI p.Asp972Glu Uncertain significance Single submitter
- DGKI p.Cys80Ser Uncertain significance Single submitter
- DGKI p.Gln111His Uncertain significance Single submitter
- DGKI p.Gln653His Uncertain significance Single submitter
- DGKI p.Gln786His Uncertain significance Single submitter
- DGKI p.Glu162Lys Uncertain significance Single submitter
- DGKI p.Glu177Asp Uncertain significance Single submitter
- DGKI p.Glu260Lys Uncertain significance Single submitter
- DGKI p.Glu898Asp Uncertain significance Single submitter
- DGKI p.Gly110Asp Uncertain significance Single submitter
- DGKI p.Gly110Ser Uncertain significance Single submitter
- DGKI p.Gly110Val Uncertain significance Single submitter
- DGKI p.Gly18Ala Uncertain significance Single submitter
- DGKI p.Gly18Arg Uncertain significance Single submitter
- DGKI p.Gly64Arg Uncertain significance Single submitter
- DGKI p.Gly738Arg Uncertain significance Single submitter
- DGKI p.Gly77Arg Uncertain significance Single submitter
- DGKI p.Gly784Asp Uncertain significance Single submitter
- DGKI p.Gly7Val Uncertain significance Single submitter
- DGKI p.Gly91Asp Uncertain significance Single submitter
- DGKI p.Gly91Val Uncertain significance Single submitter
- DGKI p.His144Arg Uncertain significance Single submitter
- DGKI p.His255Gln Uncertain significance Single submitter
- DGKI p.Ile228Val Uncertain significance Single submitter
- DGKI p.Ile771Val Uncertain significance Single submitter
- DGKI p.Ile893Val Uncertain significance Single submitter
- DGKI p.Leu13Gln Uncertain significance Single submitter
- DGKI p.Leu593Arg Uncertain significance Single submitter
- DGKI p.Leu756Ile Uncertain significance Single submitter
- DGKI p.Leu885Gln Uncertain significance Single submitter
- DGKI p.Leu905Arg Uncertain significance Single submitter
- DGKI p.Lys112Arg Uncertain significance Single submitter
- DGKI p.Lys63Asn Uncertain significance Single submitter
- DGKI p.Met398Leu Uncertain significance Single submitter
- DGKI p.Met53Lys Uncertain significance Single submitter
- DGKI p.Met690Val Uncertain significance Single submitter
- DGKI p.Met849Thr Uncertain significance Single submitter
- DGKI p.Met981Val Uncertain significance Single submitter
- DGKI p.Pro36Ala Uncertain significance Single submitter
- DGKI p.Pro36His Uncertain significance Single submitter
- DGKI p.Pro44Ala Uncertain significance Single submitter
- DGKI p.Pro511Thr Uncertain significance Single submitter
- DGKI p.Pro717Ala Uncertain significance Single submitter
- DGKI p.Pro949Gln Uncertain significance Single submitter
- DGKI p.Ser32Asn Uncertain significance Single submitter
- DGKI p.Ser58Pro Uncertain significance Single submitter
- DGKI p.Ser69Gly Uncertain significance Single submitter
- DGKI p.Ser72Thr Uncertain significance Single submitter
- DGKI p.Ser785Phe Uncertain significance Single submitter
- DGKI p.Ser870Leu Uncertain significance Single submitter
- DGKI p.Thr183Asn Uncertain significance Single submitter
- DGKI p.Thr437Lys Uncertain significance Single submitter
- DGKI p.Thr645Ala Uncertain significance Single submitter
- DGKI p.Thr857Ala Uncertain significance Single submitter
- DGKI p.Tyr421Cys Uncertain significance Single submitter
- DGKI p.Tyr736Cys Uncertain significance Single submitter
- DGKI p.Val217Leu Uncertain significance Single submitter
- DGKI p.Val458Ile Uncertain significance Single submitter
- DGKI p.Val788Ile Uncertain significance Single submitter
- DGKI p.Val910Met Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- DGKI p.Ala687Thr Uncertain significance Single submitter
- DGKI p.Ala687Val Uncertain significance Single submitter
- DGKI p.Arg17His Uncertain significance Single submitter
- DGKI p.Arg21Cys Uncertain significance Single submitter
- DGKI p.Arg237Gln Uncertain significance Single submitter
- DGKI p.Arg665Gln Uncertain significance Single submitter
- DGKI p.Arg723Ser Uncertain significance Single submitter
- DGKI p.Arg727Gln Uncertain significance Single submitter
- DGKI p.Asn555Ser Uncertain significance Single submitter
- DGKI p.Glu514Lys Uncertain significance Single submitter
- DGKI p.His503Asp Uncertain significance Single submitter
- DGKI p.Met398Ile Uncertain significance Single submitter
- DGKI p.Met677Ile Uncertain significance Single submitter
- DGKI p.Met701Val Uncertain significance Single submitter
- DGKI p.Ser132Leu Uncertain significance Single submitter
- DGKI p.Ser70Asn Uncertain significance Single submitter
- DGKI p.Ser908Phe Uncertain significance Single submitter
- DGKI p.Val365Met Uncertain significance Single submitter
- DGKI p.Val757Leu Uncertain significance Single submitter
All DGKI variants
Likely benign 1
- p.Asp104Glu Single submitter
Uncertain significance 130
- p.Ala101Gly Single submitter ⚠
- p.Ala1037Thr Single submitter ⚠
- p.Ala107Val Single submitter ⚠
- p.Ala15Glu Single submitter ⚠
- p.Ala20Val Single submitter ⚠
- p.Ala220Thr Single submitter ⚠
- p.Ala28Gly Single submitter ⚠
- p.Ala47Val Single submitter ⚠
- p.Ala48Val Single submitter ⚠
- p.Ala4Glu Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Ala650Val Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Ala687Thr Single submitter ⚠
- p.Ala687Val Single submitter ⚠
- p.Ala689Ser Single submitter ⚠
- p.Ala92Ser Single submitter ⚠
- p.Arg1042Cys Single submitter ⚠
- p.Arg1042His Single submitter ⚠
- p.Arg1042Ser Single submitter
- p.Arg164Thr Single submitter ⚠
- p.Arg17His Single submitter ⚠
- p.Arg21Cys Single submitter ⚠
- p.Arg237Gln Single submitter ⚠
- p.Arg257Cys Single submitter ⚠
- p.Arg257His Single submitter ⚠
- p.Arg258Gln Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg665Gln Single submitter ⚠
- p.Arg692Gln Single submitter ⚠
- p.Arg723Cys Single submitter ⚠
- p.Arg723Ser Single submitter ⚠
- p.Arg727Gln Single submitter ⚠
- p.Arg759His Single submitter
- p.Arg773Cys Single submitter
- p.Arg809Trp Single submitter
- p.Arg909His Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Asn1044Ser Single submitter ⚠
- p.Asn525Asp Single submitter ⚠
- p.Asn54Ile Single submitter ⚠
- p.Asn555Ser Single submitter ⚠
- p.Asp115Glu Single submitter ⚠
- p.Asp579Ala Single submitter ⚠
- p.Asp792Glu Single submitter ⚠
- p.Asp848His Single submitter
- p.Asp887Glu Single submitter
- p.Asp899Asn Single submitter ⚠
- p.Asp901Gly Single submitter ⚠
- p.Asp972fs Single submitter
- p.Asp972Glu Single submitter ⚠
- p.Cys80Ser Single submitter ⚠
- p.Gln111His Single submitter ⚠
- p.Gln653His Single submitter ⚠
- p.Gln786His Single submitter ⚠
- p.Glu162Lys Single submitter ⚠
- p.Glu177Asp Single submitter ⚠
- p.Glu260Lys Single submitter ⚠
- p.Glu514Lys Single submitter ⚠
- p.Glu898Asp Single submitter ⚠
- p.Gly110Asp Single submitter ⚠
- p.Gly110Ser Single submitter ⚠
- p.Gly110Val Single submitter ⚠
- p.Gly18Ala Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.Gly64Arg Single submitter ⚠
- p.Gly738Arg Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.Gly784Asp Single submitter ⚠
- p.Gly7Val Single submitter ⚠
- p.Gly91Asp Single submitter ⚠
- p.Gly91Val Single submitter ⚠
- p.Gly964Arg Single submitter
- p.Gly987Ser Single submitter
- p.His144Arg Single submitter ⚠
- p.His255Gln Single submitter ⚠
- p.His503Asp Single submitter ⚠
- p.His956Tyr Single submitter
- p.Ile228Val Single submitter ⚠
- p.Ile771Val Single submitter ⚠
- p.Ile893Val Single submitter ⚠
- p.Leu13Gln Single submitter ⚠
- p.Leu593Arg Single submitter ⚠
- p.Leu756Ile Single submitter ⚠
- p.Leu885Gln Single submitter ⚠
- p.Leu890fs Single submitter
- p.Leu905Arg Single submitter ⚠
- p.Leu954Pro Single submitter
- p.Lys112Arg Single submitter ⚠
- p.Lys63Asn Single submitter ⚠
- p.Met398Ile Single submitter ⚠
- p.Met398Leu Single submitter ⚠
- p.Met53Lys Single submitter ⚠
- p.Met677Ile Single submitter ⚠
- p.Met690Val Single submitter ⚠
- p.Met701Val Single submitter ⚠
- p.Met849Thr Single submitter ⚠
- p.Met981Val Single submitter ⚠
- p.Phe843Ser Single submitter
- p.Pro33fs Single submitter
- p.Pro36Ala Single submitter ⚠
- p.Pro36His Single submitter ⚠
- p.Pro44Ala Single submitter ⚠
- p.Pro511Thr Single submitter ⚠
- p.Pro717Ala Single submitter ⚠
- p.Pro808Leu Single submitter
- p.Pro949Gln Single submitter ⚠
- p.Ser132Leu Single submitter ⚠
- p.Ser241Ter Single submitter
- p.Ser32Asn Single submitter ⚠
- p.Ser58Pro Single submitter ⚠
- p.Ser69Gly Single submitter ⚠
- p.Ser70Asn Single submitter ⚠
- p.Ser72Thr Single submitter ⚠
- p.Ser785Phe Single submitter ⚠
- p.Ser870Leu Single submitter ⚠
- p.Ser908Phe Single submitter ⚠
- p.Thr183Asn Single submitter ⚠
- p.Thr437Lys Single submitter ⚠
- p.Thr645Ala Single submitter ⚠
- p.Thr857Ala Single submitter ⚠
- p.Tyr421Cys Single submitter ⚠
- p.Tyr736Cys Single submitter ⚠
- p.Val217Leu Single submitter ⚠
- p.Val365Met Single submitter ⚠
- p.Val458Ile Single submitter ⚠
- p.Val757Ile Single submitter
- p.Val757Leu Single submitter ⚠
- p.Val788Ile Single submitter ⚠
- p.Val910Met Single submitter ⚠