DGKK — 117 ClinVar variants
All ClinVar germline DGKK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
9 Benign · 13 Likely benign · 95 Uncertain significance
Full DGKK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 82
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DGKK p.Ala102Thr Uncertain significance Single submitter
- DGKK p.Ala1145Val Uncertain significance Single submitter
- DGKK p.Ala252Thr Uncertain significance Single submitter
- DGKK p.Ala540Val Uncertain significance Single submitter
- DGKK p.Ala8Thr Uncertain significance Single submitter
- DGKK p.Arg174His Uncertain significance Single submitter
- DGKK p.Arg206Gly Uncertain significance Single submitter
- DGKK p.Arg285Gln Uncertain significance Single submitter
- DGKK p.Arg442Lys Uncertain significance Single submitter
- DGKK p.Arg541Cys Uncertain significance Single submitter
- DGKK p.Arg541His Uncertain significance Single submitter
- DGKK p.Arg713Gly Uncertain significance Single submitter
- DGKK p.Arg817Cys Uncertain significance Single submitter
- DGKK p.Arg877Lys Uncertain significance Single submitter
- DGKK p.Arg888Cys Uncertain significance Single submitter
- DGKK p.Arg906His Uncertain significance Single submitter
- DGKK p.Arg981His Uncertain significance Single submitter
- DGKK p.Arg981Leu Uncertain significance Single submitter
- DGKK p.Arg989Cys Uncertain significance Single submitter
- DGKK p.Asn696Lys Uncertain significance Single submitter
- DGKK p.Asn839Thr Uncertain significance Single submitter
- DGKK p.Asp2His Uncertain significance Single submitter
- DGKK p.Asp719Asn Uncertain significance Single submitter
- DGKK p.Asp805Asn Uncertain significance Single submitter
- DGKK p.Asp809Val Uncertain significance Single submitter
- DGKK p.Cys166Tyr Uncertain significance Single submitter
- DGKK p.Cys547Trp Uncertain significance Single submitter
- DGKK p.Gln309Lys Uncertain significance Single submitter
- DGKK p.Gln9Arg Uncertain significance Single submitter
- DGKK p.Glu311Gly Uncertain significance Single submitter
- DGKK p.Glu417Lys Uncertain significance Single submitter
- DGKK p.Glu48Gln Uncertain significance Single submitter
- DGKK p.Glu80Gly Uncertain significance Single submitter
- DGKK p.Glu833Asp Uncertain significance Single submitter
- DGKK p.Gly1154Cys Uncertain significance Single submitter
- DGKK p.Gly1225Arg Uncertain significance Single submitter
- DGKK p.Gly579Ser Uncertain significance Single submitter
- DGKK p.His416Leu Uncertain significance Single submitter
- DGKK p.His503Tyr Uncertain significance Single submitter
- DGKK p.His648Asn Uncertain significance Single submitter
- DGKK p.Ile214Val Uncertain significance Single submitter
- DGKK p.Ile312Val Uncertain significance Single submitter
- DGKK p.Ile752Val Uncertain significance Single submitter
- DGKK p.Ile850Leu Uncertain significance Single submitter
- DGKK p.Ile924Val Uncertain significance Single submitter
- DGKK p.Ile937Val Uncertain significance Single submitter
- DGKK p.Ile961Met Uncertain significance Single submitter
- DGKK p.Leu218Phe Uncertain significance Single submitter
- DGKK p.Lys795Arg Uncertain significance Single submitter
- DGKK p.Phe797Tyr Uncertain significance Single submitter
- DGKK p.Pro1222Ser Uncertain significance Single submitter
- DGKK p.Pro125Leu Uncertain significance Single submitter
- DGKK p.Pro137Leu Uncertain significance Single submitter
- DGKK p.Pro171Ser Uncertain significance Single submitter
- DGKK p.Pro177Ser Uncertain significance Single submitter
- DGKK p.Pro20Leu Uncertain significance Single submitter
- DGKK p.Pro283Leu Uncertain significance Single submitter
- DGKK p.Pro28Leu Uncertain significance Single submitter
- DGKK p.Pro32Gln Uncertain significance Single submitter
- DGKK p.Pro37Gln Uncertain significance Single submitter
- DGKK p.Pro51Leu Uncertain significance Single submitter
- DGKK p.Pro639Leu Uncertain significance Single submitter
- DGKK p.Pro747His Uncertain significance Single submitter
- DGKK p.Pro847Leu Uncertain significance Single submitter
- DGKK p.Pro93Leu Uncertain significance Single submitter
- DGKK p.Ser133Thr Uncertain significance Single submitter
- DGKK p.Ser196Leu Uncertain significance Single submitter
- DGKK p.Ser23Phe Uncertain significance Single submitter
- DGKK p.Ser50Leu Uncertain significance Single submitter
- DGKK p.Ser729Thr Uncertain significance Single submitter
- DGKK p.Ser798Asn Uncertain significance Single submitter
- DGKK p.Ser828Thr Uncertain significance Single submitter
- DGKK p.Thr154Ser Uncertain significance Single submitter
- DGKK p.Thr623Ile Uncertain significance Single submitter
- DGKK p.Thr900Ala Uncertain significance Single submitter
- DGKK p.Trp432Arg Uncertain significance Single submitter
- DGKK p.Val240Ile Uncertain significance Single submitter
- DGKK p.Val280Ile Uncertain significance Single submitter
- DGKK p.Val437Met Uncertain significance Single submitter
- DGKK p.Val474Ile Uncertain significance Single submitter
- DGKK p.Val610Met Uncertain significance Single submitter
- DGKK p.Val975Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- DGKK p.Pro125Thr Uncertain significance Multiple submitters
- DGKK p.Ala373Gly Uncertain significance Single submitter
- DGKK p.Arg673Ser Uncertain significance Single submitter
- DGKK p.Arg906Cys Uncertain significance Single submitter
- DGKK p.Glu104Lys Uncertain significance Single submitter
- DGKK p.Gly326Arg Uncertain significance Single submitter
- DGKK p.Phe522Leu Uncertain significance Single submitter
- DGKK p.Pro103Gln Uncertain significance Single submitter
- DGKK p.Pro39Arg Uncertain significance Single submitter
- DGKK p.Ser277Arg Uncertain significance Single submitter
All DGKK variants
Benign 9
- c.3112-10T>C Multiple submitters
- p.Ala106Val Multiple submitters
- p.Arg851Cys Multiple submitters
- p.Asp708= Multiple submitters
- p.Ile612Asn Multiple submitters
- p.Pro83= Multiple submitters
- p.Ser1069Asn Multiple submitters
- p.37PAPP[1] Single submitter
- p.Pro1203Ser Single submitter
Likely benign 13
- c.3737-17dup Single submitter
- p.196SP[6] Single submitter
- p.Ala102= Single submitter
- p.Ala730Val Single submitter
- p.Glu140= Single submitter
- p.Gly505= Single submitter
- p.Ile303Val Single submitter
- p.Ile864= Single submitter
- p.Pro101= Single submitter
- p.Pro29= Single submitter
- p.Ser1208= Single submitter
- p.Thr654= Single submitter
- p.Val507Ile Single submitter
Uncertain significance 95
- p.Pro125Thr Multiple submitters ⚠
- p.Ala102Thr Single submitter ⚠
- p.Ala1145Val Single submitter ⚠
- p.Ala252Thr Single submitter ⚠
- p.Ala373Gly Single submitter ⚠
- p.Ala540Val Single submitter ⚠
- p.Ala8Thr Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg206Gly Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg442Lys Single submitter ⚠
- p.Arg541Cys Single submitter ⚠
- p.Arg541His Single submitter ⚠
- p.Arg584His Single submitter
- p.Arg673Ser Single submitter ⚠
- p.Arg713Gly Single submitter ⚠
- p.Arg817Cys Single submitter ⚠
- p.Arg877Lys Single submitter ⚠
- p.Arg888Cys Single submitter ⚠
- p.Arg906Cys Single submitter ⚠
- p.Arg906His Single submitter ⚠
- p.Arg981His Single submitter ⚠
- p.Arg981Leu Single submitter ⚠
- p.Arg989Cys Single submitter ⚠
- p.Asn696Lys Single submitter ⚠
- p.Asn839Thr Single submitter ⚠
- p.Asp2His Single submitter ⚠
- p.Asp719Asn Single submitter ⚠
- p.Asp805Asn Single submitter ⚠
- p.Asp809Val Single submitter ⚠
- p.Cys166Tyr Single submitter ⚠
- p.Cys547Trp Single submitter ⚠
- p.Gln309Lys Single submitter ⚠
- p.Gln9Arg Single submitter ⚠
- p.Glu104Lys Single submitter ⚠
- p.Glu311Gly Single submitter ⚠
- p.Glu417Lys Single submitter ⚠
- p.Glu48Gln Single submitter ⚠
- p.Glu80Gly Single submitter ⚠
- p.Glu833Asp Single submitter ⚠
- p.Gly1154Cys Single submitter ⚠
- p.Gly1225Arg Single submitter ⚠
- p.Gly326Arg Single submitter ⚠
- p.Gly579Ser Single submitter ⚠
- p.His416Leu Single submitter ⚠
- p.His503Tyr Single submitter ⚠
- p.His648Asn Single submitter ⚠
- p.Ile214Val Single submitter ⚠
- p.Ile312Val Single submitter ⚠
- p.Ile752Val Single submitter ⚠
- p.Ile850Leu Single submitter ⚠
- p.Ile924Val Single submitter ⚠
- p.Ile937Val Single submitter ⚠
- p.Ile961Met Single submitter ⚠
- p.Leu218Phe Single submitter ⚠
- p.Lys795Arg Single submitter ⚠
- p.Lys901Gln Single submitter
- p.Phe522Leu Single submitter ⚠
- p.Phe797Tyr Single submitter ⚠
- p.Pro103Gln Single submitter ⚠
- p.Pro1222Ser Single submitter ⚠
- p.Pro125Leu Single submitter ⚠
- p.Pro137Leu Single submitter ⚠
- p.Pro171Ser Single submitter ⚠
- p.Pro177Ser Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro32Gln Single submitter ⚠
- p.Pro37Gln Single submitter ⚠
- p.Pro39Arg Single submitter ⚠
- p.Pro51Leu Single submitter ⚠
- p.Pro639Leu Single submitter ⚠
- p.Pro747His Single submitter ⚠
- p.Pro847Leu Single submitter ⚠
- p.Pro93Leu Single submitter ⚠
- p.Ser133Thr Single submitter ⚠
- p.Ser196Leu Single submitter ⚠
- p.Ser23Phe Single submitter ⚠
- p.Ser277Arg Single submitter ⚠
- p.Ser50Leu Single submitter ⚠
- p.Ser729Thr Single submitter ⚠
- p.Ser798Asn Single submitter ⚠
- p.Ser828Thr Single submitter ⚠
- p.Thr154Ser Single submitter ⚠
- p.Thr623Ile Single submitter ⚠
- p.Thr900Ala Single submitter ⚠
- p.Trp432Arg Single submitter ⚠
- p.Val240Ile Single submitter ⚠
- p.Val280Ile Single submitter ⚠
- p.Val437Met Single submitter ⚠
- p.Val474Ile Single submitter ⚠
- p.Val553Met Single submitter
- p.Val610Met Single submitter ⚠
- p.Val975Ala Single submitter ⚠