DHDH — 65 ClinVar variants
All ClinVar germline DHDH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
3 Likely benign · 62 Uncertain significance
Full DHDH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHDH p.Ala89Val Uncertain significance Single submitter
- DHDH p.Arg26Pro Uncertain significance Single submitter
- DHDH p.Arg334Cys Uncertain significance Single submitter
- DHDH p.Asp38Ala Uncertain significance Single submitter
- DHDH p.Cys181Tyr Uncertain significance Single submitter
- DHDH p.Cys253Tyr Uncertain significance Single submitter
- DHDH p.Cys295Phe Uncertain significance Single submitter
- DHDH p.Cys95Ser Uncertain significance Single submitter
- DHDH p.Cys95Tyr Uncertain significance Single submitter
- DHDH p.Gln183His Uncertain significance Single submitter
- DHDH p.Glu258Lys Uncertain significance Single submitter
- DHDH p.Gly171Arg Uncertain significance Single submitter
- DHDH p.Gly171Trp Uncertain significance Single submitter
- DHDH p.His29Tyr Uncertain significance Single submitter
- DHDH p.His79Asp Uncertain significance Single submitter
- DHDH p.Ile124Val Uncertain significance Single submitter
- DHDH p.Ile177Val Uncertain significance Single submitter
- DHDH p.Ile197Ser Uncertain significance Single submitter
- DHDH p.Lys63Glu Uncertain significance Single submitter
- DHDH p.Lys91Gln Uncertain significance Single submitter
- DHDH p.Phe129Val Uncertain significance Single submitter
- DHDH p.Pro272Leu Uncertain significance Single submitter
- DHDH p.Ser198Thr Uncertain significance Single submitter
- DHDH p.Ser311Arg Uncertain significance Single submitter
- DHDH p.Val182Asp Uncertain significance Single submitter
-
DHDH p.His204Leu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 38
The independent predictors disagree with each other — read with care.
- DHDH p.Ala111Ser Uncertain significance Single submitter
- DHDH p.Ala134Thr Uncertain significance Single submitter
- DHDH p.Ala173Thr Uncertain significance Single submitter
- DHDH p.Ala70Ser Uncertain significance Single submitter
- DHDH p.Arg107His Uncertain significance Single submitter
- DHDH p.Arg107Ser Uncertain significance Single submitter
- DHDH p.Arg127His Uncertain significance Single submitter
- DHDH p.Arg136Lys Uncertain significance Single submitter
- DHDH p.Arg163Gln Uncertain significance Single submitter
- DHDH p.Arg167Trp Likely benign Single submitter
- DHDH p.Arg297Gly Uncertain significance Single submitter
- DHDH p.Asn157Tyr Uncertain significance Single submitter
- DHDH p.Asn278Asp Uncertain significance Single submitter
- DHDH p.Cys255Gly Uncertain significance Single submitter
- DHDH p.Cys255Tyr Uncertain significance Single submitter
- DHDH p.Gln78Arg Uncertain significance Single submitter
- DHDH p.Glu112Asp Uncertain significance Single submitter
- DHDH p.Glu195Gln Uncertain significance Single submitter
- DHDH p.Gly11Ser Uncertain significance Single submitter
- DHDH p.Gly56Ser Uncertain significance Single submitter
- DHDH p.His223Arg Uncertain significance Single submitter
- DHDH p.Ile317Thr Uncertain significance Single submitter
- DHDH p.Pro269Gln Uncertain significance Single submitter
- DHDH p.Pro269Leu Likely benign Single submitter
- DHDH p.Pro271Ser Uncertain significance Single submitter
- DHDH p.Ser229Asn Uncertain significance Single submitter
- DHDH p.Ser309Leu Uncertain significance Single submitter
- DHDH p.Ser309Pro Uncertain significance Single submitter
- DHDH p.Ser311Cys Uncertain significance Single submitter
- DHDH p.Ser40Thr Uncertain significance Single submitter
- DHDH p.Ser66Arg Uncertain significance Single submitter
- DHDH p.Thr99Lys Uncertain significance Single submitter
- DHDH p.Val161Asp Uncertain significance Single submitter
- DHDH p.Val208Met Uncertain significance Single submitter
- DHDH p.Val232Met Uncertain significance Single submitter
- DHDH p.Val240Met Uncertain significance Single submitter
- DHDH p.Val292Ile Uncertain significance Single submitter
- DHDH p.Val67Leu Uncertain significance Single submitter
All DHDH variants
Likely benign 3
- p.Arg167Trp Single submitter ⚠
- p.Pro269Leu Single submitter ⚠
- p.Thr99Met Single submitter
Uncertain significance 62
- p.Ala111Ser Single submitter ⚠
- p.Ala134Thr Single submitter ⚠
- p.Ala173Thr Single submitter ⚠
- p.Ala70Ser Single submitter ⚠
- p.Ala89Val Single submitter ⚠
- p.Arg107His Single submitter ⚠
- p.Arg107Ser Single submitter ⚠
- p.Arg127His Single submitter ⚠
- p.Arg136Lys Single submitter ⚠
- p.Arg163Gln Single submitter ⚠
- p.Arg26Pro Single submitter ⚠
- p.Arg297Gly Single submitter ⚠
- p.Arg334Cys Single submitter ⚠
- p.Asn157Tyr Single submitter ⚠
- p.Asn278Asp Single submitter ⚠
- p.Asp38Ala Single submitter ⚠
- p.Cys181Tyr Single submitter ⚠
- p.Cys253Tyr Single submitter ⚠
- p.Cys255Gly Single submitter ⚠
- p.Cys255Tyr Single submitter ⚠
- p.Cys295Phe Single submitter ⚠
- p.Cys95Ser Single submitter ⚠
- p.Cys95Tyr Single submitter ⚠
- p.Gln183His Single submitter ⚠
- p.Gln78Arg Single submitter ⚠
- p.Glu112Asp Single submitter ⚠
- p.Glu195Gln Single submitter ⚠
- p.Glu258Lys Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Gly171Arg Single submitter ⚠
- p.Gly171Trp Single submitter ⚠
- p.Gly56Ser Single submitter ⚠
- p.His223Arg Single submitter ⚠
- p.His29Tyr Single submitter ⚠
- p.His79Asp Single submitter ⚠
- p.Ile124Val Single submitter ⚠
- p.Ile177Val Single submitter ⚠
- p.Ile197Ser Single submitter ⚠
- p.Ile317Thr Single submitter ⚠
- p.Lys63Glu Single submitter ⚠
- p.Lys91Gln Single submitter ⚠
- p.Phe129Val Single submitter ⚠
- p.Pro269Gln Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro272Leu Single submitter ⚠
- p.Ser198Thr Single submitter ⚠
- p.Ser229Asn Single submitter ⚠
- p.Ser309Leu Single submitter ⚠
- p.Ser309Pro Single submitter ⚠
- p.Ser311Arg Single submitter ⚠
- p.Ser311Cys Single submitter ⚠
- p.Ser40Thr Single submitter ⚠
- p.Ser66Arg Single submitter ⚠
- p.Thr99Lys Single submitter ⚠
- p.Val161Asp Single submitter ⚠
- p.Val182Asp Single submitter ⚠
- p.Val208Met Single submitter ⚠
- p.Val232Met Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val292Ile Single submitter ⚠
- p.Val67Leu Single submitter ⚠
- p.His204Leu No assertion criteria prostate cancer ⚠