DHRS1 — 51 ClinVar variants
All ClinVar germline DHRS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Likely benign · 48 Uncertain significance
Full DHRS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHRS1 p.Ala169Val Uncertain significance Single submitter
- DHRS1 p.Ala175Pro Uncertain significance Single submitter
- DHRS1 p.Ala32Val Uncertain significance Single submitter
- DHRS1 p.Arg104Ser Uncertain significance Single submitter
- DHRS1 p.Arg183His Uncertain significance Single submitter
- DHRS1 p.Arg21Cys Uncertain significance Single submitter
- DHRS1 p.Arg21His Uncertain significance Single submitter
- DHRS1 p.Arg300His Uncertain significance Single submitter
- DHRS1 p.Arg80Gln Uncertain significance Single submitter
- DHRS1 p.Asn160Ser Uncertain significance Single submitter
- DHRS1 p.Cys177Arg Uncertain significance Single submitter
- DHRS1 p.Cys63Gly Uncertain significance Single submitter
- DHRS1 p.Gln218Glu Uncertain significance Single submitter
- DHRS1 p.Gln67Arg Uncertain significance Single submitter
- DHRS1 p.Glu180Lys Uncertain significance Single submitter
- DHRS1 p.Glu209Val Uncertain significance Single submitter
- DHRS1 p.Gly123Arg Uncertain significance Single submitter
- DHRS1 p.Gly14Asp Uncertain significance Single submitter
- DHRS1 p.His204Asp Uncertain significance Single submitter
- DHRS1 p.His284Asn Uncertain significance Single submitter
- DHRS1 p.Ile119Asn Uncertain significance Single submitter
- DHRS1 p.Leu276Phe Uncertain significance Single submitter
- DHRS1 p.Leu278Val Uncertain significance Single submitter
- DHRS1 p.Leu44Phe Uncertain significance Single submitter
- DHRS1 p.Leu89Pro Uncertain significance Single submitter
- DHRS1 p.Met115Val Uncertain significance Single submitter
- DHRS1 p.Pro193Leu Uncertain significance Single submitter
- DHRS1 p.Pro302Leu Uncertain significance Single submitter
- DHRS1 p.Ser154Ile Uncertain significance Single submitter
- DHRS1 p.Ser69Asn Uncertain significance Single submitter
- DHRS1 p.Thr99Met Uncertain significance Single submitter
- DHRS1 p.Tyr262Cys Uncertain significance Single submitter
- DHRS1 p.Val161Ile Uncertain significance Single submitter
- DHRS1 p.Val272Ile Uncertain significance Single submitter
- DHRS1 p.Val61Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- DHRS1 p.Ala32Ser Uncertain significance Single submitter
- DHRS1 p.Arg265Trp Uncertain significance Single submitter
- DHRS1 p.Arg270Cys Uncertain significance Single submitter
- DHRS1 p.Arg80Trp Uncertain significance Single submitter
- DHRS1 p.Asn160Asp Uncertain significance Single submitter
- DHRS1 p.Cys188Tyr Likely benign Single submitter
- DHRS1 p.Glu203Lys Uncertain significance Single submitter
- DHRS1 p.Gly185Arg Uncertain significance Single submitter
- DHRS1 p.Ile19Val Uncertain significance Single submitter
- DHRS1 p.Leu200Arg Uncertain significance Single submitter
- DHRS1 p.Ser187Arg Uncertain significance Single submitter
All DHRS1 variants
Likely benign 3
- p.Arg72Gln Single submitter
- p.Cys188Tyr Single submitter ⚠
- p.Thr99Ala Single submitter
Uncertain significance 48
- p.Ala169Val Single submitter ⚠
- p.Ala175Pro Single submitter ⚠
- p.Ala32Ser Single submitter ⚠
- p.Ala32Val Single submitter ⚠
- p.Arg104Ser Single submitter ⚠
- p.Arg183His Single submitter ⚠
- p.Arg21Cys Single submitter ⚠
- p.Arg21His Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg270Cys Single submitter ⚠
- p.Arg300His Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asn160Asp Single submitter ⚠
- p.Asn160Ser Single submitter ⚠
- p.Asp257Glu Single submitter
- p.Cys177Arg Single submitter ⚠
- p.Cys63Gly Single submitter ⚠
- p.Gln218Glu Single submitter ⚠
- p.Gln67Arg Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu209Val Single submitter ⚠
- p.Gly123Arg Single submitter ⚠
- p.Gly14Asp Single submitter ⚠
- p.Gly185Arg Single submitter ⚠
- p.His204Asp Single submitter ⚠
- p.His284Asn Single submitter ⚠
- p.Ile119Asn Single submitter ⚠
- p.Ile19Val Single submitter ⚠
- p.Ile305Thr Single submitter
- p.Leu200Arg Single submitter ⚠
- p.Leu276Phe Single submitter ⚠
- p.Leu278Val Single submitter ⚠
- p.Leu44Phe Single submitter ⚠
- p.Leu89Pro Single submitter ⚠
- p.Lys312Glu Single submitter
- p.Met115Val Single submitter ⚠
- p.Pro193Leu Single submitter ⚠
- p.Pro302Leu Single submitter ⚠
- p.Ser154Ile Single submitter ⚠
- p.Ser187Arg Single submitter ⚠
- p.Ser69Asn Single submitter ⚠
- p.Thr99Met Single submitter ⚠
- p.Tyr262Cys Single submitter ⚠
- p.Val161Ile Single submitter ⚠
- p.Val272Ile Single submitter ⚠
- p.Val61Ala Single submitter ⚠