DHRS11 — 39 ClinVar variants
All ClinVar germline DHRS11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
39 Uncertain significance
Full DHRS11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHRS11 p.Ala124Asp Uncertain significance Single submitter
- DHRS11 p.Ala218Pro Uncertain significance Single submitter
- DHRS11 p.Ala244Glu Uncertain significance Single submitter
- DHRS11 p.Ala244Thr Uncertain significance Single submitter
- DHRS11 p.Arg12Gly Uncertain significance Single submitter
- DHRS11 p.Arg130Trp Uncertain significance Single submitter
- DHRS11 p.Arg43Leu Uncertain significance Single submitter
- DHRS11 p.Gly109Asp Uncertain significance Single submitter
- DHRS11 p.Gly154Ala Uncertain significance Single submitter
- DHRS11 p.Gly22Asp Uncertain significance Single submitter
- DHRS11 p.Gly90Asp Uncertain significance Single submitter
- DHRS11 p.Ile237Thr Uncertain significance Single submitter
- DHRS11 p.Leu158Ile Uncertain significance Single submitter
- DHRS11 p.Leu51Val Uncertain significance Single submitter
- DHRS11 p.Lys208Arg Uncertain significance Single submitter
- DHRS11 p.Thr17Met Uncertain significance Single submitter
- DHRS11 p.Trp9Arg Uncertain significance Single submitter
- DHRS11 p.Val157Gly Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- DHRS11 p.Ala206Thr Uncertain significance Single submitter
- DHRS11 p.Ala233Thr Uncertain significance Single submitter
- DHRS11 p.Ala2Gly Uncertain significance Single submitter
- DHRS11 p.Arg102Trp Uncertain significance Single submitter
- DHRS11 p.Arg185Gln Uncertain significance Single submitter
- DHRS11 p.Arg192Gln Uncertain significance Single submitter
- DHRS11 p.Arg8Gln Uncertain significance Single submitter
- DHRS11 p.Gln33His Uncertain significance Single submitter
- DHRS11 p.Glu74Gly Uncertain significance Single submitter
- DHRS11 p.Gly46Asp Uncertain significance Single submitter
- DHRS11 p.Gly5Arg Uncertain significance Single submitter
- DHRS11 p.Gly5Val Uncertain significance Single submitter
- DHRS11 p.Ile127Val Uncertain significance Single submitter
- DHRS11 p.Ile191Val Uncertain significance Single submitter
- DHRS11 p.Leu78Phe Uncertain significance Single submitter
- DHRS11 p.Met80Val Uncertain significance Single submitter
- DHRS11 p.Ser126Gly Uncertain significance Single submitter
- DHRS11 p.Ser161Phe Uncertain significance Single submitter
- DHRS11 p.Ser241Asn Uncertain significance Single submitter
- DHRS11 p.Thr111Asn Uncertain significance Single submitter
- DHRS11 p.Val173Ile Uncertain significance Single submitter
All DHRS11 variants
Uncertain significance 39
- p.Ala124Asp Single submitter ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala218Pro Single submitter ⚠
- p.Ala233Thr Single submitter ⚠
- p.Ala244Glu Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg12Gly Single submitter ⚠
- p.Arg130Trp Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg43Leu Single submitter ⚠
- p.Arg8Gln Single submitter ⚠
- p.Gln33His Single submitter ⚠
- p.Glu74Gly Single submitter ⚠
- p.Gly109Asp Single submitter ⚠
- p.Gly154Ala Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly46Asp Single submitter ⚠
- p.Gly5Arg Single submitter ⚠
- p.Gly5Val Single submitter ⚠
- p.Gly90Asp Single submitter ⚠
- p.Ile127Val Single submitter ⚠
- p.Ile191Val Single submitter ⚠
- p.Ile237Thr Single submitter ⚠
- p.Leu158Ile Single submitter ⚠
- p.Leu51Val Single submitter ⚠
- p.Leu78Phe Single submitter ⚠
- p.Lys208Arg Single submitter ⚠
- p.Met80Val Single submitter ⚠
- p.Ser126Gly Single submitter ⚠
- p.Ser161Phe Single submitter ⚠
- p.Ser241Asn Single submitter ⚠
- p.Thr111Asn Single submitter ⚠
- p.Thr17Met Single submitter ⚠
- p.Trp9Arg Single submitter ⚠
- p.Val157Gly Single submitter ⚠
- p.Val173Ile Single submitter ⚠