DHRS2 — 76 ClinVar variants
All ClinVar germline DHRS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
4 Benign · 1 Benign/Likely benign · 13 Likely benign · 58 Uncertain significance
Full DHRS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHRS2 p.Ala17Gly Uncertain significance Single submitter
- DHRS2 p.Ala61Asp Uncertain significance Single submitter
- DHRS2 p.Ala78Thr Uncertain significance Single submitter
- DHRS2 p.Arg75Gln Uncertain significance Single submitter
- DHRS2 p.Asn145Lys Uncertain significance Single submitter
- DHRS2 p.Cys119Arg Uncertain significance Single submitter
- DHRS2 p.Cys92Ser Uncertain significance Single submitter
- DHRS2 p.Gly11Ser Uncertain significance Single submitter
- DHRS2 p.Gly165Ser Uncertain significance Single submitter
- DHRS2 p.Gly183Ala Uncertain significance Single submitter
- DHRS2 p.Gly183Val Uncertain significance Single submitter
- DHRS2 p.Gly194Val Uncertain significance Single submitter
- DHRS2 p.Gly246Val Uncertain significance Single submitter
- DHRS2 p.Gly268Glu Uncertain significance Single submitter
- DHRS2 p.Gly275Asp Uncertain significance Single submitter
- DHRS2 p.Ile217Met Uncertain significance Single submitter
- DHRS2 p.Met77Thr Uncertain significance Single submitter
- DHRS2 p.Pro15His Uncertain significance Single submitter
- DHRS2 p.Ser154Arg Uncertain significance Single submitter
- DHRS2 p.Ser188Arg Uncertain significance Single submitter
- DHRS2 p.Tyr276Cys Uncertain significance Single submitter
- DHRS2 p.Val127Leu Uncertain significance Single submitter
- DHRS2 p.Val180Glu Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- DHRS2 p.Arg7Trp Likely benign Multiple submitters
- DHRS2 p.Gly84Arg Likely benign Multiple submitters
- DHRS2 p.Ala263Thr Uncertain significance Single submitter
- DHRS2 p.Ala272Glu Likely benign Single submitter
- DHRS2 p.Ala51Val Uncertain significance Single submitter
- DHRS2 p.Arg100Gln Uncertain significance Single submitter
- DHRS2 p.Arg279Trp Likely benign Single submitter
- DHRS2 p.Arg55Cys Uncertain significance Single submitter
- DHRS2 p.Arg68Trp Uncertain significance Single submitter
- DHRS2 p.Arg75Trp Uncertain significance Single submitter
- DHRS2 p.Asn124Ser Uncertain significance Single submitter
- DHRS2 p.Gln81Glu Uncertain significance Single submitter
- DHRS2 p.Glu249Gly Uncertain significance Single submitter
- DHRS2 p.Gly122Arg Uncertain significance Single submitter
- DHRS2 p.Gly165Val Uncertain significance Single submitter
- DHRS2 p.Gly27Arg Uncertain significance Single submitter
- DHRS2 p.His227Arg Uncertain significance Single submitter
- DHRS2 p.His62Tyr Uncertain significance Single submitter
- DHRS2 p.Ile245Thr Likely benign Single submitter
- DHRS2 p.Ile52Val Uncertain significance Single submitter
- DHRS2 p.Leu34Pro Uncertain significance Single submitter
- DHRS2 p.Leu85Met Uncertain significance Single submitter
- DHRS2 p.Phe13Leu Uncertain significance Single submitter
- DHRS2 p.Ser129Arg Uncertain significance Single submitter
- DHRS2 p.Ser25Asn Uncertain significance Single submitter
- DHRS2 p.Thr196Ser Uncertain significance Single submitter
- DHRS2 p.Tyr176Cys Uncertain significance Single submitter
- DHRS2 p.Val104Met Uncertain significance Single submitter
- DHRS2 p.Val167Ala Uncertain significance Single submitter
- DHRS2 p.Val40Met Uncertain significance Single submitter
- DHRS2 p.Val73Met Uncertain significance Single submitter
All DHRS2 variants
Benign 4
- p.Cys92= Multiple submitters
- p.Arg30Gly Single submitter
- p.Asp59= Single submitter
- p.Thr26= Single submitter
Benign/Likely benign 1
- p.Arg279= Multiple submitters
Likely benign 13
- p.Arg7Trp Multiple submitters ⚠
- p.Gly84Arg Multiple submitters ⚠
- p.Ala272= Single submitter
- p.Ala272Glu Single submitter ⚠
- p.Ala272Val Single submitter
- p.Arg279Trp Single submitter ⚠
- p.Arg54Gln Single submitter
- p.Gly275Ser Single submitter
- p.Ile245Thr Single submitter ⚠
- p.Ile254= Single submitter
- p.Leu232Phe Single submitter
- p.Ser231Pro Single submitter
- p.Val266Ile Single submitter
Uncertain significance 58
- c.*2A>T Single submitter
- c.*3G>A Single submitter
- c.*42G>A Single submitter
- p.Ala17Gly Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala274= Single submitter
- p.Ala51Val Single submitter ⚠
- p.Ala61Asp Single submitter ⚠
- p.Ala78Thr Single submitter ⚠
- p.Arg100Gln Single submitter ⚠
- p.Arg55Cys Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Arg75Trp Single submitter ⚠
- p.Asn124Ser Single submitter ⚠
- p.Asn145Lys Single submitter ⚠
- p.Cys119Arg Single submitter ⚠
- p.Cys92Ser Single submitter ⚠
- p.Gln81Glu Single submitter ⚠
- p.Glu249Gly Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Gly122Arg Single submitter ⚠
- p.Gly165Ser Single submitter ⚠
- p.Gly165Val Single submitter ⚠
- p.Gly183Ala Single submitter ⚠
- p.Gly183Val Single submitter ⚠
- p.Gly194Val Single submitter ⚠
- p.Gly246Val Single submitter ⚠
- p.Gly268Glu Single submitter ⚠
- p.Gly275Asp Single submitter ⚠
- p.Gly27Arg Single submitter ⚠
- p.His227Arg Single submitter ⚠
- p.His239= Single submitter
- p.His62Tyr Single submitter ⚠
- p.Ile217Met Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu242= Single submitter
- p.Leu280= Single submitter
- p.Leu34Pro Single submitter ⚠
- p.Leu85Met Single submitter ⚠
- p.Met77Thr Single submitter ⚠
- p.Phe13Leu Single submitter ⚠
- p.Pro15His Single submitter ⚠
- p.Ser129Arg Single submitter ⚠
- p.Ser154Arg Single submitter ⚠
- p.Ser188Arg Single submitter ⚠
- p.Ser256= Single submitter
- p.Ser25Asn Single submitter ⚠
- p.Thr196Ser Single submitter ⚠
- p.Tyr176Cys Single submitter ⚠
- p.Tyr265= Single submitter
- p.Tyr276Cys Single submitter ⚠
- p.Val104Met Single submitter ⚠
- p.Val127Leu Single submitter ⚠
- p.Val167Ala Single submitter ⚠
- p.Val180Glu Single submitter ⚠
- p.Val40Met Single submitter ⚠
- p.Val73Met Single submitter ⚠