DHRS7C — 49 ClinVar variants
All ClinVar germline DHRS7C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
2 Benign · 47 Uncertain significance
Full DHRS7C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHRS7C p.Ala135Asp Uncertain significance Single submitter
- DHRS7C p.Ala149Thr Uncertain significance Single submitter
- DHRS7C p.Ala281Val Uncertain significance Single submitter
- DHRS7C p.Ala5Thr Uncertain significance Single submitter
- DHRS7C p.Arg206Leu Uncertain significance Single submitter
- DHRS7C p.Arg225Gln Uncertain significance Single submitter
- DHRS7C p.Asn164Ser Uncertain significance Single submitter
- DHRS7C p.Asp143His Uncertain significance Single submitter
- DHRS7C p.Asp213Asn Uncertain significance Single submitter
- DHRS7C p.Asp44Asn Uncertain significance Single submitter
- DHRS7C p.Glu210Gln Uncertain significance Single submitter
- DHRS7C p.Glu232Asp Uncertain significance Single submitter
- DHRS7C p.Glu25Lys Uncertain significance Single submitter
- DHRS7C p.Gly181Glu Uncertain significance Single submitter
- DHRS7C p.Gly234Arg Uncertain significance Single submitter
- DHRS7C p.Gly300Arg Uncertain significance Single submitter
- DHRS7C p.Gly60Ser Uncertain significance Single submitter
- DHRS7C p.His253Leu Uncertain significance Single submitter
- DHRS7C p.Ile146Asn Uncertain significance Single submitter
- DHRS7C p.Ile216Thr Uncertain significance Single submitter
- DHRS7C p.Leu161Gln Uncertain significance Single submitter
- DHRS7C p.Leu205Phe Uncertain significance Single submitter
- DHRS7C p.Lys159Glu Uncertain significance Single submitter
- DHRS7C p.Phe201Cys Uncertain significance Single submitter
- DHRS7C p.Phe91Leu Uncertain significance Single submitter
- DHRS7C p.Pro231Leu Uncertain significance Single submitter
- DHRS7C p.Pro279His Uncertain significance Single submitter
- DHRS7C p.Pro87Thr Uncertain significance Single submitter
- DHRS7C p.Ser17Arg Uncertain significance Single submitter
- DHRS7C p.Thr264Ala Uncertain significance Single submitter
- DHRS7C p.Val176Ala Uncertain significance Single submitter
- DHRS7C p.Val229Ala Uncertain significance Single submitter
- DHRS7C p.Val84Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- DHRS7C p.Arg263Gly Uncertain significance Single submitter
- DHRS7C p.Glu291Gln Uncertain significance Single submitter
- DHRS7C p.Gly200Ser Uncertain significance Single submitter
- DHRS7C p.Gly61Glu Uncertain significance Single submitter
- DHRS7C p.His136Gln Uncertain significance Single submitter
- DHRS7C p.Met165Val Uncertain significance Single submitter
- DHRS7C p.Pro10Ser Uncertain significance Single submitter
- DHRS7C p.Pro154His Uncertain significance Single submitter
- DHRS7C p.Ser167Thr Uncertain significance Single submitter
- DHRS7C p.Ser88Arg Uncertain significance Single submitter
- DHRS7C p.Tyr284His Uncertain significance Single submitter
- DHRS7C p.Val106Ala Uncertain significance Single submitter
- DHRS7C p.Val252Met Uncertain significance Single submitter
- DHRS7C p.Val26Gly Uncertain significance Single submitter
All DHRS7C variants
Benign 2
- c.155-10T>C Single submitter
- c.268-12T>C Single submitter
Uncertain significance 47
- p.Ala135Asp Single submitter ⚠
- p.Ala149Thr Single submitter ⚠
- p.Ala281Val Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg206Leu Single submitter ⚠
- p.Arg225Gln Single submitter ⚠
- p.Arg263Gly Single submitter ⚠
- p.Asn164Ser Single submitter ⚠
- p.Asp143His Single submitter ⚠
- p.Asp213Asn Single submitter ⚠
- p.Asp44Asn Single submitter ⚠
- p.Glu210Gln Single submitter ⚠
- p.Glu232Asp Single submitter ⚠
- p.Glu25Lys Single submitter ⚠
- p.Glu291Gln Single submitter ⚠
- p.Gly181Glu Single submitter ⚠
- p.Gly200Ser Single submitter ⚠
- p.Gly234Arg Single submitter ⚠
- p.Gly300Arg Single submitter ⚠
- p.Gly60Ser Single submitter ⚠
- p.Gly61Glu Single submitter ⚠
- p.His136Gln Single submitter ⚠
- p.His253Leu Single submitter ⚠
- p.Ile146Asn Single submitter ⚠
- p.Ile216Thr Single submitter ⚠
- p.Leu161Gln Single submitter ⚠
- p.Leu205Phe Single submitter ⚠
- p.Lys159Glu Single submitter ⚠
- p.Met165Val Single submitter ⚠
- p.Phe201Cys Single submitter ⚠
- p.Phe91Leu Single submitter ⚠
- p.Pro10Ser Single submitter ⚠
- p.Pro154His Single submitter ⚠
- p.Pro231Leu Single submitter ⚠
- p.Pro279His Single submitter ⚠
- p.Pro87Thr Single submitter ⚠
- p.Ser167Thr Single submitter ⚠
- p.Ser17Arg Single submitter ⚠
- p.Ser88Arg Single submitter ⚠
- p.Thr264Ala Single submitter ⚠
- p.Tyr284His Single submitter ⚠
- p.Val106Ala Single submitter ⚠
- p.Val176Ala Single submitter ⚠
- p.Val229Ala Single submitter ⚠
- p.Val252Met Single submitter ⚠
- p.Val26Gly Single submitter ⚠
- p.Val84Met Single submitter ⚠