DHX15 — 39 ClinVar variants
All ClinVar germline DHX15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Likely benign · 37 Uncertain significance
Full DHX15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHX15 p.Arg243Cys Uncertain significance Single submitter
- DHX15 p.Arg399Cys Uncertain significance Single submitter
- DHX15 p.Arg49Lys Uncertain significance Single submitter
- DHX15 p.Asn120Ser Uncertain significance Single submitter
- DHX15 p.Asn410Ser Uncertain significance Single submitter
- DHX15 p.Asn659Ser Uncertain significance Single submitter
- DHX15 p.Gly16Ser Uncertain significance Single submitter
- DHX15 p.Gly47Ala Uncertain significance Single submitter
- DHX15 p.Ile620Arg Uncertain significance Single submitter
- DHX15 p.Ile784Val Uncertain significance Single submitter
-
DHX15 p.Lys443Glu
Uncertain significance
Single submitter
patent ductus arteriosus
- DHX15 p.Lys777Arg Uncertain significance Single submitter
- DHX15 p.Met68Val Uncertain significance Single submitter
- DHX15 p.Thr22Ile Uncertain significance Single submitter
- DHX15 p.Val211Met Uncertain significance Single submitter
- DHX15 p.Val575Ala Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- DHX15 p.Ala785Val Uncertain significance Single submitter
- DHX15 p.Ala83Gly Uncertain significance Single submitter
- DHX15 p.Arg19Gly Uncertain significance Single submitter
- DHX15 p.Arg42Gln Uncertain significance Single submitter
- DHX15 p.Arg44His Uncertain significance Single submitter
- DHX15 p.Arg782His Uncertain significance Single submitter
- DHX15 p.Asn497Asp Uncertain significance Single submitter
- DHX15 p.Asn659Asp Uncertain significance Single submitter
- DHX15 p.Gly16Cys Uncertain significance Single submitter
- DHX15 p.His102Tyr Uncertain significance Single submitter
- DHX15 p.His105Arg Uncertain significance Single submitter
- DHX15 p.His81Arg Uncertain significance Single submitter
- DHX15 p.His81Asp Uncertain significance Single submitter
- DHX15 p.His96Tyr Uncertain significance Single submitter
- DHX15 p.Lys17Gln Uncertain significance Single submitter
- DHX15 p.Lys367Gln Uncertain significance Single submitter
- DHX15 p.Pro184Ala Uncertain significance Single submitter
- DHX15 p.Thr101Met Uncertain significance Single submitter
- DHX15 p.Thr109Met Uncertain significance Single submitter
- DHX15 p.Thr681Ile Uncertain significance Single submitter
- DHX15 p.Thr92Met Uncertain significance Single submitter
All DHX15 variants
Uncertain significance 37
- p.Ala785Val Single submitter ⚠
- p.Ala83Gly Single submitter ⚠
- p.Arg19Gly Single submitter ⚠
- p.Arg243Cys Single submitter ⚠
- p.Arg399Cys Single submitter ⚠
- p.Arg42Gln Single submitter ⚠
- p.Arg44His Single submitter ⚠
- p.Arg49Lys Single submitter ⚠
- p.Arg782His Single submitter ⚠
- p.Asn120Ser Single submitter ⚠
- p.Asn410Ser Single submitter ⚠
- p.Asn497Asp Single submitter ⚠
- p.Asn659Asp Single submitter ⚠
- p.Asn659Ser Single submitter ⚠
- p.Gly16Cys Single submitter ⚠
- p.Gly16Ser Single submitter ⚠
- p.Gly47Ala Single submitter ⚠
- p.His102Tyr Single submitter ⚠
- p.His105Arg Single submitter ⚠
- p.His81Arg Single submitter ⚠
- p.His81Asp Single submitter ⚠
- p.His96Tyr Single submitter ⚠
- p.Ile620Arg Single submitter ⚠
- p.Ile784Val Single submitter ⚠
- p.Lys17Gln Single submitter ⚠
- p.Lys367Gln Single submitter ⚠
- p.Lys443Glu Single submitter patent ductus arteriosus ⚠
- p.Lys777Arg Single submitter ⚠
- p.Met68Val Single submitter ⚠
- p.Pro184Ala Single submitter ⚠
- p.Thr101Met Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Thr22Ile Single submitter ⚠
- p.Thr681Ile Single submitter ⚠
- p.Thr92Met Single submitter ⚠
- p.Val211Met Single submitter ⚠
- p.Val575Ala Single submitter ⚠