DHX29 — 167 ClinVar variants
All ClinVar germline DHX29 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 161 flagged for review →
6 Likely benign · 161 Uncertain significance
Full DHX29 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 161
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 101
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHX29 p.Thr47Ala Uncertain significance Multiple submitters
- DHX29 p.Ala10Pro Uncertain significance Single submitter
- DHX29 p.Ala1131Glu Uncertain significance Single submitter
- DHX29 p.Ala1187Thr Uncertain significance Single submitter
- DHX29 p.Ala1188Thr Uncertain significance Single submitter
- DHX29 p.Ala332Val Uncertain significance Single submitter
- DHX29 p.Ala33Pro Uncertain significance Single submitter
- DHX29 p.Ala348Ser Uncertain significance Single submitter
- DHX29 p.Ala349Val Uncertain significance Single submitter
- DHX29 p.Ala53Thr Uncertain significance Single submitter
- DHX29 p.Ala914Thr Uncertain significance Single submitter
- DHX29 p.Arg1012Cys Uncertain significance Single submitter
- DHX29 p.Arg1117Gln Uncertain significance Single submitter
- DHX29 p.Arg1309Cys Uncertain significance Single submitter
- DHX29 p.Arg24Thr Uncertain significance Single submitter
- DHX29 p.Arg388Thr Uncertain significance Single submitter
- DHX29 p.Arg578Gly Uncertain significance Single submitter
- DHX29 p.Arg578Pro Uncertain significance Single submitter
- DHX29 p.Arg589Gln Uncertain significance Single submitter
- DHX29 p.Arg631Gln Uncertain significance Single submitter
- DHX29 p.Arg632Ile Uncertain significance Single submitter
- DHX29 p.Arg978Cys Uncertain significance Single submitter
- DHX29 p.Arg992Gln Uncertain significance Single submitter
- DHX29 p.Asn110Ser Uncertain significance Single submitter
- DHX29 p.Asn224His Uncertain significance Single submitter
- DHX29 p.Asn228Thr Uncertain significance Single submitter
- DHX29 p.Asn497Ser Uncertain significance Single submitter
- DHX29 p.Asn512Thr Uncertain significance Single submitter
- DHX29 p.Asn526Asp Uncertain significance Single submitter
- DHX29 p.Asp1039Asn Uncertain significance Single submitter
- DHX29 p.Asp1119His Uncertain significance Single submitter
- DHX29 p.Asp702Gly Uncertain significance Single submitter
- DHX29 p.Cys648Ser Uncertain significance Single submitter
- DHX29 p.Gln1251His Uncertain significance Single submitter
- DHX29 p.Gln182His Uncertain significance Single submitter
- DHX29 p.Gln239Glu Uncertain significance Single submitter
- DHX29 p.Gln37Arg Uncertain significance Single submitter
- DHX29 p.Glu1180Lys Uncertain significance Single submitter
- DHX29 p.Glu1286Gln Uncertain significance Single submitter
- DHX29 p.Glu253Lys Uncertain significance Single submitter
- DHX29 p.Glu255Lys Uncertain significance Single submitter
- DHX29 p.Glu483Lys Uncertain significance Single submitter
- DHX29 p.Glu852Ala Uncertain significance Single submitter
- DHX29 p.Gly1028Arg Uncertain significance Single submitter
- DHX29 p.Gly1083Asp Uncertain significance Single submitter
- DHX29 p.Gly289Ala Uncertain significance Single submitter
- DHX29 p.His1257Gln Uncertain significance Single submitter
- DHX29 p.His729Tyr Uncertain significance Single submitter
- DHX29 p.His765Tyr Uncertain significance Single submitter
- DHX29 p.His957Tyr Uncertain significance Single submitter
- DHX29 p.Ile1010Met Uncertain significance Single submitter
- DHX29 p.Ile1022Val Uncertain significance Single submitter
- DHX29 p.Ile1115Val Uncertain significance Single submitter
- DHX29 p.Ile195Thr Uncertain significance Single submitter
- DHX29 p.Ile32Thr Uncertain significance Single submitter
- DHX29 p.Ile66Val Uncertain significance Single submitter
- DHX29 p.Ile731Val Uncertain significance Single submitter
- DHX29 p.Ile866Ser Uncertain significance Single submitter
- DHX29 p.Ile906Val Uncertain significance Single submitter
- DHX29 p.Ile939Val Uncertain significance Single submitter
- DHX29 p.Leu1066Pro Uncertain significance Single submitter
- DHX29 p.Leu1289Arg Uncertain significance Single submitter
- DHX29 p.Leu272Gln Uncertain significance Single submitter
- DHX29 p.Leu676Pro Uncertain significance Single submitter
- DHX29 p.Lys1242Glu Uncertain significance Single submitter
- DHX29 p.Lys1355Arg Uncertain significance Single submitter
- DHX29 p.Lys299Arg Uncertain significance Single submitter
- DHX29 p.Lys327Arg Uncertain significance Single submitter
- DHX29 p.Lys779Glu Uncertain significance Single submitter
- DHX29 p.Met229Thr Uncertain significance Single submitter
- DHX29 p.Met482Val Uncertain significance Single submitter
- DHX29 p.Phe713Leu Uncertain significance Single submitter
- DHX29 p.Phe873Ile Uncertain significance Single submitter
- DHX29 p.Phe969Ser Uncertain significance Single submitter
- DHX29 p.Pro184Ser Uncertain significance Single submitter
- DHX29 p.Pro193Ser Uncertain significance Single submitter
- DHX29 p.Pro214Leu Uncertain significance Single submitter
- DHX29 p.Pro361Ser Uncertain significance Single submitter
- DHX29 p.Pro606Leu Uncertain significance Single submitter
- DHX29 p.Pro842Thr Uncertain significance Single submitter
- DHX29 p.Ser1191Leu Uncertain significance Single submitter
- DHX29 p.Ser1338Ala Uncertain significance Single submitter
- DHX29 p.Ser1350Pro Uncertain significance Single submitter
- DHX29 p.Ser337Asn Uncertain significance Single submitter
- DHX29 p.Ser529Leu Uncertain significance Single submitter
- DHX29 p.Ser558Asn Uncertain significance Single submitter
- DHX29 p.Ser694Arg Uncertain significance Single submitter
- DHX29 p.Ser963Asn Uncertain significance Single submitter
- DHX29 p.Thr1137Lys Uncertain significance Single submitter
- DHX29 p.Thr1361Met Uncertain significance Single submitter
- DHX29 p.Thr427Ala Uncertain significance Single submitter
- DHX29 p.Thr484Ser Uncertain significance Single submitter
- DHX29 p.Thr948Ala Uncertain significance Single submitter
- DHX29 p.Tyr369Cys Uncertain significance Single submitter
- DHX29 p.Val101Met Uncertain significance Single submitter
- DHX29 p.Val1304Ile Uncertain significance Single submitter
- DHX29 p.Val1334Ile Uncertain significance Single submitter
- DHX29 p.Val1339Ile Uncertain significance Single submitter
- DHX29 p.Val814Ala Uncertain significance Single submitter
- DHX29 p.Val923Ile Uncertain significance Single submitter
- DHX29 p.Val943Glu Uncertain significance Single submitter
Predictors split 60
The independent predictors disagree with each other — read with care.
- DHX29 p.Ala1121Val Uncertain significance Single submitter
- DHX29 p.Ala1218Val Uncertain significance Single submitter
- DHX29 p.Ala158Thr Uncertain significance Single submitter
- DHX29 p.Arg1054Gly Uncertain significance Single submitter
- DHX29 p.Arg1162Trp Uncertain significance Single submitter
- DHX29 p.Arg1163Gly Uncertain significance Single submitter
- DHX29 p.Arg1263Gln Uncertain significance Single submitter
- DHX29 p.Arg447Cys Uncertain significance Single submitter
- DHX29 p.Arg578Gln Uncertain significance Single submitter
- DHX29 p.Arg97Ile Uncertain significance Single submitter
- DHX29 p.Asn1227Ser Uncertain significance Single submitter
- DHX29 p.Asp259Glu Uncertain significance Single submitter
- DHX29 p.Asp420Glu Uncertain significance Single submitter
- DHX29 p.Asp420Val Uncertain significance Single submitter
- DHX29 p.Cys1245Tyr Uncertain significance Single submitter
- DHX29 p.Cys623Arg Uncertain significance Single submitter
- DHX29 p.Cys670Tyr Uncertain significance Single submitter
- DHX29 p.Gln96His Uncertain significance Single submitter
- DHX29 p.Glu1345Ala Uncertain significance Single submitter
- DHX29 p.Glu1352Gln Uncertain significance Single submitter
- DHX29 p.Glu95Gly Uncertain significance Single submitter
- DHX29 p.Gly1116Cys Uncertain significance Single submitter
- DHX29 p.Gly651Arg Uncertain significance Single submitter
- DHX29 p.Gly653Ala Uncertain significance Single submitter
- DHX29 p.His310Arg Uncertain significance Single submitter
- DHX29 p.His438Asn Uncertain significance Single submitter
- DHX29 p.Ile1046Met Uncertain significance Single submitter
- DHX29 p.Ile1302Met Uncertain significance Single submitter
- DHX29 p.Ile1302Thr Uncertain significance Single submitter
- DHX29 p.Ile1356Phe Uncertain significance Single submitter
- DHX29 p.Ile700Val Uncertain significance Single submitter
- DHX29 p.Ile717Thr Uncertain significance Single submitter
- DHX29 p.Leu499Pro Uncertain significance Single submitter
- DHX29 p.Leu676Phe Uncertain significance Single submitter
- DHX29 p.Leu687Ile Uncertain significance Single submitter
- DHX29 p.Leu847Pro Uncertain significance Single submitter
- DHX29 p.Lys1036Ile Uncertain significance Single submitter
- DHX29 p.Lys1084Arg Uncertain significance Single submitter
- DHX29 p.Lys1147Thr Uncertain significance Single submitter
- DHX29 p.Lys1276Arg Uncertain significance Single submitter
- DHX29 p.Lys1342Glu Uncertain significance Single submitter
- DHX29 p.Lys358Arg Uncertain significance Single submitter
- DHX29 p.Pro45Leu Uncertain significance Single submitter
- DHX29 p.Pro460Ala Uncertain significance Single submitter
- DHX29 p.Ser1191Pro Uncertain significance Single submitter
- DHX29 p.Ser1193Phe Uncertain significance Single submitter
- DHX29 p.Ser1196Cys Uncertain significance Single submitter
- DHX29 p.Ser726Phe Uncertain significance Single submitter
- DHX29 p.Ser84Tyr Uncertain significance Single submitter
- DHX29 p.Ser895Cys Uncertain significance Single submitter
- DHX29 p.Thr1137Met Uncertain significance Single submitter
- DHX29 p.Thr559Arg Uncertain significance Single submitter
- DHX29 p.Thr584Ile Uncertain significance Single submitter
- DHX29 p.Thr968Met Uncertain significance Single submitter
- DHX29 p.Val1247Met Uncertain significance Single submitter
- DHX29 p.Val387Ile Uncertain significance Single submitter
- DHX29 p.Val421Asp Uncertain significance Single submitter
- DHX29 p.Val88Ala Uncertain significance Single submitter
- DHX29 p.Val942Ile Uncertain significance Single submitter
-
DHX29 p.Glu292Val
Uncertain significance
No assertion criteria
prostate cancer
All DHX29 variants
Likely benign 6
- p.Arg655Lys Single submitter
- p.Gly1144= Single submitter
- p.His1268Tyr Single submitter
- p.Ile85Val Single submitter
- p.Met225Thr Single submitter
- p.Tyr151His Single submitter
Uncertain significance 161
- p.Thr47Ala Multiple submitters ⚠
- p.Ala10Pro Single submitter ⚠
- p.Ala1121Val Single submitter ⚠
- p.Ala1131Glu Single submitter ⚠
- p.Ala1187Thr Single submitter ⚠
- p.Ala1188Thr Single submitter ⚠
- p.Ala1218Val Single submitter ⚠
- p.Ala158Thr Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala33Pro Single submitter ⚠
- p.Ala348Ser Single submitter ⚠
- p.Ala349Val Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Ala914Thr Single submitter ⚠
- p.Arg1012Cys Single submitter ⚠
- p.Arg1054Gly Single submitter ⚠
- p.Arg1117Gln Single submitter ⚠
- p.Arg1162Trp Single submitter ⚠
- p.Arg1163Gly Single submitter ⚠
- p.Arg1263Gln Single submitter ⚠
- p.Arg1309Cys Single submitter ⚠
- p.Arg24Thr Single submitter ⚠
- p.Arg388Thr Single submitter ⚠
- p.Arg447Cys Single submitter ⚠
- p.Arg578Gln Single submitter ⚠
- p.Arg578Gly Single submitter ⚠
- p.Arg578Pro Single submitter ⚠
- p.Arg589Gln Single submitter ⚠
- p.Arg631Gln Single submitter ⚠
- p.Arg632Ile Single submitter ⚠
- p.Arg978Cys Single submitter ⚠
- p.Arg97Ile Single submitter ⚠
- p.Arg992Gln Single submitter ⚠
- p.Asn110Ser Single submitter ⚠
- p.Asn1227Ser Single submitter ⚠
- p.Asn224His Single submitter ⚠
- p.Asn228Thr Single submitter ⚠
- p.Asn497Ser Single submitter ⚠
- p.Asn512Thr Single submitter ⚠
- p.Asn526Asp Single submitter ⚠
- p.Asp1039Asn Single submitter ⚠
- p.Asp1119His Single submitter ⚠
- p.Asp259Glu Single submitter ⚠
- p.Asp420Glu Single submitter ⚠
- p.Asp420Val Single submitter ⚠
- p.Asp702Gly Single submitter ⚠
- p.Cys1245Tyr Single submitter ⚠
- p.Cys623Arg Single submitter ⚠
- p.Cys648Ser Single submitter ⚠
- p.Cys670Tyr Single submitter ⚠
- p.Gln1251His Single submitter ⚠
- p.Gln182His Single submitter ⚠
- p.Gln239Glu Single submitter ⚠
- p.Gln37Arg Single submitter ⚠
- p.Gln96His Single submitter ⚠
- p.Glu1180Lys Single submitter ⚠
- p.Glu1286Gln Single submitter ⚠
- p.Glu1345Ala Single submitter ⚠
- p.Glu1352Gln Single submitter ⚠
- p.Glu253Lys Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu483Lys Single submitter ⚠
- p.Glu852Ala Single submitter ⚠
- p.Glu95Gly Single submitter ⚠
- p.Gly1028Arg Single submitter ⚠
- p.Gly1083Asp Single submitter ⚠
- p.Gly1116Cys Single submitter ⚠
- p.Gly289Ala Single submitter ⚠
- p.Gly651Arg Single submitter ⚠
- p.Gly653Ala Single submitter ⚠
- p.His1257Gln Single submitter ⚠
- p.His310Arg Single submitter ⚠
- p.His438Asn Single submitter ⚠
- p.His729Tyr Single submitter ⚠
- p.His765Tyr Single submitter ⚠
- p.His957Tyr Single submitter ⚠
- p.Ile1010Met Single submitter ⚠
- p.Ile1022Val Single submitter ⚠
- p.Ile1046Met Single submitter ⚠
- p.Ile1115Val Single submitter ⚠
- p.Ile1302Met Single submitter ⚠
- p.Ile1302Thr Single submitter ⚠
- p.Ile1356Phe Single submitter ⚠
- p.Ile195Thr Single submitter ⚠
- p.Ile32Thr Single submitter ⚠
- p.Ile66Val Single submitter ⚠
- p.Ile700Val Single submitter ⚠
- p.Ile717Thr Single submitter ⚠
- p.Ile731Val Single submitter ⚠
- p.Ile866Ser Single submitter ⚠
- p.Ile906Val Single submitter ⚠
- p.Ile939Val Single submitter ⚠
- p.Leu1066Pro Single submitter ⚠
- p.Leu1289Arg Single submitter ⚠
- p.Leu272Gln Single submitter ⚠
- p.Leu499Pro Single submitter ⚠
- p.Leu676Phe Single submitter ⚠
- p.Leu676Pro Single submitter ⚠
- p.Leu687Ile Single submitter ⚠
- p.Leu847Pro Single submitter ⚠
- p.Lys1036Ile Single submitter ⚠
- p.Lys1084Arg Single submitter ⚠
- p.Lys1147Thr Single submitter ⚠
- p.Lys1242Glu Single submitter ⚠
- p.Lys1276Arg Single submitter ⚠
- p.Lys1342Glu Single submitter ⚠
- p.Lys1355Arg Single submitter ⚠
- p.Lys299Arg Single submitter ⚠
- p.Lys327Arg Single submitter ⚠
- p.Lys358Arg Single submitter ⚠
- p.Lys779Glu Single submitter ⚠
- p.Met229Thr Single submitter ⚠
- p.Met482Val Single submitter ⚠
- p.Phe713Leu Single submitter ⚠
- p.Phe873Ile Single submitter ⚠
- p.Phe969Ser Single submitter ⚠
- p.Pro184Ser Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro214Leu Single submitter ⚠
- p.Pro361Ser Single submitter ⚠
- p.Pro45Leu Single submitter ⚠
- p.Pro460Ala Single submitter ⚠
- p.Pro606Leu Single submitter ⚠
- p.Pro842Thr Single submitter ⚠
- p.Ser1191Leu Single submitter ⚠
- p.Ser1191Pro Single submitter ⚠
- p.Ser1193Phe Single submitter ⚠
- p.Ser1196Cys Single submitter ⚠
- p.Ser1338Ala Single submitter ⚠
- p.Ser1350Pro Single submitter ⚠
- p.Ser337Asn Single submitter ⚠
- p.Ser529Leu Single submitter ⚠
- p.Ser558Asn Single submitter ⚠
- p.Ser694Arg Single submitter ⚠
- p.Ser726Phe Single submitter ⚠
- p.Ser84Tyr Single submitter ⚠
- p.Ser895Cys Single submitter ⚠
- p.Ser963Asn Single submitter ⚠
- p.Thr1137Lys Single submitter ⚠
- p.Thr1137Met Single submitter ⚠
- p.Thr1361Met Single submitter ⚠
- p.Thr427Ala Single submitter ⚠
- p.Thr484Ser Single submitter ⚠
- p.Thr559Arg Single submitter ⚠
- p.Thr584Ile Single submitter ⚠
- p.Thr948Ala Single submitter ⚠
- p.Thr968Met Single submitter ⚠
- p.Tyr369Cys Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val1247Met Single submitter ⚠
- p.Val1304Ile Single submitter ⚠
- p.Val1334Ile Single submitter ⚠
- p.Val1339Ile Single submitter ⚠
- p.Val387Ile Single submitter ⚠
- p.Val421Asp Single submitter ⚠
- p.Val814Ala Single submitter ⚠
- p.Val88Ala Single submitter ⚠
- p.Val923Ile Single submitter ⚠
- p.Val942Ile Single submitter ⚠
- p.Val943Glu Single submitter ⚠
- p.Glu292Val No assertion criteria prostate cancer ⚠