DHX33 — 112 ClinVar variants
All ClinVar germline DHX33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
4 Likely benign · 108 Uncertain significance
Full DHX33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHX33 p.Ala473Thr Uncertain significance Single submitter
- DHX33 p.Ala507Ser Uncertain significance Single submitter
- DHX33 p.Ala633Thr Uncertain significance Single submitter
- DHX33 p.Ala705Ser Uncertain significance Single submitter
- DHX33 p.Arg186Gln Uncertain significance Single submitter
- DHX33 p.Arg186Trp Uncertain significance Single submitter
- DHX33 p.Arg309Gln Uncertain significance Single submitter
- DHX33 p.Arg393Gln Uncertain significance Single submitter
- DHX33 p.Arg402His Uncertain significance Single submitter
- DHX33 p.Arg405Thr Uncertain significance Single submitter
- DHX33 p.Arg416Gln Uncertain significance Single submitter
- DHX33 p.Arg416Trp Uncertain significance Single submitter
- DHX33 p.Arg542Pro Uncertain significance Single submitter
- DHX33 p.Arg549His Uncertain significance Single submitter
- DHX33 p.Arg567Gln Uncertain significance Single submitter
- DHX33 p.Asn582Thr Uncertain significance Single submitter
- DHX33 p.Asn675Ser Uncertain significance Single submitter
- DHX33 p.Cys623Arg Uncertain significance Single submitter
- DHX33 p.Cys623Tyr Uncertain significance Single submitter
- DHX33 p.Gln109Glu Uncertain significance Single submitter
- DHX33 p.Gln487His Uncertain significance Single submitter
- DHX33 p.Gln57Glu Uncertain significance Single submitter
- DHX33 p.Glu195Gly Uncertain significance Single submitter
- DHX33 p.Glu252Gly Uncertain significance Single submitter
- DHX33 p.Glu433Asp Uncertain significance Single submitter
- DHX33 p.Glu543Ala Uncertain significance Single submitter
- DHX33 p.Glu618Asp Uncertain significance Single submitter
- DHX33 p.Gly42Ser Uncertain significance Single submitter
- DHX33 p.Gly573Arg Uncertain significance Single submitter
- DHX33 p.His483Arg Uncertain significance Single submitter
- DHX33 p.Ile291Val Uncertain significance Single submitter
- DHX33 p.Ile352Val Uncertain significance Single submitter
- DHX33 p.Ile356Val Uncertain significance Single submitter
- DHX33 p.Ile510Thr Uncertain significance Single submitter
- DHX33 p.Ile602Thr Uncertain significance Single submitter
- DHX33 p.Ile610Val Uncertain significance Single submitter
- DHX33 p.Leu488Val Uncertain significance Single submitter
- DHX33 p.Leu682Phe Uncertain significance Single submitter
- DHX33 p.Lys515Arg Uncertain significance Single submitter
- DHX33 p.Lys515Glu Uncertain significance Single submitter
- DHX33 p.Lys570Gln Uncertain significance Single submitter
- DHX33 p.Met230Lys Uncertain significance Single submitter
- DHX33 p.Met560Val Uncertain significance Single submitter
- DHX33 p.Met679Thr Uncertain significance Single submitter
- DHX33 p.Phe426Ser Uncertain significance Single submitter
- DHX33 p.Phe629Leu Uncertain significance Single submitter
- DHX33 p.Pro332Leu Uncertain significance Single submitter
- DHX33 p.Pro504His Uncertain significance Single submitter
- DHX33 p.Pro53Ser Uncertain significance Single submitter
- DHX33 p.Pro637Ser Uncertain significance Single submitter
- DHX33 p.Pro663Thr Uncertain significance Single submitter
- DHX33 p.Ser189Ile Uncertain significance Single submitter
- DHX33 p.Ser21Gly Uncertain significance Single submitter
- DHX33 p.Ser240Pro Uncertain significance Single submitter
- DHX33 p.Thr233Met Uncertain significance Single submitter
- DHX33 p.Thr307Met Uncertain significance Single submitter
- DHX33 p.Thr489Ala Uncertain significance Single submitter
- DHX33 p.Thr99Ile Uncertain significance Single submitter
- DHX33 p.Tyr242His Uncertain significance Single submitter
- DHX33 p.Val324Phe Uncertain significance Single submitter
- DHX33 p.Val534Ile Uncertain significance Single submitter
Predictors split 48
The independent predictors disagree with each other — read with care.
- DHX33 p.Ala343Ser Uncertain significance Single submitter
- DHX33 p.Ala399Gly Uncertain significance Single submitter
- DHX33 p.Ala448Thr Uncertain significance Single submitter
- DHX33 p.Ala470Val Uncertain significance Single submitter
- DHX33 p.Ala694Ser Uncertain significance Single submitter
- DHX33 p.Arg12Lys Uncertain significance Single submitter
- DHX33 p.Arg216Thr Uncertain significance Single submitter
- DHX33 p.Arg393Trp Uncertain significance Single submitter
- DHX33 p.Arg541Gln Uncertain significance Single submitter
- DHX33 p.Arg541Trp Uncertain significance Single submitter
- DHX33 p.Arg549Cys Uncertain significance Single submitter
- DHX33 p.Arg567Trp Uncertain significance Single submitter
- DHX33 p.Arg622His Uncertain significance Single submitter
- DHX33 p.Arg72Leu Uncertain significance Single submitter
- DHX33 p.Arg80Gln Uncertain significance Single submitter
- DHX33 p.Arg80Leu Uncertain significance Single submitter
- DHX33 p.Asp427Val Uncertain significance Single submitter
- DHX33 p.Glu521Asp Uncertain significance Single submitter
- DHX33 p.Glu594Gly Uncertain significance Single submitter
- DHX33 p.Gly39Asp Uncertain significance Single submitter
- DHX33 p.Gly42Val Uncertain significance Single submitter
- DHX33 p.Gly44Ala Uncertain significance Single submitter
- DHX33 p.Gly573Asp Uncertain significance Single submitter
- DHX33 p.His660Leu Uncertain significance Single submitter
- DHX33 p.Ile525Val Uncertain significance Single submitter
- DHX33 p.Leu604Phe Uncertain significance Single submitter
- DHX33 p.Lys222Arg Uncertain significance Single submitter
- DHX33 p.Lys580Ile Uncertain significance Single submitter
- DHX33 p.Met630Val Uncertain significance Single submitter
- DHX33 p.Phe552Tyr Uncertain significance Single submitter
- DHX33 p.Pro257Leu Uncertain significance Single submitter
- DHX33 p.Pro382Thr Uncertain significance Single submitter
- DHX33 p.Ser411Gly Uncertain significance Single submitter
- DHX33 p.Ser612Pro Uncertain significance Single submitter
- DHX33 p.Ser61Asn Uncertain significance Single submitter
- DHX33 p.Thr307Arg Uncertain significance Single submitter
- DHX33 p.Thr590Met Likely benign Single submitter
- DHX33 p.Tyr250Cys Uncertain significance Single submitter
- DHX33 p.Tyr333Cys Uncertain significance Single submitter
- DHX33 p.Val151Ile Uncertain significance Single submitter
- DHX33 p.Val248Leu Uncertain significance Single submitter
- DHX33 p.Val278Ile Uncertain significance Single submitter
- DHX33 p.Val293Leu Uncertain significance Single submitter
- DHX33 p.Val391Met Uncertain significance Single submitter
- DHX33 p.Val431Met Uncertain significance Single submitter
- DHX33 p.Val454Met Uncertain significance Single submitter
- DHX33 p.Val531Leu Uncertain significance Single submitter
- DHX33 p.Val666Ile Uncertain significance Single submitter
All DHX33 variants
Likely benign 4
- p.Arg43Gly Single submitter
- p.Met322Leu Single submitter
- p.Thr590Met Single submitter ⚠
- p.Val617Met Single submitter
Uncertain significance 108
- p.Ala343Ser Single submitter ⚠
- p.Ala399Gly Single submitter ⚠
- p.Ala448Thr Single submitter ⚠
- p.Ala470Val Single submitter ⚠
- p.Ala473Thr Single submitter ⚠
- p.Ala507Ser Single submitter ⚠
- p.Ala633Thr Single submitter ⚠
- p.Ala694Ser Single submitter ⚠
- p.Ala705Ser Single submitter ⚠
- p.Arg12Lys Single submitter ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg216Thr Single submitter ⚠
- p.Arg309Gln Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg393Trp Single submitter ⚠
- p.Arg402His Single submitter ⚠
- p.Arg405Thr Single submitter ⚠
- p.Arg416Gln Single submitter ⚠
- p.Arg416Trp Single submitter ⚠
- p.Arg541Gln Single submitter ⚠
- p.Arg541Trp Single submitter ⚠
- p.Arg542Pro Single submitter ⚠
- p.Arg549Cys Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Arg567Gln Single submitter ⚠
- p.Arg567Trp Single submitter ⚠
- p.Arg622His Single submitter ⚠
- p.Arg72Leu Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Arg80Leu Single submitter ⚠
- p.Asn582Thr Single submitter ⚠
- p.Asn675Ser Single submitter ⚠
- p.Asp427Val Single submitter ⚠
- p.Cys623Arg Single submitter ⚠
- p.Cys623Tyr Single submitter ⚠
- p.Gln109Glu Single submitter ⚠
- p.Gln487His Single submitter ⚠
- p.Gln57Glu Single submitter ⚠
- p.Glu195Gly Single submitter ⚠
- p.Glu252Gly Single submitter ⚠
- p.Glu433Asp Single submitter ⚠
- p.Glu521Asp Single submitter ⚠
- p.Glu543Ala Single submitter ⚠
- p.Glu594Gly Single submitter ⚠
- p.Glu618Asp Single submitter ⚠
- p.Gly39Asp Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.Gly42Val Single submitter ⚠
- p.Gly44Ala Single submitter ⚠
- p.Gly573Arg Single submitter ⚠
- p.Gly573Asp Single submitter ⚠
- p.His483Arg Single submitter ⚠
- p.His660Leu Single submitter ⚠
- p.Ile291Val Single submitter ⚠
- p.Ile352Val Single submitter ⚠
- p.Ile356Val Single submitter ⚠
- p.Ile510Thr Single submitter ⚠
- p.Ile525Val Single submitter ⚠
- p.Ile602Thr Single submitter ⚠
- p.Ile610Val Single submitter ⚠
- p.Leu488Val Single submitter ⚠
- p.Leu604Phe Single submitter ⚠
- p.Leu682Phe Single submitter ⚠
- p.Lys222Arg Single submitter ⚠
- p.Lys515Arg Single submitter ⚠
- p.Lys515Glu Single submitter ⚠
- p.Lys570Gln Single submitter ⚠
- p.Lys580Ile Single submitter ⚠
- p.Met230Lys Single submitter ⚠
- p.Met560Val Single submitter ⚠
- p.Met630Val Single submitter ⚠
- p.Met679Thr Single submitter ⚠
- p.Phe426Ser Single submitter ⚠
- p.Phe552Tyr Single submitter ⚠
- p.Phe629Leu Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro332Leu Single submitter ⚠
- p.Pro382Thr Single submitter ⚠
- p.Pro504His Single submitter ⚠
- p.Pro53Ser Single submitter ⚠
- p.Pro637Ser Single submitter ⚠
- p.Pro663Thr Single submitter ⚠
- p.Ser189Ile Single submitter ⚠
- p.Ser21Gly Single submitter ⚠
- p.Ser240Pro Single submitter ⚠
- p.Ser411Gly Single submitter ⚠
- p.Ser612Pro Single submitter ⚠
- p.Ser61Asn Single submitter ⚠
- p.Thr233Met Single submitter ⚠
- p.Thr307Arg Single submitter ⚠
- p.Thr307Met Single submitter ⚠
- p.Thr489Ala Single submitter ⚠
- p.Thr99Ile Single submitter ⚠
- p.Tyr242His Single submitter ⚠
- p.Tyr250Cys Single submitter ⚠
- p.Tyr333Cys Single submitter ⚠
- p.Val151Ile Single submitter ⚠
- p.Val248Leu Single submitter ⚠
- p.Val278Ile Single submitter ⚠
- p.Val293Leu Single submitter ⚠
- p.Val324Phe Single submitter ⚠
- p.Val391Met Single submitter ⚠
- p.Val431Met Single submitter ⚠
- p.Val454Met Single submitter ⚠
- p.Val531Leu Single submitter ⚠
- p.Val534Ile Single submitter ⚠
- p.Val666Ile Single submitter ⚠