DHX35 — 88 ClinVar variants
All ClinVar germline DHX35 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →
1 Likely benign · 87 Uncertain significance
Full DHX35 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 87
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHX35 p.Ala579Val Uncertain significance Single submitter
- DHX35 p.Arg109Gln Uncertain significance Single submitter
- DHX35 p.Arg109Gly Uncertain significance Single submitter
- DHX35 p.Arg110Gly Uncertain significance Single submitter
- DHX35 p.Arg137Cys Uncertain significance Single submitter
- DHX35 p.Arg137His Uncertain significance Single submitter
- DHX35 p.Arg199Gln Uncertain significance Single submitter
- DHX35 p.Arg393Cys Uncertain significance Single submitter
- DHX35 p.Arg393His Uncertain significance Single submitter
- DHX35 p.Arg396Cys Uncertain significance Single submitter
- DHX35 p.Arg404Cys Uncertain significance Single submitter
- DHX35 p.Arg404Leu Uncertain significance Single submitter
- DHX35 p.Asn32Lys Uncertain significance Single submitter
- DHX35 p.Asn526Asp Uncertain significance Single submitter
- DHX35 p.Asp668Val Uncertain significance Single submitter
- DHX35 p.Gln251Glu Uncertain significance Single submitter
- DHX35 p.Glu131Lys Uncertain significance Single submitter
- DHX35 p.Glu25Asp Uncertain significance Single submitter
- DHX35 p.Glu48Gln Uncertain significance Single submitter
- DHX35 p.Glu507Lys Uncertain significance Single submitter
- DHX35 p.Glu657Gln Uncertain significance Single submitter
- DHX35 p.Glu657Lys Uncertain significance Single submitter
- DHX35 p.Glu679Gly Uncertain significance Single submitter
- DHX35 p.Gly200Glu Uncertain significance Single submitter
- DHX35 p.Gly392Arg Uncertain significance Single submitter
- DHX35 p.Gly574Arg Uncertain significance Single submitter
- DHX35 p.His62Arg Uncertain significance Single submitter
- DHX35 p.Ile374Val Uncertain significance Single submitter
- DHX35 p.Ile551Arg Uncertain significance Single submitter
- DHX35 p.Leu236His Uncertain significance Single submitter
- DHX35 p.Lys194Thr Uncertain significance Single submitter
- DHX35 p.Lys494Arg Uncertain significance Single submitter
- DHX35 p.Met306Ile Uncertain significance Single submitter
- DHX35 p.Phe219Leu Uncertain significance Single submitter
- DHX35 p.Phe280Leu Uncertain significance Single submitter
- DHX35 p.Pro451Leu Uncertain significance Single submitter
- DHX35 p.Pro55Gln Uncertain significance Single submitter
- DHX35 p.Pro55Leu Uncertain significance Single submitter
- DHX35 p.Pro603Leu Uncertain significance Single submitter
- DHX35 p.Ser46Pro Uncertain significance Single submitter
- DHX35 p.Thr106Asn Uncertain significance Single submitter
- DHX35 p.Thr115Ala Uncertain significance Single submitter
- DHX35 p.Thr147Met Uncertain significance Single submitter
- DHX35 p.Thr36Ala Uncertain significance Single submitter
- DHX35 p.Tyr368His Uncertain significance Single submitter
- DHX35 p.Val103Ile Uncertain significance Single submitter
- DHX35 p.Val127Leu Uncertain significance Single submitter
- DHX35 p.Val206Ile Uncertain significance Single submitter
- DHX35 p.Val20Ile Uncertain significance Single submitter
- DHX35 p.Val287Leu Uncertain significance Single submitter
Predictors split 37
The independent predictors disagree with each other — read with care.
- DHX35 p.Ala188Thr Uncertain significance Single submitter
- DHX35 p.Ala465Gly Uncertain significance Single submitter
- DHX35 p.Ala671Val Uncertain significance Single submitter
- DHX35 p.Arg101Ser Uncertain significance Single submitter
- DHX35 p.Arg217Trp Uncertain significance Single submitter
- DHX35 p.Arg366Gln Uncertain significance Single submitter
- DHX35 p.Arg371Gly Uncertain significance Single submitter
- DHX35 p.Arg398His Uncertain significance Single submitter
- DHX35 p.Arg474Cys Uncertain significance Single submitter
- DHX35 p.Asn559Asp Uncertain significance Single submitter
- DHX35 p.Asn559Ser Uncertain significance Single submitter
- DHX35 p.Asn617Ser Uncertain significance Single submitter
- DHX35 p.Asp227Gly Uncertain significance Single submitter
- DHX35 p.Asp231Glu Uncertain significance Single submitter
- DHX35 p.Cys233Arg Uncertain significance Single submitter
- DHX35 p.Gln50Arg Uncertain significance Single submitter
- DHX35 p.Gln593Pro Uncertain significance Single submitter
- DHX35 p.Gln71Glu Uncertain significance Single submitter
- DHX35 p.Glu263Lys Uncertain significance Single submitter
- DHX35 p.Gly14Asp Uncertain significance Single submitter
- DHX35 p.Gly503Ser Uncertain significance Single submitter
- DHX35 p.Gly688Arg Uncertain significance Single submitter
- DHX35 p.Ile551Met Uncertain significance Single submitter
- DHX35 p.Leu128Gln Uncertain significance Single submitter
- DHX35 p.Met448Thr Uncertain significance Single submitter
- DHX35 p.Met456Ile Uncertain significance Single submitter
- DHX35 p.Met495Val Uncertain significance Single submitter
- DHX35 p.Phe521Leu Uncertain significance Single submitter
- DHX35 p.Pro478Ala Uncertain significance Single submitter
- DHX35 p.Pro478Leu Uncertain significance Single submitter
- DHX35 p.Pro524Ser Uncertain significance Single submitter
- DHX35 p.Ser399Leu Uncertain significance Single submitter
- DHX35 p.Ser674Leu Uncertain significance Single submitter
- DHX35 p.Val120Ile Uncertain significance Single submitter
- DHX35 p.Val238Met Uncertain significance Single submitter
- DHX35 p.Val335Ile Uncertain significance Single submitter
- DHX35 p.Val522Ala Uncertain significance Single submitter
All DHX35 variants
Likely benign 1
- p.Ile67Val Single submitter
Uncertain significance 87
- p.Ala188Thr Single submitter ⚠
- p.Ala465Gly Single submitter ⚠
- p.Ala579Val Single submitter ⚠
- p.Ala671Val Single submitter ⚠
- p.Arg101Ser Single submitter ⚠
- p.Arg109Gln Single submitter ⚠
- p.Arg109Gly Single submitter ⚠
- p.Arg110Gly Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg199Gln Single submitter ⚠
- p.Arg217Trp Single submitter ⚠
- p.Arg366Gln Single submitter ⚠
- p.Arg371Gly Single submitter ⚠
- p.Arg393Cys Single submitter ⚠
- p.Arg393His Single submitter ⚠
- p.Arg396Cys Single submitter ⚠
- p.Arg398His Single submitter ⚠
- p.Arg404Cys Single submitter ⚠
- p.Arg404Leu Single submitter ⚠
- p.Arg474Cys Single submitter ⚠
- p.Asn32Lys Single submitter ⚠
- p.Asn526Asp Single submitter ⚠
- p.Asn559Asp Single submitter ⚠
- p.Asn559Ser Single submitter ⚠
- p.Asn617Ser Single submitter ⚠
- p.Asp227Gly Single submitter ⚠
- p.Asp231Glu Single submitter ⚠
- p.Asp668Val Single submitter ⚠
- p.Cys233Arg Single submitter ⚠
- p.Gln251Glu Single submitter ⚠
- p.Gln50Arg Single submitter ⚠
- p.Gln593Pro Single submitter ⚠
- p.Gln71Glu Single submitter ⚠
- p.Glu131Lys Single submitter ⚠
- p.Glu25Asp Single submitter ⚠
- p.Glu263Lys Single submitter ⚠
- p.Glu48Gln Single submitter ⚠
- p.Glu507Lys Single submitter ⚠
- p.Glu657Gln Single submitter ⚠
- p.Glu657Lys Single submitter ⚠
- p.Glu679Gly Single submitter ⚠
- p.Gly14Asp Single submitter ⚠
- p.Gly200Glu Single submitter ⚠
- p.Gly392Arg Single submitter ⚠
- p.Gly503Ser Single submitter ⚠
- p.Gly574Arg Single submitter ⚠
- p.Gly688Arg Single submitter ⚠
- p.His62Arg Single submitter ⚠
- p.Ile374Val Single submitter ⚠
- p.Ile551Arg Single submitter ⚠
- p.Ile551Met Single submitter ⚠
- p.Leu128Gln Single submitter ⚠
- p.Leu236His Single submitter ⚠
- p.Lys194Thr Single submitter ⚠
- p.Lys494Arg Single submitter ⚠
- p.Met306Ile Single submitter ⚠
- p.Met448Thr Single submitter ⚠
- p.Met456Ile Single submitter ⚠
- p.Met495Val Single submitter ⚠
- p.Phe219Leu Single submitter ⚠
- p.Phe280Leu Single submitter ⚠
- p.Phe521Leu Single submitter ⚠
- p.Pro451Leu Single submitter ⚠
- p.Pro478Ala Single submitter ⚠
- p.Pro478Leu Single submitter ⚠
- p.Pro524Ser Single submitter ⚠
- p.Pro55Gln Single submitter ⚠
- p.Pro55Leu Single submitter ⚠
- p.Pro603Leu Single submitter ⚠
- p.Ser399Leu Single submitter ⚠
- p.Ser46Pro Single submitter ⚠
- p.Ser674Leu Single submitter ⚠
- p.Thr106Asn Single submitter ⚠
- p.Thr115Ala Single submitter ⚠
- p.Thr147Met Single submitter ⚠
- p.Thr36Ala Single submitter ⚠
- p.Tyr368His Single submitter ⚠
- p.Val103Ile Single submitter ⚠
- p.Val120Ile Single submitter ⚠
- p.Val127Leu Single submitter ⚠
- p.Val206Ile Single submitter ⚠
- p.Val20Ile Single submitter ⚠
- p.Val238Met Single submitter ⚠
- p.Val287Leu Single submitter ⚠
- p.Val335Ile Single submitter ⚠
- p.Val522Ala Single submitter ⚠