DHX36 — 91 ClinVar variants
All ClinVar germline DHX36 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
4 Likely benign · 87 Uncertain significance
Full DHX36 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DHX36 p.Ala104Thr Uncertain significance Single submitter
- DHX36 p.Ala104Val Uncertain significance Single submitter
- DHX36 p.Ala456Val Uncertain significance Single submitter
- DHX36 p.Ala743Ser Uncertain significance Single submitter
- DHX36 p.Arg1001Gln Uncertain significance Single submitter
- DHX36 p.Arg196Gln Uncertain significance Single submitter
- DHX36 p.Arg429Gly Uncertain significance Single submitter
- DHX36 p.Arg452Gly Uncertain significance Single submitter
- DHX36 p.Arg480Gln Uncertain significance Single submitter
- DHX36 p.Arg996Gly Uncertain significance Single submitter
- DHX36 p.Asn222Ser Uncertain significance Single submitter
- DHX36 p.Asn884Ser Uncertain significance Single submitter
- DHX36 p.Asp445Gly Uncertain significance Single submitter
- DHX36 p.Asp826Ala Uncertain significance Single submitter
- DHX36 p.Cys381Arg Uncertain significance Single submitter
- DHX36 p.Cys909Ser Uncertain significance Single submitter
- DHX36 p.Gln598Glu Uncertain significance Single submitter
- DHX36 p.Gln7Lys Uncertain significance Single submitter
- DHX36 p.Glu76Ala Uncertain significance Single submitter
- DHX36 p.Glu93Lys Uncertain significance Single submitter
- DHX36 p.Gly25Arg Uncertain significance Single submitter
- DHX36 p.Gly55Arg Uncertain significance Single submitter
- DHX36 p.His505Arg Uncertain significance Single submitter
- DHX36 p.His882Asn Uncertain significance Single submitter
- DHX36 p.His944Tyr Uncertain significance Single submitter
- DHX36 p.Ile114Met Uncertain significance Single submitter
- DHX36 p.Ile157Met Uncertain significance Single submitter
- DHX36 p.Ile331Val Uncertain significance Single submitter
- DHX36 p.Ile363Val Uncertain significance Single submitter
- DHX36 p.Ile491Val Uncertain significance Single submitter
- DHX36 p.Ile572Val Uncertain significance Single submitter
- DHX36 p.Ile671Val Uncertain significance Single submitter
- DHX36 p.Ile835Val Uncertain significance Single submitter
- DHX36 p.Ile917Phe Uncertain significance Single submitter
- DHX36 p.Ile961Thr Uncertain significance Single submitter
- DHX36 p.Leu839Val Uncertain significance Single submitter
- DHX36 p.Lys404Arg Uncertain significance Single submitter
- DHX36 p.Met383Val Uncertain significance Single submitter
- DHX36 p.Met659Thr Uncertain significance Single submitter
- DHX36 p.Phe519Cys Uncertain significance Single submitter
- DHX36 p.Pro119Ser Uncertain significance Single submitter
- DHX36 p.Pro496Leu Uncertain significance Single submitter
- DHX36 p.Ser17Asn Uncertain significance Single submitter
- DHX36 p.Thr130Asn Uncertain significance Single submitter
- DHX36 p.Thr133Ala Uncertain significance Single submitter
- DHX36 p.Thr534Ile Uncertain significance Single submitter
- DHX36 p.Thr790Ala Uncertain significance Single submitter
- DHX36 p.Tyr5His Uncertain significance Single submitter
- DHX36 p.Tyr860Ser Uncertain significance Single submitter
- DHX36 p.Tyr898His Uncertain significance Single submitter
- DHX36 p.Val272Leu Uncertain significance Single submitter
- DHX36 p.Val427Ala Uncertain significance Single submitter
- DHX36 p.Val760Met Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- DHX36 p.Ala437Thr Uncertain significance Single submitter
- DHX36 p.Ala437Val Uncertain significance Single submitter
- DHX36 p.Ala490Gly Uncertain significance Single submitter
- DHX36 p.Arg16His Uncertain significance Single submitter
- DHX36 p.Arg772Cys Uncertain significance Single submitter
- DHX36 p.Arg772His Uncertain significance Single submitter
- DHX36 p.Asn796Lys Uncertain significance Single submitter
- DHX36 p.Asn970Asp Uncertain significance Single submitter
- DHX36 p.Asp742Asn Uncertain significance Single submitter
- DHX36 p.Cys234Ser Uncertain significance Single submitter
- DHX36 p.Gln224Arg Uncertain significance Single submitter
- DHX36 p.Gln535Leu Uncertain significance Single submitter
- DHX36 p.Glu449Gly Uncertain significance Single submitter
- DHX36 p.Glu466Val Uncertain significance Single submitter
- DHX36 p.Glu684Gln Uncertain significance Single submitter
- DHX36 p.Glu777Lys Uncertain significance Single submitter
- DHX36 p.Gly46Val Uncertain significance Single submitter
- DHX36 p.Gly71Arg Uncertain significance Single submitter
- DHX36 p.Gly773Arg Uncertain significance Single submitter
- DHX36 p.Ile363Met Uncertain significance Single submitter
- DHX36 p.Leu495Val Uncertain significance Single submitter
- DHX36 p.Leu520Phe Uncertain significance Single submitter
- DHX36 p.Met465Val Uncertain significance Single submitter
- DHX36 p.Pro542Ser Uncertain significance Single submitter
- DHX36 p.Pro608Ala Uncertain significance Single submitter
- DHX36 p.Pro608Ser Uncertain significance Single submitter
- DHX36 p.Ser584Gly Uncertain significance Single submitter
- DHX36 p.Thr530Ala Uncertain significance Single submitter
- DHX36 p.Tyr1007Cys Uncertain significance Single submitter
- DHX36 p.Tyr626Cys Uncertain significance Single submitter
- DHX36 p.Val272Ile Uncertain significance Single submitter
- DHX36 p.Val459Ala Uncertain significance Single submitter
- DHX36 p.Val483Ile Uncertain significance Single submitter
All DHX36 variants
Likely benign 4
- p.Gly25= Single submitter
- p.Met64Leu Single submitter
- p.Thr130Ala Single submitter
- p.Tyr324Cys Single submitter
Uncertain significance 87
- p.Ala104Thr Single submitter ⚠
- p.Ala104Val Single submitter ⚠
- p.Ala437Thr Single submitter ⚠
- p.Ala437Val Single submitter ⚠
- p.Ala456Val Single submitter ⚠
- p.Ala490Gly Single submitter ⚠
- p.Ala743Ser Single submitter ⚠
- p.Arg1001Gln Single submitter ⚠
- p.Arg16His Single submitter ⚠
- p.Arg196Gln Single submitter ⚠
- p.Arg429Gly Single submitter ⚠
- p.Arg452Gly Single submitter ⚠
- p.Arg480Gln Single submitter ⚠
- p.Arg772Cys Single submitter ⚠
- p.Arg772His Single submitter ⚠
- p.Arg996Gly Single submitter ⚠
- p.Asn222Ser Single submitter ⚠
- p.Asn796Lys Single submitter ⚠
- p.Asn884Ser Single submitter ⚠
- p.Asn970Asp Single submitter ⚠
- p.Asp445Gly Single submitter ⚠
- p.Asp742Asn Single submitter ⚠
- p.Asp826Ala Single submitter ⚠
- p.Cys234Ser Single submitter ⚠
- p.Cys381Arg Single submitter ⚠
- p.Cys909Ser Single submitter ⚠
- p.Gln224Arg Single submitter ⚠
- p.Gln535Leu Single submitter ⚠
- p.Gln598Glu Single submitter ⚠
- p.Gln7Lys Single submitter ⚠
- p.Glu449Gly Single submitter ⚠
- p.Glu466Val Single submitter ⚠
- p.Glu684Gln Single submitter ⚠
- p.Glu76Ala Single submitter ⚠
- p.Glu777Lys Single submitter ⚠
- p.Glu93Lys Single submitter ⚠
- p.Gly25Arg Single submitter ⚠
- p.Gly46Val Single submitter ⚠
- p.Gly55Arg Single submitter ⚠
- p.Gly71Arg Single submitter ⚠
- p.Gly773Arg Single submitter ⚠
- p.His505Arg Single submitter ⚠
- p.His882Asn Single submitter ⚠
- p.His944Tyr Single submitter ⚠
- p.Ile114Met Single submitter ⚠
- p.Ile157Met Single submitter ⚠
- p.Ile267del Single submitter DHX36-associated disorder
- p.Ile331Val Single submitter ⚠
- p.Ile363Met Single submitter ⚠
- p.Ile363Val Single submitter ⚠
- p.Ile491Val Single submitter ⚠
- p.Ile572Val Single submitter ⚠
- p.Ile671Val Single submitter ⚠
- p.Ile835Val Single submitter ⚠
- p.Ile917Phe Single submitter ⚠
- p.Ile961Thr Single submitter ⚠
- p.Leu495Val Single submitter ⚠
- p.Leu520Phe Single submitter ⚠
- p.Leu839Val Single submitter ⚠
- p.Lys404Arg Single submitter ⚠
- p.Met383Val Single submitter ⚠
- p.Met465Val Single submitter ⚠
- p.Met659Thr Single submitter ⚠
- p.Phe519Cys Single submitter ⚠
- p.Pro119Ser Single submitter ⚠
- p.Pro496Leu Single submitter ⚠
- p.Pro542Ser Single submitter ⚠
- p.Pro608Ala Single submitter ⚠
- p.Pro608Ser Single submitter ⚠
- p.Ser17Asn Single submitter ⚠
- p.Ser584Gly Single submitter ⚠
- p.Thr130Asn Single submitter ⚠
- p.Thr133Ala Single submitter ⚠
- p.Thr530Ala Single submitter ⚠
- p.Thr534Ile Single submitter ⚠
- p.Thr790Ala Single submitter ⚠
- p.Tyr1007Cys Single submitter ⚠
- p.Tyr5His Single submitter ⚠
- p.Tyr626Cys Single submitter ⚠
- p.Tyr860Ser Single submitter ⚠
- p.Tyr898His Single submitter ⚠
- p.Val272Ile Single submitter ⚠
- p.Val272Leu Single submitter ⚠
- p.Val427Ala Single submitter ⚠
- p.Val459Ala Single submitter ⚠
- p.Val483Ile Single submitter ⚠
- p.Val760Met Single submitter ⚠