DIPK1B — 114 ClinVar variants
All ClinVar germline DIPK1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 111 flagged for review →
4 Likely benign · 110 Uncertain significance
Full DIPK1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 111
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DIPK1B p.Ala132Thr Uncertain significance Single submitter
- DIPK1B p.Ala218Thr Uncertain significance Single submitter
- DIPK1B p.Ala218Val Uncertain significance Single submitter
- DIPK1B p.Ala259Thr Uncertain significance Single submitter
- DIPK1B p.Ala371Thr Uncertain significance Single submitter
- DIPK1B p.Arg128Gln Uncertain significance Single submitter
- DIPK1B p.Arg134Gln Uncertain significance Single submitter
- DIPK1B p.Arg145Gln Uncertain significance Single submitter
- DIPK1B p.Arg153Gln Uncertain significance Single submitter
- DIPK1B p.Arg188Gln Uncertain significance Single submitter
- DIPK1B p.Arg203His Uncertain significance Single submitter
- DIPK1B p.Arg249His Uncertain significance Single submitter
- DIPK1B p.Arg30Cys Uncertain significance Single submitter
- DIPK1B p.Arg30His Uncertain significance Single submitter
- DIPK1B p.Arg333Gly Uncertain significance Single submitter
- DIPK1B p.Arg344His Uncertain significance Single submitter
- DIPK1B p.Arg374Gln Uncertain significance Single submitter
- DIPK1B p.Arg374Trp Uncertain significance Single submitter
- DIPK1B p.Arg56His Uncertain significance Single submitter
- DIPK1B p.Arg92Lys Uncertain significance Single submitter
- DIPK1B p.Asn204Asp Uncertain significance Single submitter
- DIPK1B p.Asp124Asn Uncertain significance Single submitter
- DIPK1B p.Cys357Ser Uncertain significance Single submitter
- DIPK1B p.Gln21Pro Uncertain significance Single submitter
- DIPK1B p.Gln363His Uncertain significance Single submitter
- DIPK1B p.Gln405His Uncertain significance Single submitter
- DIPK1B p.Glu120Gly Uncertain significance Single submitter
- DIPK1B p.Glu214Gly Uncertain significance Single submitter
- DIPK1B p.Glu283Gln Uncertain significance Single submitter
- DIPK1B p.Glu335Lys Uncertain significance Single submitter
- DIPK1B p.Glu407Gly Uncertain significance Single submitter
- DIPK1B p.Glu55Lys Uncertain significance Single submitter
- DIPK1B p.Gly223Arg Uncertain significance Single submitter
- DIPK1B p.Gly233Asp Uncertain significance Single submitter
- DIPK1B p.Gly233Ser Uncertain significance Single submitter
- DIPK1B p.Gly237Asp Uncertain significance Single submitter
- DIPK1B p.Gly288Ser Uncertain significance Single submitter
- DIPK1B p.Gly291Arg Uncertain significance Single submitter
- DIPK1B p.Gly375Ser Uncertain significance Single submitter
- DIPK1B p.Gly401Arg Uncertain significance Single submitter
- DIPK1B p.Gly42Val Uncertain significance Single submitter
- DIPK1B p.Gly59Ser Uncertain significance Single submitter
- DIPK1B p.His236Arg Uncertain significance Single submitter
- DIPK1B p.His9Arg Uncertain significance Single submitter
- DIPK1B p.Ile32Met Uncertain significance Single submitter
- DIPK1B p.Leu24Phe Uncertain significance Single submitter
- DIPK1B p.Leu366Arg Uncertain significance Single submitter
- DIPK1B p.Leu37Arg Uncertain significance Single submitter
- DIPK1B p.Lys126Asn Uncertain significance Single submitter
- DIPK1B p.Lys142Arg Uncertain significance Single submitter
- DIPK1B p.Lys150Arg Uncertain significance Single submitter
- DIPK1B p.Lys150Thr Uncertain significance Single submitter
- DIPK1B p.Lys215Glu Uncertain significance Single submitter
- DIPK1B p.Met295Ile Uncertain significance Single submitter
- DIPK1B p.Met295Val Uncertain significance Single submitter
- DIPK1B p.Met88Ile Uncertain significance Single submitter
- DIPK1B p.Pro235Leu Uncertain significance Single submitter
- DIPK1B p.Pro250Ser Uncertain significance Single submitter
- DIPK1B p.Pro99Leu Uncertain significance Single submitter
- DIPK1B p.Ser129Leu Uncertain significance Single submitter
- DIPK1B p.Ser415Asn Uncertain significance Single submitter
- DIPK1B p.Ser51Leu Uncertain significance Single submitter
- DIPK1B p.Ser54Leu Uncertain significance Single submitter
- DIPK1B p.Ser96Pro Uncertain significance Single submitter
- DIPK1B p.Thr308Ala Uncertain significance Single submitter
- DIPK1B p.Tyr229Cys Uncertain significance Single submitter
- DIPK1B p.Val197Met Uncertain significance Single submitter
- DIPK1B p.Val234Met Uncertain significance Single submitter
- DIPK1B p.Val48Met Uncertain significance Single submitter
- DIPK1B p.Val89Leu Uncertain significance Single submitter
- DIPK1B p.Val97Leu Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- DIPK1B p.Ala172Val Uncertain significance Single submitter
- DIPK1B p.Ala241Val Likely benign Single submitter
- DIPK1B p.Ala272Thr Uncertain significance Single submitter
- DIPK1B p.Ala275Val Uncertain significance Single submitter
- DIPK1B p.Ala371Pro Uncertain significance Single submitter
- DIPK1B p.Ala383Thr Uncertain significance Single submitter
- DIPK1B p.Arg128Trp Uncertain significance Single submitter
- DIPK1B p.Arg135Trp Uncertain significance Single submitter
- DIPK1B p.Arg153Trp Uncertain significance Single submitter
- DIPK1B p.Arg188Trp Uncertain significance Single submitter
- DIPK1B p.Arg203Cys Uncertain significance Single submitter
- DIPK1B p.Arg23Gln Uncertain significance Single submitter
- DIPK1B p.Arg249Cys Uncertain significance Single submitter
- DIPK1B p.Arg271Gln Uncertain significance Single submitter
- DIPK1B p.Arg327His Uncertain significance Single submitter
- DIPK1B p.Arg332Cys Uncertain significance Single submitter
- DIPK1B p.Arg332His Uncertain significance Single submitter
- DIPK1B p.Arg386Cys Uncertain significance Single submitter
- DIPK1B p.Arg386His Uncertain significance Single submitter
- DIPK1B p.Arg394Cys Uncertain significance Single submitter
- DIPK1B p.Arg56Cys Uncertain significance Single submitter
- DIPK1B p.Asn204Lys Uncertain significance Single submitter
- DIPK1B p.Asp315Asn Uncertain significance Single submitter
- DIPK1B p.Asp339Asn Uncertain significance Single submitter
- DIPK1B p.Asp339Glu Uncertain significance Single submitter
- DIPK1B p.Glu232Lys Uncertain significance Single submitter
- DIPK1B p.Glu322Ala Uncertain significance Single submitter
- DIPK1B p.Glu387Lys Uncertain significance Single submitter
- DIPK1B p.Gly359Ser Uncertain significance Single submitter
- DIPK1B p.Gly380Asp Uncertain significance Single submitter
- DIPK1B p.Leu167Met Uncertain significance Single submitter
- DIPK1B p.Lys185Glu Uncertain significance Single submitter
- DIPK1B p.Lys424Met Uncertain significance Single submitter
- DIPK1B p.Met295Thr Uncertain significance Single submitter
- DIPK1B p.Pro15Arg Uncertain significance Single submitter
- DIPK1B p.Pro171Leu Uncertain significance Single submitter
- DIPK1B p.Ser169Phe Uncertain significance Single submitter
- DIPK1B p.Thr398Met Uncertain significance Single submitter
- DIPK1B p.Val303Met Uncertain significance Single submitter
- DIPK1B p.Val325Met Uncertain significance Single submitter
All DIPK1B variants
Likely benign 4
- p.Ala241Val Single submitter ⚠
- p.Arg333His Single submitter
- p.Val79Ile Single submitter
- p.Val97Ala Single submitter
Uncertain significance 110
- p.Ala132Thr Single submitter ⚠
- p.Ala172Val Single submitter ⚠
- p.Ala218Thr Single submitter ⚠
- p.Ala218Val Single submitter ⚠
- p.Ala259Thr Single submitter ⚠
- p.Ala272Thr Single submitter ⚠
- p.Ala275Val Single submitter ⚠
- p.Ala371Pro Single submitter ⚠
- p.Ala371Thr Single submitter ⚠
- p.Ala383Thr Single submitter ⚠
- p.Arg128Gln Single submitter ⚠
- p.Arg128Trp Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg135Trp Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg153Gln Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg188Gln Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg249His Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg30Cys Single submitter ⚠
- p.Arg30His Single submitter ⚠
- p.Arg327His Single submitter ⚠
- p.Arg332Cys Single submitter ⚠
- p.Arg332His Single submitter ⚠
- p.Arg333Gly Single submitter ⚠
- p.Arg344His Single submitter ⚠
- p.Arg374Gln Single submitter ⚠
- p.Arg374Trp Single submitter ⚠
- p.Arg386Cys Single submitter ⚠
- p.Arg386His Single submitter ⚠
- p.Arg394Cys Single submitter ⚠
- p.Arg56Cys Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Arg92Lys Single submitter ⚠
- p.Asn204Asp Single submitter ⚠
- p.Asn204Lys Single submitter ⚠
- p.Asp124Asn Single submitter ⚠
- p.Asp315Asn Single submitter ⚠
- p.Asp339Asn Single submitter ⚠
- p.Asp339Glu Single submitter ⚠
- p.Cys357Ser Single submitter ⚠
- p.Gln21Pro Single submitter ⚠
- p.Gln363His Single submitter ⚠
- p.Gln405His Single submitter ⚠
- p.Glu120Gly Single submitter ⚠
- p.Glu214Gly Single submitter ⚠
- p.Glu232Lys Single submitter ⚠
- p.Glu283Gln Single submitter ⚠
- p.Glu322Ala Single submitter ⚠
- p.Glu335Lys Single submitter ⚠
- p.Glu387Lys Single submitter ⚠
- p.Glu407Gly Single submitter ⚠
- p.Glu55Lys Single submitter ⚠
- p.Gly223Arg Single submitter ⚠
- p.Gly233Asp Single submitter ⚠
- p.Gly233Ser Single submitter ⚠
- p.Gly237Asp Single submitter ⚠
- p.Gly288Ser Single submitter ⚠
- p.Gly291Arg Single submitter ⚠
- p.Gly359Ser Single submitter ⚠
- p.Gly375Ser Single submitter ⚠
- p.Gly380Asp Single submitter ⚠
- p.Gly401Arg Single submitter ⚠
- p.Gly42Val Single submitter ⚠
- p.Gly59Ser Single submitter ⚠
- p.His236Arg Single submitter ⚠
- p.His9Arg Single submitter ⚠
- p.Ile32Met Single submitter ⚠
- p.Leu167Met Single submitter ⚠
- p.Leu24Phe Single submitter ⚠
- p.Leu366Arg Single submitter ⚠
- p.Leu37Arg Single submitter ⚠
- p.Lys126Asn Single submitter ⚠
- p.Lys142Arg Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Lys150Thr Single submitter ⚠
- p.Lys185Glu Single submitter ⚠
- p.Lys215Glu Single submitter ⚠
- p.Lys424Met Single submitter ⚠
- p.Met295Ile Single submitter ⚠
- p.Met295Thr Single submitter ⚠
- p.Met295Val Single submitter ⚠
- p.Met88Ile Single submitter ⚠
- p.Pro15Arg Single submitter ⚠
- p.Pro171Leu Single submitter ⚠
- p.Pro235Leu Single submitter ⚠
- p.Pro250Ser Single submitter ⚠
- p.Pro99Leu Single submitter ⚠
- p.Ser129Leu Single submitter ⚠
- p.Ser169Phe Single submitter ⚠
- p.Ser415Asn Single submitter ⚠
- p.Ser51Leu Single submitter ⚠
- p.Ser54Leu Single submitter ⚠
- p.Ser96Pro Single submitter ⚠
- p.Thr308Ala Single submitter ⚠
- p.Thr398Met Single submitter ⚠
- p.Tyr229Cys Single submitter ⚠
- p.Val197Met Single submitter ⚠
- p.Val234Met Single submitter ⚠
- p.Val303Met Single submitter ⚠
- p.Val325Met Single submitter ⚠
- p.Val48Met Single submitter ⚠
- p.Val89Leu Single submitter ⚠
- p.Val97Leu Single submitter ⚠