DIRAS2 — 11 ClinVar variants
All ClinVar germline DIRAS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
2 Benign · 9 Uncertain significance
Full DIRAS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DIRAS2 p.Ala146Thr Uncertain significance Single submitter
- DIRAS2 p.Gln177Arg Uncertain significance Single submitter
- DIRAS2 p.Glu190Asp Uncertain significance Single submitter
- DIRAS2 p.Ile88Val Uncertain significance Single submitter
- DIRAS2 p.Pro127Leu Uncertain significance Single submitter
- DIRAS2 p.Ser53Asn Uncertain significance Single submitter
- DIRAS2 p.Ser5Arg Uncertain significance Single submitter
- DIRAS2 p.Thr62Arg Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All DIRAS2 variants
Uncertain significance 9
- p.Ala146Thr Single submitter ⚠
- p.Arg73Gln Single submitter ⚠
- p.Gln177Arg Single submitter ⚠
- p.Glu190Asp Single submitter ⚠
- p.Ile88Val Single submitter ⚠
- p.Pro127Leu Single submitter ⚠
- p.Ser53Asn Single submitter ⚠
- p.Ser5Arg Single submitter ⚠
- p.Thr62Arg Single submitter ⚠