DISP2 — 245 ClinVar variants

All ClinVar germline DISP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 236 flagged for review →

1 Conflicting · 1 Benign · 9 Likely benign · 234 Uncertain significance

Full DISP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 236

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 132

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 104

The independent predictors disagree with each other — read with care.

All DISP2 variants

Conflicting classifications of pathogenicity 1

Benign 1

Likely benign 9

Uncertain significance 234