DKK1 — 44 ClinVar variants
All ClinVar germline DKK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Conflicting · 2 Benign · 1 Benign/Likely benign · 8 Likely benign · 32 Uncertain significance
Full DKK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DKK1 p.Arg115Lys Uncertain significance Single submitter
- DKK1 p.Asn38Thr Uncertain significance Single submitter
- DKK1 p.Asp142Asn Uncertain significance Single submitter
- DKK1 p.Glu151Val Uncertain significance Single submitter
- DKK1 p.Gly186Cys Uncertain significance Single submitter
- DKK1 p.Gly5Arg Uncertain significance Single submitter
- DKK1 p.Gly65Arg Uncertain significance Single submitter
- DKK1 p.His252Arg Uncertain significance Single submitter
- DKK1 p.Ile137Met Uncertain significance Single submitter
- DKK1 p.Ile77Thr Uncertain significance Single submitter
- DKK1 p.Met178Leu Uncertain significance Single submitter
- DKK1 p.Pro212Ser Uncertain significance Single submitter
- DKK1 p.Pro212Thr Uncertain significance Single submitter
- DKK1 p.Pro46His Uncertain significance Single submitter
- DKK1 p.Pro82Leu Uncertain significance Single submitter
- DKK1 p.Thr172Asn Uncertain significance Single submitter
- DKK1 p.Tyr74Asn Uncertain significance Single submitter
- DKK1 p.Tyr83His Uncertain significance Single submitter
- DKK1 p.Val36Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- DKK1 p.Ala196Val Uncertain significance Single submitter
- DKK1 p.Ala19Thr Uncertain significance Single submitter
- DKK1 p.Ala98Pro Uncertain significance Single submitter
- DKK1 p.Arg11Gln Uncertain significance Single submitter
- DKK1 p.Arg246Trp Uncertain significance Single submitter
- DKK1 p.Gly54Glu Uncertain significance Single submitter
- DKK1 p.His124Gln Uncertain significance Single submitter
- DKK1 p.His229Asn Uncertain significance Single submitter
- DKK1 p.His229Tyr Uncertain significance Single submitter
- DKK1 p.Phe146Cys Uncertain significance Single submitter
- DKK1 p.Ser257Pro Uncertain significance Single submitter
- DKK1 p.Ser61Arg Uncertain significance Single submitter
- DKK1 p.Thr262Ala Uncertain significance Single submitter
All DKK1 variants
Conflicting classifications of pathogenicity 1
- p.Ala113Thr Single submitter ⚠
Benign 2
- c.244-6C>T Multiple submitters
- p.Met16Leu Single submitter
Benign/Likely benign 1
- c.548-4G>A Multiple submitters
Likely benign 8
- p.Ala106Thr Single submitter
- p.Ala15= Single submitter
- p.Arg224= Single submitter
- p.Asp94Glu Single submitter
- p.His229= Single submitter
- p.Leu37= Single submitter
- c.243+9G>A No assertion criteria DKK1-related disorder
- p.Arg120Leu No assertion criteria DKK1-related disorder
Uncertain significance 32
- p.Ala196Val Single submitter ⚠
- p.Ala19Thr Single submitter ⚠
- p.Ala98Pro Single submitter ⚠
- p.Arg115Lys Single submitter ⚠
- p.Arg11Gln Single submitter ⚠
- p.Arg246Trp Single submitter ⚠
- p.Asn38Thr Single submitter ⚠
- p.Asp142Asn Single submitter ⚠
- p.Glu151Val Single submitter ⚠
- p.Gly186Cys Single submitter ⚠
- p.Gly54Glu Single submitter ⚠
- p.Gly5Arg Single submitter ⚠
- p.Gly65Arg Single submitter ⚠
- p.His124Gln Single submitter ⚠
- p.His229Asn Single submitter ⚠
- p.His229Tyr Single submitter ⚠
- p.His252Arg Single submitter ⚠
- p.Ile137Met Single submitter ⚠
- p.Ile77Thr Single submitter ⚠
- p.Met178Leu Single submitter ⚠
- p.Phe146Cys Single submitter ⚠
- p.Pro212Ser Single submitter ⚠
- p.Pro212Thr Single submitter ⚠
- p.Pro46His Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser257Pro Single submitter ⚠
- p.Ser61Arg Single submitter ⚠
- p.Thr172Asn Single submitter ⚠
- p.Thr262Ala Single submitter ⚠
- p.Tyr74Asn Single submitter ⚠
- p.Tyr83His Single submitter ⚠
- p.Val36Ile Single submitter ⚠