DKK2 — 27 ClinVar variants
All ClinVar germline DKK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
27 Uncertain significance
Full DKK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DKK2 p.Ala3Thr Uncertain significance Single submitter
- DKK2 p.Ala75Thr Uncertain significance Single submitter
- DKK2 p.Arg104Gln Uncertain significance Single submitter
- DKK2 p.Asp9Tyr Uncertain significance Single submitter
- DKK2 p.Cys189Ser Uncertain significance Single submitter
- DKK2 p.Gly153Ser Uncertain significance Single submitter
- DKK2 p.Gly192Val Uncertain significance Single submitter
- DKK2 p.Gly221Arg Uncertain significance Single submitter
- DKK2 p.Gly44Glu Uncertain significance Single submitter
- DKK2 p.His158Arg Uncertain significance Single submitter
- DKK2 p.Leu42Val Uncertain significance Single submitter
- DKK2 p.Met101Val Uncertain significance Single submitter
- DKK2 p.Met172Leu Uncertain significance Single submitter
- DKK2 p.Met22Ile Uncertain significance Single submitter
- DKK2 p.Pro77His Uncertain significance Single submitter
- DKK2 p.Ser25Thr Uncertain significance Single submitter
- DKK2 p.Trp242Arg Uncertain significance Single submitter
- DKK2 p.Tyr247Asn Uncertain significance Single submitter
- DKK2 p.Val86Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DKK2 p.Arg218Cys Uncertain significance Single submitter
- DKK2 p.Asn36Lys Uncertain significance Single submitter
- DKK2 p.Asp232Asn Uncertain significance Single submitter
- DKK2 p.Asp244Glu Uncertain significance Single submitter
- DKK2 p.Leu15Phe Uncertain significance Single submitter
- DKK2 p.Lys171Asn Uncertain significance Single submitter
- DKK2 p.Ser7Asn Uncertain significance Single submitter
- DKK2 p.Ser98Pro Uncertain significance Single submitter
All DKK2 variants
Uncertain significance 27
- p.Ala3Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg218Cys Single submitter ⚠
- p.Asn36Lys Single submitter ⚠
- p.Asp232Asn Single submitter ⚠
- p.Asp244Glu Single submitter ⚠
- p.Asp9Tyr Single submitter ⚠
- p.Cys189Ser Single submitter ⚠
- p.Gly153Ser Single submitter ⚠
- p.Gly192Val Single submitter ⚠
- p.Gly221Arg Single submitter ⚠
- p.Gly44Glu Single submitter ⚠
- p.His158Arg Single submitter ⚠
- p.Leu15Phe Single submitter ⚠
- p.Leu42Val Single submitter ⚠
- p.Lys171Asn Single submitter ⚠
- p.Met101Val Single submitter ⚠
- p.Met172Leu Single submitter ⚠
- p.Met22Ile Single submitter ⚠
- p.Pro77His Single submitter ⚠
- p.Ser25Thr Single submitter ⚠
- p.Ser7Asn Single submitter ⚠
- p.Ser98Pro Single submitter ⚠
- p.Trp242Arg Single submitter ⚠
- p.Tyr247Asn Single submitter ⚠
- p.Val86Ile Single submitter ⚠