DKK4 — 43 ClinVar variants
All ClinVar germline DKK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
5 Likely benign · 38 Uncertain significance
Full DKK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- DKK4 p.Ala30Thr Uncertain significance Single submitter
- DKK4 p.Arg102Ser Uncertain significance Single submitter
- DKK4 p.Arg159Ser Uncertain significance Single submitter
- DKK4 p.Arg210Trp Uncertain significance Single submitter
- DKK4 p.Arg36Trp Uncertain significance Single submitter
- DKK4 p.Arg75Gln Uncertain significance Single submitter
- DKK4 p.Asn123Lys Uncertain significance Single submitter
- DKK4 p.Asp150Tyr Uncertain significance Single submitter
- DKK4 p.Asp195Asn Uncertain significance Single submitter
- DKK4 p.Cys151Tyr Uncertain significance Single submitter
- DKK4 p.Cys196Phe Uncertain significance Single submitter
- DKK4 p.Cys202Tyr Uncertain significance Single submitter
- DKK4 p.Cys218Arg Uncertain significance Single submitter
- DKK4 p.Cys218Gly Uncertain significance Single submitter
- DKK4 p.Cys218Ser Uncertain significance Single submitter
- DKK4 p.Cys41Tyr Uncertain significance Single submitter
- DKK4 p.Cys47Ser Uncertain significance Single submitter
- DKK4 p.Cys66Arg Uncertain significance Single submitter
- DKK4 p.Gln40Arg Uncertain significance Single submitter
- DKK4 p.Gly68Glu Uncertain significance Single submitter
- DKK4 p.His111Gln Uncertain significance Single submitter
- DKK4 p.Ile99Val Uncertain significance Single submitter
- DKK4 p.Leu42Arg Uncertain significance Single submitter
- DKK4 p.Lys223Glu Uncertain significance Single submitter
- DKK4 p.Ser204Gly Uncertain significance Single submitter
- DKK4 p.Val5Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- DKK4 p.Arg179Ser Uncertain significance Single submitter
- DKK4 p.Arg57Cys Uncertain significance Single submitter
- DKK4 p.Gly8Arg Uncertain significance Single submitter
- DKK4 p.Phe191Leu Uncertain significance Single submitter
- DKK4 p.Phe191Ser Uncertain significance Single submitter
- DKK4 p.Pro61Leu Uncertain significance Single submitter
- DKK4 p.Ser177Pro Uncertain significance Single submitter
- DKK4 p.Thr163Met Uncertain significance Single submitter
All DKK4 variants
Likely benign 5
- p.Arg57His Single submitter
- p.Arg70Gln Single submitter
- p.Gly109Asp Single submitter
- p.Gly117Glu Single submitter
- p.Thr45Met Single submitter
Uncertain significance 38
- p.Ala30Thr Single submitter ⚠
- p.Arg102Ser Single submitter ⚠
- p.Arg159His Single submitter
- p.Arg159Ser Single submitter ⚠
- p.Arg179Ser Single submitter ⚠
- p.Arg210Trp Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Arg57Cys Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Asn123Lys Single submitter ⚠
- p.Asp150Tyr Single submitter ⚠
- p.Asp195Asn Single submitter ⚠
- p.Asp46Tyr Single submitter
- p.Cys151Tyr Single submitter ⚠
- p.Cys196Phe Single submitter ⚠
- p.Cys202Tyr Single submitter ⚠
- p.Cys218Arg Single submitter ⚠
- p.Cys218Gly Single submitter ⚠
- p.Cys218Ser Single submitter ⚠
- p.Cys41Tyr Single submitter ⚠
- p.Cys47Ser Single submitter ⚠
- p.Cys66Arg Single submitter ⚠
- p.Gln40Arg Single submitter ⚠
- p.Glu172Asp Single submitter
- p.Gly68Glu Single submitter ⚠
- p.Gly8Arg Single submitter ⚠
- p.His111Gln Single submitter ⚠
- p.Ile99Val Single submitter ⚠
- p.Leu19Pro Single submitter
- p.Leu42Arg Single submitter ⚠
- p.Lys223Glu Single submitter ⚠
- p.Phe191Leu Single submitter ⚠
- p.Phe191Ser Single submitter ⚠
- p.Pro61Leu Single submitter ⚠
- p.Ser177Pro Single submitter ⚠
- p.Ser204Gly Single submitter ⚠
- p.Thr163Met Single submitter ⚠
- p.Val5Ile Single submitter ⚠